Both a reduced acute insulin response to glucose and lower glucose effectiveness are responsible for the worsening of intravenous glucose tolerance in healthy subjects independently of the degree of obesity

Araújo‐Vilar, David; García-Estévez, D A; Cabezas-Cerrato, J

doi:10.1016/s0026-0495(98)90263-3

Cited by 14 publications

(10 citation statements)

References 54 publications

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“…All samples were kept on ice until centrifugation. Later, the aliquots were centrifuged and stored at –20 °C pending determination of glucose and insulin 17,18 …”

Section: Methodsmentioning

confidence: 99%

“…Later, the aliquots were centrifuged and stored at -20 ° C pending determination of glucose and insulin. 17,18 Bergman's minimal model was used to calculate the insulin sensitivity index S I . 19,20 Briefly, the minimal model is a mathematical representation of glucose kinetics during a frequently sampled intravenous glucose tolerance (FSIGT) test, represented by two nonlinear, first-degree differential equations.…”

Section: Insulin Resistance Studymentioning

confidence: 99%

“…Fasting serum samples were analysed for glucose, cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, leptin and insulin, as described previously. 12,17 Blood haemoglobin A1c was measured using ion-exchange high-performance liquid chromatography (Bio-Rad Laboratories, Inc., Hercules, CA). TNF-α and IL-6 were measured by high-sensitivity enzyme-linked immunoassay (R&D Systems, Inc., Minneapolis, MN).…”

Section: Biochemical Analysesmentioning

confidence: 99%

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A novel phenotypic expression associated with a new mutation in LMNA gene, characterized by partial lipodystrophy, insulin resistance, aortic stenosis and hypertrophic cardiomyopathy

Araújo‐Vilar

Lado-Abeal

Palos-Paz

et al. 2008

Clinical Endocrinology

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“…All samples were kept on ice until centrifugation. Later, the aliquots were centrifuged and stored at –20 °C pending determination of glucose and insulin 17,18 …”

Section: Methodsmentioning

confidence: 99%

Section: Insulin Resistance Studymentioning

confidence: 99%

Section: Biochemical Analysesmentioning

confidence: 99%

See 1 more Smart Citation

A novel phenotypic expression associated with a new mutation in LMNA gene, characterized by partial lipodystrophy, insulin resistance, aortic stenosis and hypertrophic cardiomyopathy

Araújo‐Vilar

Lado-Abeal

Palos-Paz

et al. 2008

Clinical Endocrinology

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“…K g , used as a measure of overall intravenous glucose tolerance, was an estimate of the disappearance rate (%/min) of plasma glucose based on the slope of the line derived from least‐squares regression of the natural logarithm of plasma glucose on time from 10 through 60 min during the IVGTT [35]. AIR Glucose was computed as the incremental integrated area under the insulin curve for the first 10 min of the IVGTT and used as an index of insulin secretion.…”

Section: Methodsmentioning

confidence: 99%

Familial resemblance for glucose and insulin metabolism indices derived from an intravenous glucose tolerance test in Blacks and Whites of the HERITAGE Family Study

et al. 2001

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Type 2 diabetes mellitus (T2DM), characterized by hyperglycemia, is a complex disease primarily caused by impairment in insulin sensitivity (SI) and insulin secretion. While a strong genetic component for T2DM is well established, there are few reports on racial differences in the magnitude of the genetic effects of T2DM and indices of glucose and insulin metabolism. We report here on the familial resemblance for traits related to glucose metabolism at pre-exercise training levels in 492 members from 99 sedentary White families and 259 members from 108 Black families participating in the multicenter HERITAGE Family Study. All these traits were obtained from the frequently sampled intravenous glucose tolerance test (IVGTT). They include glucose disappearance index (Kg), an overall index for glucose tolerance, acute insulin response to glucose (AIR(Glucose)) which is an index for insulin secretion, and those derived from the minimal model including SI and the disposition index (DI). DI, derived as the product of SI and AIR(Glucose), is a measure of the activity of the B-cells adjusted for insulin resistance. After adjustment for age, sex, and body mass index, the maximal heritability estimates in Blacks (Whites) are 48+/-14% (25+/-8%) for Kg, 44+/-14% (46+/-8%) for AIR(Glucose), 38+/-12% (44+/-8%) for SI and 32+/-14% (24+/-8%) for DI. Interestingly, Blacks have higher heritability for overall glucose tolerance than Whites but there is no race difference in heritability estimates for insulin sensitivity or insulin secretion.

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“…K g is an estimate of the disappearance rate (percent/minute) of plasma glucose based on the slope of plasma glucose from 10 through 60 min during the IVGTT (27). The insulin sensitivity index (S i ) and glucose effectiveness (S g ) were derived from MINMOD analysis (MINMOD Millennium, version 5.18).…”

Section: Ivgtt-derived Variablesmentioning

confidence: 99%

Effects of Exercise Training on Glucose Homeostasis

et al. 2005

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OBJECTIVE -To determine the effect of a 20-week endurance training program in healthy, previously sedentary participants on measures derived from an intravenous glucose tolerance test (IVGTT).RESEARCH DESIGN AND METHODS -An IVGTT was performed before and after a standardized training program in 316 women and 280 men (173 blacks and 423 whites). Participants exercised on cycle ergometers 3 days per week for 60 sessions. The exercise intensity was progressively increased from 55% VO 2max for 30 min per session to 75% VO 2max for 50 min per session.RESULTS -Mean insulin sensitivity increased by 10% (P Ͻ 0.001) following the intervention, but the variability in the changes was high. Men had larger improvements than women (P ϭ 0.02). Improvements in fasting insulin were transitory, disappearing 72 h after the last bout of exercise. There were also significant mean increases in the glucose disappearance index (3%, P ϭ 0.02) and in glucose effectiveness (11%, P Ͻ 0.001), measures of glucose tolerance and of the capacity of glucose to mediate its own disposal, respectively. The acute insulin response to glucose, a measure of insulin secretion, increased by 7% in the quartile with the lowest baseline glucose tolerance and decreased by 14% in the quartile with the highest baseline glucose tolerance (P Ͻ 0.001). The glucose area below fasting levels during the IVGTT was reduced by 7% (P ϭ 0.02).CONCLUSIONS -Although the effects of structured regular exercise were highly variable, there were improvements in virtually all IVGTT-derived variables. In the absence of substantial weight loss, regular exercise is required for sustained improvements in glucose homeostasis. Diabetes Care 28:120 -126, 2005

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Both a reduced acute insulin response to glucose and lower glucose effectiveness are responsible for the worsening of intravenous glucose tolerance in healthy subjects independently of the degree of obesity

Cited by 14 publications

References 54 publications

A novel phenotypic expression associated with a new mutation in LMNA gene, characterized by partial lipodystrophy, insulin resistance, aortic stenosis and hypertrophic cardiomyopathy

A novel phenotypic expression associated with a new mutation in LMNA gene, characterized by partial lipodystrophy, insulin resistance, aortic stenosis and hypertrophic cardiomyopathy

Familial resemblance for glucose and insulin metabolism indices derived from an intravenous glucose tolerance test in Blacks and Whites of the HERITAGE Family Study

Effects of Exercise Training on Glucose Homeostasis

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