Bovine leukemia virus integration site selection in cattle that develop leukemia

Murakami, Hironobu; Yamada, T.; Suzuki, Miho; Nakahara, Yü̅suke; Suzuki, Kazuhiko; Sentsui, Hiroshi

doi:10.1016/j.virusres.2011.01.004

Cited by 54 publications

(49 citation statements)

References 30 publications

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“…Bovine leukaemia virus (BLV) is a ubiquitous oncogenic deltaretrovirus, responsible for enzootic bovine leukosis (EBL), a chronic lymphoproliferative disease in cattle (14,15,30). The virus has a genomic organisation similar to human T-cell leukaemia virus (HTLV-1).…”

Section: Introductionmentioning

confidence: 99%

Selected biochemical and oxidative stress parameters and ceruloplasmin as acute phase protein associated with bovine leukaemia virus infection in dairy cows

Akalın

Ataseven

Doğan

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

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The aim of this study was to determine the ceruloplasmin (Cp) and vitamin C concentrations, the total antioxidant status (TAS), and selected biochemical parameters in dairy cows spontaneously infected with bovine leukaemia virus (BLV). Of the 27 cows included in the study, 18 animals were seropositive for enzootic bovine leukosis (EBL), whereas nine cows were seronegative and were used as controls. The serum aspartate aminotransferase (AST) (P = 0.003) and Cp concentrations (P = 0.03) decreased (65.17 ± 5.03 and 7.70 ± 0.72 respectively) in BLV-infected cows, as compared to healthy animals (100.67 ± 11.50 and 10.40 ± 0.70 respectively). A slight insignificant increase in alkaline phosphatase activity and unchanged levels of alanine aminotransferase, lactate dehydrogenase, calcium, magnesium, and TAS were demonstrated in EBL cows. As the TAS and vitamin C levels remained unchanged in EBL cows, it may be suggested that ruminants may compensate for the impaired oxidative/antioxidative balance. The results obtained also indicate that BLV may suppress AST and Cp synthesis or secretion in the liver through an unknown mechanism. The mechanism of action of BLV in hepatocytes, especially on AST and Cp, requires further investigation to elucidate the immune suppression caused by oncogenic retroviruses.

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Section: Introductionmentioning

confidence: 99%

Selected biochemical and oxidative stress parameters and ceruloplasmin as acute phase protein associated with bovine leukaemia virus infection in dairy cows

Akalın

Ataseven

Doğan

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

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“…It presents on infected animals and it is associated with a persistent lymphocytosis characterized by the nonmalignant polyclonal expansion of B-cells. From these animals, 5% of them develops a leukemia or a lymphoma [6,7]. Besides of infecting cattle, some other authors have proposed the possibility of transmission to other species, including humans [8].…”

Section: Introductionmentioning

confidence: 99%

“…Some time ago, it was proposed that BLV did not have oncogenes, it was not found a place of insertion into the cell genome and was proposed that the provirus did not have a replicative cycle in tumor cells [6]. Furthermore, Murakami et al, showed that this provirus is not inserted in a particular chromosome, but it does in introns located far away from transcription factors starters [7]. Otherwise, Takahashi states that Tax protein cooperates with a viral oncoprotein to generate transformation in a mouse cell line, suggesting that in addition of having a regulatory function in the viral replication, it could induce leukemia in bovine cattle infected with BLV [9].…”

Section: Introductionmentioning

confidence: 99%

Bovine Leukemia Virus Gene Segment Detected in Human Breast Tissue

Giovanna¹,

Carlos²,

María³

et al. 2013

OJMM

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Background: Bovine Leukemia Virus (BLV) is known by infections in bovine cattle and produce, in 30% of infected animals, persistent lymphocytosis significantly impacts the beef industry. It has been proposed that this virus could be transmitted to humans and be present in cases of breast cancer. Aim: to determine the presence of 380 bp of gag gene segment of BLV in paraffin-embedded breast tissue. Study Design: Control-case study. Methodology: 106 tissue samples were collected. 53 were cancer positive samples and 53 were negative samples for this pathology. After dewaxing tissues, DNA was extracted, amplified and sequenced. Phylogenetic analysis was done in order to verify BLV gene segment, presence and origin. Results: 43 samples were positive (40.5%) for BLV segment. In the case group this segment was found in 35.8% of the samples and in the control group, BLV presented in 45.2% of the samples. Phylogenetic analysis confirmed BLV presence and had shown a high homology between amplified gene sequences obtained from human breast tissues and those coming from bovine cattle with leukosis reported by GenBank. Conclusion: The presence of BLV genes in humans and its location in breast tissue can be confirmed, however, it should be clarified as a possible promoter of malignancy processes on this tissue.

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“…O VLB infecta principalmente linfócitos B , integrando seu genoma em regiões dispersas do genoma da célula hospedeira (Murakami et al, 2011b). Infectado, o animal pode apresentar-se com sorodiagnóstico positivo, sem a presença de linfocitose persistente (LP), ou com sorodiagnóstico positivo apresentando LP, caracterizado por uma elevação crônica no número de linfócitos B circulantes, encontrado em cerca de 30% dos bovinos infectados (Parodi, 1987) e considerado, por diversos autores, como uma manifestação benigna da enfermidade (Murakami et al, 2011a).…”

Section: Introductionunclassified

Avaliação funcional de monócitos de bovinos naturalmente infectados pelo vírus da leucose bovina

Azedo

Blagitz

Souza

et al. 2011

Arq. Bras. Med. Vet. Zootec.

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RESUMOPara a avaliação funcional de monócitos de bovinos infectados pelo vírus da leucose enzoótica bovina (LEB), foram coletadas amostras de sangue de 10 vacas com sorodiagnóstico negativo (SN), 10 com sorodiagnóstico positivo e que manifestavam linfocitose persistente (LP), e 10 com sorodiagnóstico positivo alinfocitóticas (AL ABSTRACT Assuming that the bovine leukosis virus (BLV) alters quantitatively and qualitatively bovine circulating leukocyte subpopulations, thus influencing the innate immune response, monocytes function in BLVinfected cattle was assessed. Peripheral blood was obtained from 10 BLV-negative cows (SN), 10 naturally BLV-infected, non-lymphocytotic cows (AL), and 10 BLV-infected cows with persistent lymphocytosis (PL

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Bovine leukemia virus integration site selection in cattle that develop leukemia

Cited by 54 publications

References 30 publications

Selected biochemical and oxidative stress parameters and ceruloplasmin as acute phase protein associated with bovine leukaemia virus infection in dairy cows

Selected biochemical and oxidative stress parameters and ceruloplasmin as acute phase protein associated with bovine leukaemia virus infection in dairy cows

Bovine Leukemia Virus Gene Segment Detected in Human Breast Tissue

Avaliação funcional de monócitos de bovinos naturalmente infectados pelo vírus da leucose bovina

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