Bowen's Disease

Abstract

Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the “lull before the storm,” which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis. Immunohistochemistry, dermoscopy, and reflectance confocal microscopy are the adjuvant modalities used in the diagnosis of BD. The treatment depends on various factors like site, size, immune status, patient's age, esthetic outcome, etc. The available therapeutic modalities include topical chemotherapy, surgical modalities, light-based modalities, and destructive therapies. It requires a combined effort of dermatologist, oncosurgeon, and plastic surgeon to plan and execute the management in various presentations of BD.

Knowledge and awareness about Bowen's disease among dental students

“…Bowen's disease, which turns out to be a precancerous condition of squamous cell carcinoma, is a rare disease but one of the major types of skin cancer. [ 21 ] When asked if Bowen's disease was hereditary, 21–30 years old said they were hereditary (41.88%) [ Figure 5 ]. Bowen's disease is a noninvasive precancerous condition, also known as intraepithelial squamous cell carcinoma, but our findings show that approximately 44.02% of the 21–30-year-old age group is an invasive form which was contraindicated [ Figure 6 ].…”

Bowen's Disease: Literature Review

“…При этом запускаются такие механизмы, как инактивация генов, подавляющих р53, которые, в свою очередь, вызывают агрессивное развитие злокачественных новообразований кожи и в первую очередь болезни Боуэна [12]. Некоторые вторичные причины возникновения (различные виды повреждения и воспалительные процессы в коже) могут спровоцировать болезнь Боуэна, особенно у пожилых людей [13].…”

“…Что касается современных методов лечения болезни Боуэна, то указать конкретный наиболее эффективный метод терапии, к сожалению, нельзя. Согласно зарубежным клиническ им рекомендациям, можно использовать несколько различных методов лечения [10,13]. Специфическое лечение в каждом конкретном случае зависит от множества факторов.…”

Genomic landscape of multiple Bowenʼs disease using whole‐exome sequencing

“…Patients with BD have an increased risk of developing invasive cSCC 3 . Approximately 10%–20% of patients with BD may develop multiple lesions 4 . Although recent studies have revealed the genomic landscape of BD, 5–7 few studies have evaluated the genomics of multiple BD.…”

“…3 Approximately 10%-20% of patients with BD may develop multiple lesions. 4 Although recent studies have revealed the genomic landscape of BD, 5-7 few studies have evaluated the genomics of multiple BD. A case of multiple BD with cancer-predisposing Li-Fraumeni syndrome caused by a germline TP53 mutation 8 and a case series of multiple BD with different TP53 somatic mutations have been reported, 9…”