Bottlebrush inspired injectable hydrogel for rapid prevention of postoperative and recurrent adhesion

Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials: Based on the mechanisms of occurrence and development of adhesions

“…Introducing ultra-hydrophilic structure could also improve the antifouling capability of hydrophilic polymers, further promoting adhesion prevention ability. Guo et al [ 222 ] introduced ultra-hydrophilic N-(2-hydroxypropyl) methacrylamide (HPMA) chains to the H-HPMA hydrogel through free-radical polymerization in an aqueous solution between the HPMA and methacrylate hyaluronic acid (HA-GMA) monomer. The introduction of the ultra-hydrophilic HPMA chains afforded a satisfying antifouling capability because of the established dense hydrated layer, furthermore, rapidly prevented the postsurgical adhesions and recurrent adhesions after adhesiolysis in vivo ( Fig.…”

Multifunctional Microgel-Based Cream Hydrogels for Postoperative Abdominal Adhesion Prevention

“…By combining the advantages of film and liquid barriers, the injectable hydrogel can perfectly cover irregular wounds and has shown potential in abdominal adhesion inhibition after open or laparoscopic surgery . Many types of injectable hydrogels with excellent antifouling adhesive capabilities, such as carboxyl-containing dynamically cross-linked supramolecular polymer–nanoparticle hydrogels, Janus hydrogels, , photocurable catechol-grafted hyaluronic acid (HA) hydrogels, , hotmelt tissue adhesives, bottlebrush inspired injectable hydrogels, cellulose-based thermo-gels, and zwitterionic hydrogels, , were prepared by using natural or synthetic polymers through chemical modification or cross-linking. Although efficacy has been shown, these hydrogel systems may encounter at least some of the following limitations: (1) rapid degradation rate and short retention time; (2) presence of toxic residues of cross-linking agents; (3) the use of ultraviolet irradiation; (4) lack of self-healing or self-fused ability to prevent fragmentation during the injection process; (5) slow hydrogel gelation.…”

A self-fused hydrogel for the treatment of glottic insufficiency through outstanding durability, extracellular matrix-inducing bioactivity and function preservation

“…Considering the unique mechanical properties of the VFs, the self-fusion properties of the hydrogels including self-healing and injectability were investigated [ 34 , 35 ]. Firstly, as illustrated in Fig.…”