Bovine haemoglobin is more potent than autologous red blood cells in restoring muscular tissue oxygenation after profound isovolaemic haemodilution in dogs

Standl, Thomas; Horn, Patrick; Wilhelm, Stefan; Greim, Clemens‐Alexander; Freitag, M.; Freitag, U.; Sputtek, Andreas; Jacobs, Edward E.; Esch, Jochen Schulte am

doi:10.1007/bf03017957

Cited by 114 publications

(102 citation statements)

References 33 publications

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“…Neither parameter returned to the prehemodilution value. These results confirm those of Standl et al 4 in a similar study of an anemic dog model.…”

supporting

confidence: 93%

“…2 Despite the need for adjustments in our current clinical practice, Oxyglobin has become a frequently used product in canine transfusion medicine and is being investigated in other species. 3,4 In this issue of the Journal of Veterinary Internal Medicine, Belgrave et al 3 report on the complex physiologic interactions among arterial oxygen content, cardiac output, blood pressure, oxygen delivery, and oxygen extraction in anemic normal ponies treated with Oxyglobin compared with hetastarch. Normovolemic anemia was induced, decreasing arterial oxygen content.…”

mentioning

confidence: 99%

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Editorial: Oxyglobin: A Transfusion Solution?

Hohenhaus

2002

Veterinary Internal Medicne

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“…Neither parameter returned to the prehemodilution value. These results confirm those of Standl et al 4 in a similar study of an anemic dog model.…”

supporting

confidence: 93%

mentioning

confidence: 99%

Editorial: Oxyglobin: A Transfusion Solution?

Hohenhaus

2002

Veterinary Internal Medicne

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“…This phenomenon was accompanied by a large increase in systemic O 2 extraction, from baseline. In another study, the same investigators further reduced systemic Hct to 5% before infusion of PBH and found a similar increase in tissue PO 2 (25,26). These studies by Standl et al introduced PBH in concentrations ranging from 1.5 to 7.2 g/dl, and, similar to the current study, the lower concentrations overcame the negative effects of vasoconstriction associated with this material and increased the O 2 delivery.…”

Section: Discussionmentioning

confidence: 77%

“…Other studies have reported similar results. Standl et al (25) subjected dogs to isovolemic hemodilution with 6% hetastarch, reducing their Hct to 10%, then augmenting their Hb level with PBH. They found that mean tissue PO 2 measured with a needle electrode increased after transfusion compared with nontreated animals.…”

Section: Discussionmentioning

confidence: 99%

Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction

Cabrales¹,

Tsai²,

Intaglietta³

2008

American Journal of Physiology-Heart and Circulatory Physiology

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Cabrales P, Tsai AG, Intaglietta M. Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction. Am J Physiol Heart Circ Physiol 295: H2212-H2218, 2008. First published October 3, 2008 doi:10.1152/ajpheart.00751.2008.-O 2-carrying fluids based on hemoglobin (Hb) are in various stages of clinical trials to determine their suitability as O 2-carrying plasma expanders. Polymerized Hb solutions are characterized by their vasoactivity, low O 2 affinity, oncotic effect, prolonged shelf life, and stability. Physiological responses to facilitated O 2 transport after exchange transfusion with polymerized bovine Hb (PBH) were studied in the hamster window chamber model during acute moderate anemia to determine how PBH affects microvascular perfusion and tissue oxygenation. The anemic state [29% hematocrit (Hct)] was induced by hemodilution with a plasma expander (70 kDa dextran). After hemodilution, animals were randomly assigned to different exchange transfusion groups. Study groups were based on the concentration of PBH used, namely: PBH at 13 g Hb/dl [PBH13], PBH diluted to 8 (PBH8) or 4 (PBH4) g Hb/dl in albumin solution at matching colloidal osmotic pressure (COP), and no PBH (only albumin solution) at matching COP (PBH0). Measurement of systemic parameters, microvascular hemodynamics, capillary perfusion, and intravascular and tissue O 2 levels was performed at 18% Hct. Restitution of O2-carrying capacity with PBH13 increased arterial pressure and triggered vasoconstriction, low perfusion, and high peripheral resistance. PBH4 and PBH0 exhibited lower arterial pressures compared with PBH13. Exchange transfused animals with PBH8 and PBH4 better maintained perfusion and functional capillary density than PBH13. Blood gas parameters and acid-base balance were recovered proportional to microvascular perfusion. Arterial O 2 tensions were improved with PBH4 and PBH8 by preventing O 2 precapillary release and increasing O2 reserve. Further studies to establish PBH optimal dosage, efficacy, safety, and its effect on outcome are indicated before Hb-based O 2-carrying blood substitutes are implemented in routine practice. microcirculation; red blood cells; hemodilution; functional capillary density; hemoglobin oxygen affinity; tissue oxygen.BLOOD SUBSTITUTES ARE in continued development, driven in part by the public perception that the blood supply is not safe and looming shortages (18). However, blood safety, related to the transmission of viral diseases, is no longer a major concern in the United States, and blood shortages have not materialized due to continued development of surgical techniques that reduce blood losses and lower transfusion triggers (18). Despite these advances, the development of effective blood substitutes that maintain blood volume (BV) and deliver O 2 remains a priority for emergency combat care, as well as for severe blood losses associated with trauma. Blood is a vital public health resource that must be read...

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“…Moreover, the oxygen-dissociation curve for HBOC-201 was shifted to the right relative to human hemoglobin, meaning that HBOC-201 was more able to unbind oxygen in the periphery and release it to the target organs. Standl et al [22,23] compared HBOC with autologous blood as resuscitation for dogs after massive blood loss. They found that the increase in skeletal muscle tissue oxygen tension per gram of transfused hemoglobin was higher after HBOC transfusion than after autologous RBC transfusion.…”

Section: Properties Of Hboc-201mentioning

confidence: 99%