Box–Behnken factorial design to obtain a phenolic-rich extract from the aerial parts of Chelidonium majus L.

Grosso, Clara; Ferreres, Federico; Gil‐Izquierdo, Ángel; Valentão, Patrı́cia; Sampaio, Maria J.; Lima, J. J. G.; Andrade, Paula B.

doi:10.1016/j.talanta.2014.06.043

Cited by 31 publications

(23 citation statements)

References 35 publications

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“…Hydroxycinnamic acids (caffeic, p-coumaric, ferulic) and their derivatives ((–)-2-( E )-caffeoyl- D -glyceric acid [46], (–)-4-( E )-caffeoyl- L -threonic acid [47], (–)-2-( E )-caffeoyl- L -threonic acid lactone, (+)-( E )-caffeoyl- L -malic acid [48]), as well as hydroxybenzoic acids (genistic, p-hydroxybenzoic) were identified in aerial parts (Hahn and Nahrstedt, 1993 ; Wojdyło et al, 2007 ). Later, another three hydroxycinnamic acids were identified using HPLC-DAD-ESI/MS: caffeoyl threonic acid, caffeoyl glyceric acid, caffeoylmalic acid (Grosso et al, 2014 ), that have been detected previously by Hahn and Nahrstedt ( 1993 ). Two caffeoyl acid derivatives isomers with precursor ions at m/s 359 corresponding to rosmarinic acid were also found in aerial parts (Grosso et al, 2014 ).…”

Section: Phytochemistrymentioning

confidence: 96%

“…Generally, five groups of alkaloids were found in C. majus . These are the derivatives of phenanthridine (3,4-benzoisoquinoline), protoberberine, protopine [37], quinolizidine, aporphine (Kadan et al, 1990 , 1992 ; Pavao and Pinto, 1995 ; Táborská et al, 1995 ; Petruczynik et al, 2002 ; Nečas et al, 2005 ; Sārközi et al, 2006 ; Zhou et al, 2012 ; Kedzia et al, 2013 ; Grosso et al, 2014 ; Poormazaheri et al, 2017 ). More than forty alkaloids of different types were isolated and identified from C. majus (Figures 1 – 7 ).…”

Section: Phytochemistrymentioning

confidence: 99%

“…Four diglycosides and five monoglycosides were identified as derivatives of kaempferol, quercetin, and isorhamnetin (kaempferol-3- O -rutinoside, quercetin-3- O -rutinoside, isorhamnetin-3- O -glucoside). The identification was based on the mass spectra of the compounds (Grosso et al, 2014 ). In stems, leaves, and flowers, 5′-methoxy-flavonol [43] and 6′- methoxy-flavonol [44] were also detected (Stancic-Rotaru et al, 2003 ).…”

Section: Phytochemistrymentioning

confidence: 99%

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Greater Celandine's Ups and Downs−21 Centuries of Medicinal Uses of Chelidonium majus From the Viewpoint of Today's Pharmacology

et al. 2018

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As antique as Dioscorides era are the first records on using Chelidonium as a remedy to several sicknesses. Inspired by the “signatura rerum” principle and an apparent ancient folk tradition, various indications were given, such as anti-jaundice and cholagogue, pain-relieving, and quite often mentioned—ophthalmological problems. Central and Eastern European folk medicine has always been using this herb extensively. In this region, the plant is known under many unique vernacular names, especially in Slavonic languages, associated or not with old Greek relation to “chelidon”—the swallow. Typically for Papaveroidae subfamily, yellow-colored latex is produced in abundance and leaks intensely upon injury. Major pharmacologically relevant components, most of which were first isolated over a century ago, are isoquinoline alkaloids—berberine, chelerythrine, chelidonine, coptisine, sanguinarine. Modern pharmacology took interest in this herb but it has not ended up in gaining an officially approved and evidence-based herbal medicine status. On the contrary, the number of relevant studies and publications tended to drop. Recently, some controversial reports and sometimes insufficiently proven studies appeared, suggesting anticancer properties. Anticancer potential was in line with anecdotical knowledge spread in East European countries, however, in the absence of directly-acting cytostatic compounds, some other mechanisms might be involved. Other properties that could boost the interest in this herb are antimicrobial and antiviral activities. Being a common synanthropic weed or ruderal plant, C. majus spreads in all temperate Eurasia and acclimates well to North America. Little is known about the natural variation of bioactive metabolites, including several aforementioned isoquinoline alkaloids. In this review, we put together older and recent literature data on phytochemistry, pharmacology, and clinical studies on C. majus aiming at a critical evaluation of state-of-the-art from the viewpoint of historical and folk indications. The controversies around this herb, the safety and drug quality issues and a prospective role in phytotherapy are discussed as well.

