2003
DOI: 10.1097/00001756-200308060-00013
|View full text |Cite
|
Sign up to set email alerts
|

Both aging and chronic fluoxetine increase S100B content in the mouse hippocampus

Abstract: S100B is a cytokine with neurotrophic and neurite-extending activity that has been implicated in the mechanism of action of anti-depressants and in the pathobiology of aging associated disorders such as Alzheimer's disease. The antidepressant fluoxetine increases hippocampal S100B content in young adult rats. In humans, brain levels of S100B mRNA and protein increase with advancing age. We assayed hippocampal S100B protein content in young (2 month) and old (24 month) mice, and in old mice treated for 2 weeks … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

4
27
2
3

Year Published

2004
2004
2021
2021

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 39 publications
(36 citation statements)
references
References 22 publications
4
27
2
3
Order By: Relevance
“…Its expression level has been reported to increase with aging (26) and to correlate positively with AD (27). However, our RT-PCR analysis did not confirm either the correlation with AD or the microarray result (Fig.…”
Section: Reproducibility Of Changes In Gene Expression In Ad Braincontrasting
confidence: 76%
“…Its expression level has been reported to increase with aging (26) and to correlate positively with AD (27). However, our RT-PCR analysis did not confirm either the correlation with AD or the microarray result (Fig.…”
Section: Reproducibility Of Changes In Gene Expression In Ad Braincontrasting
confidence: 76%
“…4; also see Tubaro et al 2010), the question as to what mechanism is responsible for the higher S100B levels in aged SCs compared with young SCs still remains unresolved. Incidentally, enhanced expression levels of S100B are also found in the aging brain (Akhisaroglu et al 2003;Katoh-Semba and Kato 1994) again with no data about the mechanism underlying this event. The s100b promoter contains recognition sites for NF-κB raising the possibility that the relatively high NF-κB activity in aged SCs might result in upregulation of S100B which, in turn, would activate NF-κB in a feed-forward loop.…”
Section: Discussionmentioning
confidence: 99%
“…(Domesick, 1969). Nessa região que representa a porção medial do córtex pré frontal (Zilles et al, 1995), a proteína S100β imunoexpressou em elementos gliais com formato oval sem ramificações semelhantes aos que estudos demonstraram grande quantidade de S100β em astrócitos dessa região (Dong et al, 2006;Kato et al, 1990;Akhisaroglu et al, 2003).…”
Section: Córtexunclassified
“…A literatura descreve também estudos imuno-histoquímicos feitos na região do córtex frontal e temporal de humanos com a doença de alzheimer e sindrome de down por exemplo, fazendo referência também a presença de S100β nos astrócitos, mas agora associado a grandes quantidades da proteína (Wunderlich et al, 1999;Deloulme et al, 2004;Boyer et al, 1991;Akhisaroglu et al, 2003). Podemos sugerir que a S100β na região do córtex dos animais analisados no presente estudo seja expressa nessas células gliais específicas, devido à semelhança morfológica das células ovais e sem ramificações encontradas (Nishiyama et al, 2002).…”
Section: Córtexunclassified
See 1 more Smart Citation