Boswellic acids target the human immune system-modulating antimicrobial peptide LL-37

Henkel, Arne; Tausch, Lars; Pillong, Max; Jauch, Johann; Karas, Michael; Schneider, Gisbert; Werz, Oliver

doi:10.1016/j.phrs.2015.09.002

Cited by 15 publications

(7 citation statements)

References 33 publications

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“…Additional, comprehensive inquiries exhibited Boswellia acids as non-redox inhibitors, which might provide a site for pentacyclic triterpenes on 5-LOX (Roy et al, 2019). Henkel et al (2015) demonstrated that the anti-inflammatory mechanism of BAs was related to the inhibition of antimicrobial peptide LL-37. Thus, BAs could be used as a potential drug to interfere with LL-37 and related diseases.…”

Section: Pharmacological Properties Of Boswellia Acidsmentioning

confidence: 99%

Role of Boswellic Acid in the Treatment of Peptic Ulcer Disease

Sherif¹

2019

Al-Azhar Journal of Pharmaceutical Sciences

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A peptic ulcer is a chronic disease. Its main features are the incompetent defense of the mucosal and the existence of the gastric juice. The two most important factors that disrupt the balance between the acid and the mucus are the Helicobacter pylori infection (H. pylori) and Non-steroidal anti-inflammatory drugs (NSAIDs). The known treatments like proton pump inhibitors (PPIs) and histamine-2 (H2) receptor antagonists have demonstrated adverse effects and various drug interactions. So the desired approach nowadays is alternative therapies and the usage of herbal products. Boswellic acids provide a potential alternative to the treatment of non-steroidal anti-inflammatory drugs induced peptic ulcer.

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Section: Pharmacological Properties Of Boswellia Acidsmentioning

confidence: 99%

Role of Boswellic Acid in the Treatment of Peptic Ulcer Disease

Sherif¹

2019

Al-Azhar Journal of Pharmaceutical Sciences

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“…Therefore, for quality control, we finally settled on 13 components. Bet and Ace are came from Myrrha and Olibanum, whose ethanol extracts have anti-inflammatory activities for various acute and chronic inflammation [18,19]. The extraction of Olibanum has the function of inhibiting the generation of 5-hydroxy-24eicosatetraenoic acid and leukotriene and reducing the forming of 5-lipoxygenase (5-LOX) [18].…”

Section: Discussionmentioning

confidence: 99%

Identification of quality markers of Xiaojin Pills using a combination of high-performance liquid chromatographtandem mass spectrometry and multivariate analysis

Xiong¹,

He²,

Feng³

et al. 2018

Trop. J. Pharm Res

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Purpose: To establish an appropriate quality control method for Xiaojin pills using high-performance liquid chromatograph-tandem mass spectrometry combined with multivariate analysis. Methods: High-performance liquid chromatograph-tandem mass spectrometry was established to detect and quantify 13 chemical components of Xiaojin Pills. In order to evaluate the quality difference between diverse specimens of Xiaojin Pills, several multivariate statistical techniques were applied to analyze the dissimilarity between different batches of samples, including principal composition analysis method and clustering methodology. Results: Five chemical components were identified as primary quality markers, which can be used to accurately distinguish various samples and command the quality of Xiaojin Pills. Conclusion: The results afford a professionally scientific basis for the quality monitoring of Xiaojin Pills and also furnishes reasonable ideas and suggestions for the quality control of other traditional drugs.

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“…These substances differ in molecular size, spectrum of action; they are considered the major components of the innate immune system and work in defense against infections caused by viruses, bacteria and fungi [20][21][22][23][24][25][26][27][28][29][30][31][32][33] . Furthermore, recent studies indicate that the AMP may exercise activities such as immunological modulators [34,35] in the treatment of cancer [36] , in the recovery of skin lesions and as an alternative in the treatment of biofilms formed by pathogenic microorganisms [37] . The AMPs, in general, are substances that have fewer than 100 amino acids with a molecular weight below 5000 Daltons, although there have already been found peptides containing between 130 and 150 amino acids.…”

Section: General Characteristics Of the Ampsmentioning

confidence: 99%

Technological Potential of Antimicrobial Peptides: a Systematic Review

Machado¹,

Gelinski²,

Baratto³

et al. 2019

ijps

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Machado et al.: Review of Antimicrobial Peptides Resistance to antibiotics has being considered one of the greatest public health problems worldwide. The objective of this systematic review was to compile important bibliographical references that support the studies related to the biotechnological potential of antimicrobial peptides. Antimicrobial peptides are considered the major components of the innate immune system and work in defence against infections caused by different microorganisms. Many researchers argue that the studies associated with the discoveries of antimicrobial peptides that are more effective in the treatment of infections caused by microorganisms be also directed to the substances produced by insects. The major aspects associated to the technological potential of antimicrobial peptides are, general characteristics, classification, mode of action and prospects for applying, mainly in the pharmaceutical industry. It can be concluded that research for new substances with action against pathogenic microorganisms aim mainly to seek alternatives to the use of antibiotics. In addition, anticancer peptides are small cationic molecules with promising pharmacological use. However, the products for application in the protection of food, treatment of skin infections and its use in the cosmetics industry are those with the greatest potential.

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Boswellic acids target the human immune system-modulating antimicrobial peptide LL-37

Cited by 15 publications

References 33 publications

Role of Boswellic Acid in the Treatment of Peptic Ulcer Disease

Role of Boswellic Acid in the Treatment of Peptic Ulcer Disease

Identification of quality markers of Xiaojin Pills using a combination of high-performance liquid chromatographtandem mass spectrometry and multivariate analysis

Technological Potential of Antimicrobial Peptides: a Systematic Review

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