PurposeThis paper aims to analyze the mechanism underlying the impact of boundary-spanning search (BS) on the sustainable development ability (SDA) of service-oriented manufacturing enterprises and to emphasize the intermediary role of knowledge integration (KI). The moderating role of knowledge inertia on the link between BS and KI is also investigated.Design/methodology/approachThis study constructs direct, mediating and moderating effects, selects 110 service-oriented manufacturing enterprises as research samples and obtains empirical data from questionnaires and annual reports. Among them, triangulation is skilfully used to obtain questionnaire data, and the regression method is used to test model relationships.FindingsThe results show that BS not only directly enhances SDA but also indirectly affects it through KI, which plays a mediating role in the impact of BS on SDA. In addition, knowledge inertia negatively moderates the relationship between BS and KI.Originality/valueThis paper makes three contributions. First, it enriches the research on the antecedent variables related to the SDA of service-oriented manufacturing enterprises. Second, by examining the mediating role of KI and the moderating role of knowledge inertia, the relationship between BS and SDA is revealed. Third, the research on knowledge management related to the SDA of service-oriented manufacturing enterprises is expanded.