Bound polyphenol extracted from jujube pulp triggers mitochondria-mediated apoptosis and cell cycle arrest of HepG2 cell in vitro and in vivo

Shan, Shuhua; Xie, Yue; Zhao, Haizhen; Niu, Jinping; Zhang, Sheng; Zhang, Xiaoli; Li, Zhuoyu

doi:10.1016/j.jff.2018.12.017

Cited by 12 publications

(6 citation statements)

References 37 publications

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“…Such effects are likely due to mitochondria-mediated intrinsic apoptosis and cell cycle arrest. 126 Overall, these findings together suggest that BPs may be potential therapeutic agents against cancer.…”

Section: Evidence Of the Health Benefits Of Bound Phenolicsmentioning

confidence: 93%

“…Besides, both in vitro and in vivo studies also demonstrated the antihepatoma effects of BPs (18.10 mg/g) and FBs (79.87 mg/g) from Chinese jujube pulp using HepG2 cells and the nude mice tumor model. Such effects are likely due to mitochondria-mediated intrinsic apoptosis and cell cycle arrest . Overall, these findings together suggest that BPs may be potential therapeutic agents against cancer.…”

Section: Evidence Of the Health Benefits Of Bound Phenolicsmentioning

confidence: 99%

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Review of Distribution, Extraction Methods, and Health Benefits of Bound Phenolics in Food Plants

Wang

Shi-yang

et al. 2020

J. Agric. Food Chem.

180

108

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Phenolic compounds are important functional bioactive substances distributed in various food plants. They have gained wide interest from researchers due to their multiple health benefits. There are two forms of phenolic compounds: free form and bound form. The latter is also called bound phenolics (BPs), which are found mainly in the cell wall and distributed in various tissues/organs of the plant body. They can either chemically bind to macromolecules and food matrixes or be physically entrapped in food matrixes and intact cells. Various isolation methods, including chemical, biological, and physical methods, have been employed to extract BPs from plants. BPs have been shown to have strong biological activities, including antioxidant, probiotic, anticancer, anti-inflammation, antiobesity, and antidiabetic effects as well as beneficial effects on central nervous system diseases. This review summarizes research findings on these topics to help in better understanding of BPs and provide comprehensive information on their health effects.

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Section: Evidence Of the Health Benefits Of Bound Phenolicsmentioning

confidence: 93%

Section: Evidence Of the Health Benefits Of Bound Phenolicsmentioning

confidence: 99%

Review of Distribution, Extraction Methods, and Health Benefits of Bound Phenolics in Food Plants

Wang

Shi-yang

et al. 2020

J. Agric. Food Chem.

180

108

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“…Nowadays the quest for new nanoparticles with specific biological, physical and chemical characteristics is still at the cutting edge of nanoscience research. Ziziphus species are commonly administered to treat many diseases viz., digestive complaints, causes of general weakness, hepatic disease, diabetes mellitus, as a dermatological whitening agent in skin care products and have antitumor activity for HepG2 cells (Salimi et al 2016, Shan et al 2019. In this research, synthesis and characterization of Z. spina-christi AgNPs through various stages of fruits maturation are recorded, which may be important for pharmaceuticals aspects.…”

Section: Resultsmentioning

confidence: 88%

Silver nanoparticles from Ziziphus spina-christi (L.) Desf. fruits extract and their antimicrobial activity

et al. 2020

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An easy and ecofriendly method to synthesize silver nanoparticles from different stages of ripening fruit extracts of Ziziphus spina-christi is demonstrated. UV-Vis spectroscopy showed a surface resonance peak at 423, 428 and 438 nm corresponding to the formation of AgNPs from ripened, unripened and young fruits, respectively. On the basis of XRD analysis the particle size of three stages of fruit ripening was found to range between 16.5 and 50.76 nm and all had silver metal which was confirmed by EDX. The inhibitory efficacy of AgNPs increased with the ripening progress such as ripened fruit > unripened fruit > young fruit against all tested human pathogenic microbes.

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“…is woody plant native to China, distributed throughout the country, that has been cultivated thousands of years there, and is now also grown across Asia, Europe, and the Americas ( Guo et al, 2011 ). Jujube fruit is sweet and rich in vitamin C. Accordingly, Chinese jujube has important economic value as a food and a resource for the production of medicines and other health-promoting products ( Shan et al, 2019 ; Rashwan et al, 2020 ; Sabri et al, 2021 ). Although there are extremely rich germplasm resources for jujube, the lack of improved varieties remains a limiting factor for its industrial development ( Chang, 2018 ; Liu P. et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Haplotype Analysis of Chloroplast Genomes for Jujube Breeding

Guo

et al. 2022

Front. Plant Sci.

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Jujube (family Rhamnaceae) is an important economic fruit tree in China. In this study, we reported 26 chloroplast (cp) sequences of jujube using Illumina paired-end sequencing. The sequence length of cp genome was 161, 367–161, 849 bp, which was composed of a large single-copy region (89053–89437 bp) and a small single-copy region (19356–19362 bp) separated by a pair of reverse repeat regions (26478–26533 bp). Each cp genome encodes the same 130 genes, including 112 unique genes, being quite conserved in genome structure and gene sequence. A total of 118 single base substitutions (SNPs) and 130 InDels were detected in 65 jujube accessions. Phylogenetic and haplotype network construction methods were used to analyze the origin and evolution of jujube and its sour-tasting relatives. We detected 32 effective haplotypes, consisting of 20 unique jujube haplotypes and 9 unique sour–jujube haplotypes. Compared with sour–jujube, jujube showed greater haplotype diversity at the chloroplast DNA level. To cultivate crisp and sweet fruit varieties featuring strong resistance, by combining the characteristics of sour-jujube and cultivated jujube, three hybrid combinations were suggested for reciprocal crosses: “Dongzao” × “Jingzao39,” “Dongzao” × “Jingzao60,” “Dongzao” × “Jingzao28.” This study provides the basis for jujube species’ identification and breeding, and lays the foundation for future research.

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Bound polyphenol extracted from jujube pulp triggers mitochondria-mediated apoptosis and cell cycle arrest of HepG2 cell in vitro and in vivo

Cited by 12 publications

References 37 publications

Review of Distribution, Extraction Methods, and Health Benefits of Bound Phenolics in Food Plants

Review of Distribution, Extraction Methods, and Health Benefits of Bound Phenolics in Food Plants

Silver nanoparticles from Ziziphus spina-christi (L.) Desf. fruits extract and their antimicrobial activity

Haplotype Analysis of Chloroplast Genomes for Jujube Breeding

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