Botulinum toxin type A intravesical injections for intractable bladder overactivity

Botulinum A toxin injections into the detrusor: An effective treatment in idiopathic and neurogenic detrusor overactivity?

“…Further studies are needed to determine if lower BTX-A doses will have the same bene¢cial e¡ects, while avoiding the need for intermittent selfcatheterization or other forms of urinary drainage. In the present study, the duration of the BTX-A e¡ect in idiopathic as well as in neurogenic detrusor overactivity was similar to that observed by Kuo [2004] but less than reported in other studies [Schurch et al, 2000a,b;Radziszewski and Borkowski, 2002;Schulte-Baukloh et al, 2002Chancellor et al, 2003;Loch et al, 2003;Riccabona et al, 2004;Schmid et al, 2004]. Although di¡erences in baseline characteristicsöespecially in the neurogenic group considering that our study included only two patients with spinal cord injury and none with myelomeningoceleömay be assumed, the exact reason for this phenomenon remains unclear.…”

Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence

“…The use of botulinum toxin has increased rapidly, and successful treatment of neurogenic detrusor overactivity by intravesical botulinum toxin injections has now been reported by several groups . However, toxin injections may also be effective in refractory idiopathic detrusor overactivity (Radziszewski and Borkowski, 2002;Chancellor et al, 2003;Leippold et al, 2003;Rapp et al, 2004).…”

Botulinum toxin and perineal disorders

“…La première étude a été faite par Borkowski [19], avec de bons résultats illustrés par une augmentation de la capacité vésicale, une restauration de la continence et l'absence d'effets secondaires rapportés. Les études suivantes [20,21] ont confirmé l'efficacité de cette technique dans cette indication, avec des doses moindres que dans les vessies neurogènes (200 UI Botox ® en quarante sites) et avec environ 60 % d'amélioration (mais 20 % de rétention transitoire) évaluée sur des échelles de symptômes et de qualité de vie (UDI/IIQ).…”