BOX: A water-soluble tetraanionic rectangular molecular container for conjugated molecules and taste masking for berberine and palmatine

Lin, Qihan; Xing, Jiabin; Liu, Yue-Yang; Wu, Gang; Liu, Shi-Jia; Wang, Hui; Zhou, Wei; Li, Zhan-Ting; Zhang, Dan-Wei

doi:10.1016/j.cclet.2023.109119

Chinese Chemical Letters

2024

DOI: 10.1016/j.cclet.2023.109119

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BOX: A water-soluble tetraanionic rectangular molecular container for conjugated molecules and taste masking for berberine and palmatine

Qihan Lin,

Jiabin Xing,

Yue-Yang Liu

et al.

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Sulfonated Azocalix[4]arene: A Universal and Effective Taste-Masking Agent

Chen,

Lin,

Wang

et al. 2024

ACS Appl. Mater. Interfaces

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Many active pharmaceutical ingredients have a specific bitter taste. To enhance patient compliance and treatment efficacy, taste-masking agents are crucial in oral drug formulations. Confronting numerous bitter drug molecules with varied structures, the pharmaceutical field strives to explore and develop universal and effective masking approaches. Here, we reported sulfonated azocalix[4]arene (SAC4A), a universal supramolecular masking agent with deep cavity that provides stronger hydrophobic effect and larger interaction area during recognition, allowing high binding affinity to bitter drug molecules. Moreover, bitter drugs could deeply buried in the cavity, with the bitterness effectively masked. As a result, SAC4A can bind to 16 different bitter drugs with high affinities, encompassing alkaloids, flavonoids, terpenoids, and more, while maintaining high biocompatibility. As anticipated, SAC4A effectively masks the unpalatable bitter taste associated with these drugs. Consequently, SAC4A is a promising universal and effective supramolecular masking agent.

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Sulfonated Azocalix[4]arene: A Universal and Effective Taste-Masking Agent

Chen,

Lin,

Wang

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

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BOX: A water-soluble tetraanionic rectangular molecular container for conjugated molecules and taste masking for berberine and palmatine

Cited by 1 publication

References 42 publications

Sulfonated Azocalix[4]arene: A Universal and Effective Taste-Masking Agent

Sulfonated Azocalix[4]arene: A Universal and Effective Taste-Masking Agent

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