Bovine digital dermatitis: Current concepts from laboratory to farm

Evans, Nicholas J.; Murray, Richard D.; Carter, S.D.

doi:10.1016/j.tvjl.2015.10.028

Cited by 85 publications

(94 citation statements)

References 96 publications

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“…The situation in New Zealand, as well as some other similar observations in other countries, has led to the hypothesis that DD becomes an increasingly important issue when dairy cattle management changes from a more extensive pasture‐based system to confinement freestall housing (Sogstad, Fjeldaas, Osteras, & Forshell, ). In countries like the UK, where cattle have housed and pasture seasons, the disease is almost restricted to the housing season (Evans et al., ). There is a need to further test this hypothesis in well‐designed studies along with an effort to better understand the potential drivers of this disease progression.…”

Section: Geographical Distributionmentioning

confidence: 99%

“…For a detailed overview of the findings of this body of knowledge, readers are directed to the review articles referenced at the start of this manuscript; however, two consistent themes have emerged from these studies. First, DD lesions are consistently associated with an abundant and diverse population of multiple species of treponemes (Evans et al., ; Krull et al., ; Zinicola et al., ). Second, these diverse treponeme populations exist as a portion of a much more diverse and complex bacterial community that comprises the total microbiota of the DD lesions.…”

Section: Pathogens Involvedmentioning

confidence: 99%

“…As seen in the UK, veterinarians and farmers' attitudes towards DD have been considerably influenced by the knowledge that the DD‐associated treponemes are implicated in the aetiopathogenesis of many lesions outside of cattle feet. Consequently, any effective treatments or control measures for bovine DD are likely to have additive beneficial effects (Evans et al., ).…”

Section: Role Of the Dairy Producer In Control Of Digital Dermatitismentioning

confidence: 99%

“…Consistency in scoring methodology would be much needed for scientific comparison of study results. A number of recent review articles have summarized the current understanding of the bacterial agents, epidemiology, therapy and treatment of digital dermatitis in detail in the last 2 years (Evans, Murray, & Carter, ; Palmer & O'Connell, ; Plummer & Krull, ; Wilson‐Welder, Alt, & Nally, ). The goal of this manuscript as part of the DISCONTOOLS collection is to identify and discuss significant knowledge gaps that should be addressed by the research community in order to propel the field and to drive the development of novel and effective intervention strategies for controlling this disease.…”

Section: Introduction To the Diseasementioning

confidence: 99%

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Missing pieces of the puzzle to effectively control digital dermatitis

Orsel

Plummer

Shearer

et al. 2017

Transbound Emerg Dis

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Since the first report of bovine digital dermatitis (DD) in 1974, there is a large body of the literature published; however, effective prevention and control of the disease remain elusive. Although many aspects of the pathogenesis of DD have been investigated, even some of the most basic questions such as the aetiology of this disease remain under debate. Treponema spp. have been strongly associated with DD lesions and occur in abundance in advanced lesions; however, efforts to induce disease with pure cultures of these organisms have been largely underwhelming and inconsistent. Furthermore, although the disease has been presented for several decades, there is limited scientific evidence regarding effective treatment of DD. Apparent discrepancies between effectiveness in vitro and in vivo have challenged the scientific community to identify new potential treatment options. With no treatment resulting in a 100% cure rate, the current expectation is manageable control, but prospects for the eradication of the disease are unlikely using current approaches. In order to develop more effective approaches to control DD on-farm, there is a critical need for a deeper understanding regarding the causation, ecology, transmission and treatment of this disease. In this article, we attempt to provide insights into specific research needs related to DD in order to assist the industry, researchers, pharmaceutical companies and research sponsors with decision-making and identified research gaps.

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Section: Geographical Distributionmentioning

confidence: 99%

Section: Pathogens Involvedmentioning

confidence: 99%

Section: Role Of the Dairy Producer In Control Of Digital Dermatitismentioning

confidence: 99%

Section: Introduction To the Diseasementioning

confidence: 99%

See 2 more Smart Citations

Missing pieces of the puzzle to effectively control digital dermatitis

Orsel

Plummer

Shearer

et al. 2017

Transbound Emerg Dis

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“…The genus Treponema includes both commensal and pathogenic spirochetes, some of which cause human illnesses such as yaws, pinta and syphilis (Radolf, 1996;Giacani and Lukehart, 2014). Certain Treponema species are also implicated in polymicrobial infections in humans and animals, such as periodontitis and bovine digital dermatitis [for reviews, see (Giacani and Lukehart, 2014;Evans et al, 2016)]. Since a majority of treponemal species cannot be reliably cultivated in vitro, the oral spirochete Treponema denticola, which can be cultivated, has been used as a model organism to understand the biology and pathogenicity of the treponemes (Chi et al, 1999;Anand et al, 2013;Bian et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

A novel glycan modifies the flagellar filament proteins of the oral bacterium Treponema denticola

Kurniyati

Kelly

Vinogradov

et al. 2016

Molecular Microbiology

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While protein glycosylation has been reported in several spirochetes including the syphilis bacterium Treponema pallidum and Lyme disease pathogen Borrelia burgdorferi, the pertinent glycan structures and their roles remain uncharacterized. Herein, we report a novel glycan with an unusual chemical composition and structure in the oral spirochete Treponema denticola, a keystone pathogen of periodontitis. The identified glycan of mass 450.2 Da is composed of a monoacetylated nonulosonic acid (Non) with a novel extended N7 acyl modification, a 2-methoxy-4,5,6-trihydroxy-hexanoyl residue in which the Non has a pseudaminic acid configuration (L-glycero-L-manno) and is β-linked to serine or threonine residues. This novel glycan modifies the flagellin proteins (FlaBs) of T. denticola by O-linkage at multiple sites near the D1 domain, a highly conserved region of bacterial flagellins that interact with Toll-like receptor 5. Furthermore, mutagenesis studies demonstrate that the glycosylation plays an essential role in the flagellar assembly and motility of T. denticola. To our knowledge, this novel glycan and its unique modification sites have not been reported previously in any bacteria.

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Gram‐Negative Anaerobes

Prescott¹

2022

Pathogenesis of Bacterial Infections in Animals

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Bovine digital dermatitis: Current concepts from laboratory to farm

Cited by 85 publications

References 96 publications

Missing pieces of the puzzle to effectively control digital dermatitis

Missing pieces of the puzzle to effectively control digital dermatitis

A novel glycan modifies the flagellar filament proteins of the oral bacterium Treponema denticola

Gram‐Negative Anaerobes

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