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Section: Phytochemistrymentioning

confidence: 96%

Section: Phytochemistrymentioning

confidence: 99%

Section: Phytochemistrymentioning

confidence: 99%

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Greater Celandine's Ups and Downs−21 Centuries of Medicinal Uses of Chelidonium majus From the Viewpoint of Today's Pharmacology

et al. 2018

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“…On the present study, a three level Box-Behnken experimental design with a response surface methodology (Baş & Boyacı, 2007;Grosso et al, 2014;Sharmila et al, 2016) was employed to optimize the UAE extraction conditions. The total amount of extracted anthocyanins and the total amount of phenolic compounds were considered as the response variables.…”

Section: Experimental Design and Optimizationmentioning

confidence: 99%

Optimization of ultrasound-assisted extraction of bioactive compounds from jabuticaba (Myrciaria cauliflora) fruit through a Box-Behnken experimental design

et al. 2019

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Jabuticaba is a very popular fruit in Brazil being a great source of compounds with considerable biological activities. Novel optimized ultrasound-assisted extraction (UAE) methods have been proposed for anthocyanins and total phenolic compounds from jabuticaba. A Box-Behnken experimental design (BBD) with a response surface methodology (RSM) was used to investigate the effect of six independent variables (solvent composition, solvent-to-sample ratio, ultrasound amplitude and cycle, pH, and temperature) on the UAE. Solvent composition was found to be the most significant variable for the extraction of both anthocyanins (51%) and total phenolic compounds (72%). The other optimum conditions for anthocyanins were as follows: pH 7.00, 39.8 ºC, 20:1.5 mL:g solvent-to-sample ratio, 34% ultrasound amplitude and cycle of 0.47 seconds. The optimum conditions for the extraction of phenolic compounds were: pH 7.00, 26.0 ºC, 20:1.5 (mL:g) solvent-to-sample ratio, 68.5% ultrasound amplitude and cycle of 0.5 seconds. The extraction kinetic was also evaluated. The developed methods showed a high precision, with coefficients of variation of less than 5% for both repeatability and intermediate precision (within-lab reproducibility). The applicability of the new methods was successfully evaluated on several fruits and jams from jabuticaba.

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“…CA showed inhibitory effects on interleukin-6 production by blocking NF-kB and caspase-1 in HMC-1 cells (Shin et al, 2011). Fifteen phenolic compounds were identified from the aerial parts of C. majus (Grosso et al, 2014), including nine new flavonoids and three new hydroxycinnamic acids. Fifteen phenolic compounds were identified from the aerial parts of C. majus (Grosso et al, 2014), including nine new flavonoids and three new hydroxycinnamic acids.…”

Section: Other Compoundsmentioning

confidence: 98%

Phytochemical and biological research of Chelidonieae pharmaceutical resources

Hao¹,

Gu²,

Xiao³

2015

Medicinal Plants

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Box–Behnken factorial design to obtain a phenolic-rich extract from the aerial parts of Chelidonium majus L.

Cited by 31 publications

References 35 publications

Greater Celandine's Ups and Downs−21 Centuries of Medicinal Uses of Chelidonium majus From the Viewpoint of Today's Pharmacology

Greater Celandine's Ups and Downs−21 Centuries of Medicinal Uses of Chelidonium majus From the Viewpoint of Today's Pharmacology

Optimization of ultrasound-assisted extraction of bioactive compounds from jabuticaba (Myrciaria cauliflora) fruit through a Box-Behnken experimental design

Phytochemical and biological research of Chelidonieae pharmaceutical resources

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