Botulinum toxin type A for the first‐line treatment of Hailey–Hailey disease

Kothapalli, Anita; Caccetta, Tony

doi:10.1111/ajd.12852

Cited by 12 publications

(16 citation statements)

References 4 publications

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“…This effect and the subsequent decrease of microorganism colonization might serve as one explanation for its efficacy in the treatment of Hailey–Hailey disease (Benohanian, ). Botulinum toxin cannot cross the stratum corneum, therefore, its injection is required for both the treatment of hyperhidrosis (de Almeida & Montagner, ; Glaser & Galperin, ) and for the treatment of Hailey–Hailey disease (Charlton et al, ; Friedman et al, ; Kothapalli & Caccetta, ; Lapiere et al, ). It is an effective treatment but a painful, expensive, and the duration effects is for several months only.…”

Section: Discussionmentioning

confidence: 99%

“…Treatment with botulinum toxin was first described in 2000 (Lapiere, Hirsh, Gordon, Cook, & Montalvo, ) with promising, several months lasting, results (Charlton, Stewart, & Rosen, ; Friedman, Koren, Niv, Mehrabi, & Artzi, ; Kothapalli & Caccetta, ). The main disadvantages of this treatment are the high cost of the toxin and the excruciating pain as well as the risk of infections due to the numerous needle punctures.…”

Section: Introductionmentioning

confidence: 99%

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An enhanced transcutaneous delivery of botulinum toxin for the treatment of Hailey–Hailey disease

Bar‐Ilan

Koren

Shehadeh

et al. 2019

Dermatologic Therapy

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Successful treatment of Hailey-Hailey disease with intradermal botulinum toxininjections has been previously reported. The main disadvantages of this treatment are the excruciating pain and the risk of infections due to the numerous injections.We sought to evaluate the clinical effectiveness and safety profile of a novel approach using an energy-based device (Tixel, Novoxel, and Israel), followed by the topical application of botulinum toxin Type A for the treatment of Hailey-Hailey disease. A retrospective study of all cases of histologically diagnosed cases of Hailey-Hailey disease treated with Tixel device followed by topical application of botulinum toxin between 2018 and 2019 was performed. Epidemiologic, clinical, and treatment data, including effectiveness score and safety, were reviewed. The study included eight patients, of whom seven patients (87.5%) showed good or partial response. No systemic or local adverse effects were reported. There was no difference in effectivity between different body areas. Response to treatment ranged between patients with an average duration of 7.125 months after the second treatment. Tixel treatment followed by topical application of botulinum toxin can be considered in the treatment of Hailey-Hailey disease. This approach is less invasive, less painful, and yet effective as well as safe.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An enhanced transcutaneous delivery of botulinum toxin for the treatment of Hailey–Hailey disease

Bar‐Ilan

Koren

Shehadeh

et al. 2019

Dermatologic Therapy

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“…100 U BoNT-A was administrated in his axillae and groin (50 U at each site) once a year for two consecutive years with a consequent reduction of symptoms to two episodes a year. Recently, Kothapalli [137] suggested botulinum toxin injection be considered as a lifechanging first-line treatment for Hailey-Hailey. Table 8 collects all the studies on the use of BoNT-A therapy in HHD.…”

Section: Hailey-hailey Diseasementioning

confidence: 99%

Therapeutic Use of Botulinum Neurotoxins in Dermatology: Systematic Review

Martina

Diotallevi

Radi

et al. 2021

Toxins

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Botulinum toxin is a superfamily of neurotoxins produced by the bacterium Clostridium Botulinum with well-established efficacy and safety profile in focal idiopathic hyperhidrosis. Recently, botulinum toxins have also been used in many other skin diseases, in off label regimen. The objective of this manuscript is to review and analyze the main therapeutic applications of botulinum toxins in skin diseases. A systematic review of the published data was conducted, following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Botulinum toxins present several label and off-label indications of interest for dermatologists. The best-reported evidence concerns focal idiopathic hyperhidrosis, Raynaud phenomenon, suppurative hidradenitis, Hailey–Hailey disease, epidermolysis bullosa simplex Weber–Cockayne type, Darier’s disease, pachyonychia congenita, aquagenic keratoderma, alopecia, psoriasis, notalgia paresthetica, facial erythema and flushing, and oily skin. Further clinical trials are still needed to better understand the real efficacy and safety of these applications and to standardize injection and doses protocols for off label applications.

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“…Sixteen articles described the use of botulinum toxin in treating patients with Hailey-Hailey disease, and the detailed description was shown in Table 1. 14,16,17,21,[23][24][25][26][27][28][29][30][31][32][33][34] The articles were published between 2000 and 2020. A total of 38 patients were included.…”

Section: Re Sultsmentioning

confidence: 99%

“…This treatment has also been applied and improved in recent years. 16,17 There were also some articles in which patients failed botulinum toxin treatment, but were successfully treated by other treatment options. [18][19][20] This study aimed to examine all published articles on botulinum toxin in the treatment of Hailey-Hailey disease, and to evaluate its efficacy and safety.…”

mentioning

confidence: 99%

Botulinum toxin in treating Hailey‐Hailey disease: A systematic review

Zhang

Tang

Wang

et al. 2021

J of Cosmetic Dermatology

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Hailey-Hailey disease, also called benign familial chronic pemphigus, is a rare autosomal dominant disorder characterized by recurrent painful blistering, erosions, maceration in the intertriginous regions. 1,2 Hailey-Hailey disease is caused by mutations in the ATP2C1 gene located on chromosome 3q21-q24, whose function is to transport Ca 2+ /Mn 2+ into the Golgi apparatus and maintain normal intracellular concentrations of Ca 2+ /Mn 2+3 . The appearance of "dilapidated brick wall" was a characteristic histopathologic change of Hailey-Hailey disease. 4 Severe impairment of quality of life was observed in Hailey-Hailey disease in the aspects of symptoms, emotions, and social functioning. 5 Nowadays, treatment options for Hailey-Hailey disease include corticosteroids, antibiotics, botulinum toxin, CO 2 ablation laser, and dermabrasion. 6 CO 2 laser therapy as a long-term treatment option for Hailey-Hailey disease has been systematically reviewed, offering an effective and safe treatment option with minimal side effects. 7 Botulinum toxin has also been widely used in cosmetic dermatology, noncosmetic dermatology, and nondermatological indications. [8][9][10][11][12][13] As early as 2000, it was applied in a patient with Hailey-Hailey disease and provided a sustained

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Botulinum toxin type A for the first‐line treatment of Hailey–Hailey disease

Cited by 12 publications

References 4 publications

An enhanced transcutaneous delivery of botulinum toxin for the treatment of Hailey–Hailey disease

An enhanced transcutaneous delivery of botulinum toxin for the treatment of Hailey–Hailey disease

Therapeutic Use of Botulinum Neurotoxins in Dermatology: Systematic Review

Botulinum toxin in treating Hailey‐Hailey disease: A systematic review

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