Bracken ptaquiloside in milk

Alonso‐Amelot, Miguel E.; Castillo, Uvidelio; Smith, Barry L.; Lauren, D. R.

doi:10.1038/382587a0

Cited by 90 publications

(53 citation statements)

References 6 publications

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“…Exposure to ptaquiloside indirectly through milk from bracken-grazing cows has a big impact on human health, since it has been correlated with human oesophageal and gastric cancer [3,122,139]. In different parts of the world the human consumption of bracken has been linked to GI cancer [2,3,82]. HPV-16 DNA has been found in high percentage in oesophageal cancer particularly in developing countries where the consumption of bracken or milk from bracken fed cows is high [79,84].…”

Section: Bracken Fern As a Cofactor For Carcinogenesismentioning

confidence: 99%

Bovine papillomaviruses, papillomas and cancer in cattle

Borzacchiello¹,

Roperto²

2008

Vet. Res.

173

149

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-Bovine papillomaviruses (BPV) are DNA oncogenic viruses inducing hyperplastic benign lesions of both cutaneous and mucosal epithelia in cattle. Ten (BPV 1-10) different viral genotypes have been characterised so far. BPV 1-10 are all strictly species-specific but BPV 1/2 may also infect equids inducing fibroblastic tumours. These benign lesions generally regress but may also occasionally persist, leading to a high risk of evolving into cancer, particularly in the presence of environmental carcinogenic co-factors. Among these, bracken fern is the most extensively studied. The synergism between immunosuppressants and carcinogenic principles from bracken fern and the virus has been experimentally demonstrated for both urinary bladder and alimentary canal cancer in cows whose diets were based on this plant. BPV associated tumours have veterinary and agricultural relevance in their own right, although they have also been studied as a relevant model of Human papillomavirus (HPV). Recent insights into BPV biology have paved the way to new fields of speculation on the role of these viruses in neoplastic transformation of cells other than epithelial ones. This review will briefly summarise BPV genome organization, will describe in greater detail the functions of viral oncoproteins, the interaction between the virus and co-carcinogens in tumour development; relevant aspects of immunity and vaccines will also be discussed.

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Section: Bracken Fern As a Cofactor For Carcinogenesismentioning

confidence: 99%

Bovine papillomaviruses, papillomas and cancer in cattle

Borzacchiello¹,

Roperto²

2008

Vet. Res.

173

149

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“…Já foi demonstrado que o leite proveniente de vacas que se alimentam regularmente de brotos de samambaia, contém ptaquilosídeo e causa câncer em roedores (EVANS et al, 1972). A concentração do ptaquilosídeo no leite corresponde a 8,5% da quantidade ingerida pelo animal (ALONSO-AMELOT et al,1996). A associação entre a ingestão de leite de animais alimentados com broto de samambaia e o desenvolvimento de neoplasias foi comprovada experimentalmente em roedores (VILLALOBOS-SALAZAR et al, 1990).…”

Section: Intoxicação Humanaunclassified

Toxicidade da samambaia (Pteridium aquilinum (L.) Kuhn) para a saúde animal e humana

Cruz

Bracarense

2004

Sem. Ci. Agr.

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Toxicidade da samambaia (Pteridium aquilinum (L.) Kuhn) para a saúde animal e humana ResumoO artigo revisa algumas das principais características da planta Pteridium aquilinum (samambaia) bem como as conseqüências da sua ingestão por animais de produção, animais de laboratório e pelo próprio homem. O composto ptaquilosídeo encontrado na planta é considerado atualmente o principal responsável pelo aparecimento de neoplasias. No homem, existem três maneiras pelo qual este pode ser intoxicado: ingestão da planta, contato físico (inalação dos esporos ou ingestão de água contaminada) e ingestão de leite cru de animais que ingeriram a planta. Palavras-chave: Pteridium aquilinum, samambaia, neoplasia, homem. AbstractThe article reviews some of the main characteristics of Pteridium aquilinum (bracken fern) and the main consequences of its ingestion by livestock animals, laboratory animals and man. Ptaquiloside is considered the main responsible for the neoplasias in these cases. Three main routes may lead to human exposure to the toxic effects of bracken fern: eating the plant, physical contact (inhalation of the spores or ingestion of contaminated water) and ingestion of raw milk from affected animals.

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“…Some examples include indolizidine [14], piperidine [17], pyrrolizidine [7,19,30], and quinolizidine alkaloids [23], glucosinolates [10,11,28,38], sesquiterpene lactones [13], and ptaquilosides [1,9]. Although excretion of plant toxins through the mammary gland reduces the toxicity to lactating animals, it is an important source of such toxins to the consumer.…”

Section: Introductionmentioning

confidence: 99%

Milk transfer of cyanide and thiocyanate: Cyanide exposure by lactation in goats

Soto-Blanco¹,

Górniak

2003

Vet. Res.

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-The present work was aimed at evaluating the effects of maternal exposure to potassium cyanide (KCN) during lactation in goats. Twenty-seven lactating female goats were orally dosed with 0 (control), 1.0, 2.0, or 3.0 mg KCN/kg body weight/day from lactation days 0 to 90. After this period, all male kids and one mother from each group were killed for a pathological study. Cyanide treatment promoted the clinical signs of maternal toxicity in the highest KCN group but did not affect body weight. Both cyanide and thiocyanate presented increased levels in both dams and kids from the treated groups. Microscopic lesions, but without alterations on the biochemical panel, were found in the brain, thyroid, liver, and kidneys of both dams and kids from the treated groups. These findings suggest that lactating offspring can be indirectly intoxicated by maternal exposure to cyanide.cyanide / thiocyanate / milk / goat

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Bracken ptaquiloside in milk

Cited by 90 publications

References 6 publications

Bovine papillomaviruses, papillomas and cancer in cattle

Bovine papillomaviruses, papillomas and cancer in cattle

Toxicidade da samambaia (Pteridium aquilinum (L.) Kuhn) para a saúde animal e humana

Milk transfer of cyanide and thiocyanate: Cyanide exposure by lactation in goats

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