BRAF V600E mutations are not an oncogenic driver of solitary xanthogranuloma and reticulohistiocytoma: Testing may be useful in screening for Erdheim-Chester disease

Hoyt, Brian; Yan, Shaofeng; Linos, Konstantinos; Momtahen, Shabnam; Sriharan, Aravindhan; Tran, Tien-Anh; Tsongalis, Gregory J.; O'Meara, Rebecca R.; Green, Donald C.; LeBlanc, Robert E.

doi:10.1016/j.yexmp.2019.104320

Cited by 8 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Positive staining would strongly suggest a diagnosis of ECD and should prompt investigation for a systemic component. 23,25 Of note, cases of BRAF V600E-mutated XG have been described in the central nervous system such that some diagnostic uncertainty remains in that setting. 26,27 In our study, BRAF V600E staining was negative in all cases.…”

Section: Discussionmentioning

confidence: 99%

“…7,8,21,22 Localized cutaneous XGs do not exhibit BRAF V600E mutations, but they often show other activating mutations or fusions within the RTK or MAPK pathways. 11,13,23 In our study, we investigated cyclin D1 expression in XG to determine whether the findings in LCH and RDD also extend to XG. Twelve of our 15 cases (80%) showed strong cyclin D1 expression, whereas the remaining 3 cases showed only weak, focal staining.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Utility of Cyclin D1 Immunostaining in Cutaneous Xanthogranuloma

Sharma

McAfee

Wang³

et al. 2021

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase pathway activation has recently been found to be associated with almost all Langerhans cell histiocytosis cases. In BRAF V600E mutation-positive cases, this activation is seen as a downstream activation. In addition, cyclin D1 is a downstream target of the MAPK pathway. Recent studies have argued in favor of using cyclin D1 as a potential neoplastic marker to differentiate Langerhans cell histiocytosis from other reactive Langerhans cell proliferations in the skin and lymph nodes. Therefore, we chose to study the immunohistochemical expression of cyclin D1 in cutaneous xanthogranuloma (XG) cases. Fifteen XG cases were retrieved and stained for cyclin D1, BRAF (v-raf murine sarcoma viral oncogene homolog B1), CD1a, and langerin (CD207). Twelve cases showed strong and diffuse nuclear positivity for cyclin D1, both in the XG cells and in the multinucleated osteoclast-like giant cells. Three cases showed focal weak nuclear staining for cyclin D1. All 15 cases showed negative immunoreactivity for BRAF, CD1a, and CD207. Although limited by small sample size, we conclude that most cases of cutaneous XG should show at least weak nuclear staining with cyclin D1. The histogenesis of XG is still largely unknown, and the finding of cyclin D1 positivity in a majority of cases may indicate a role for the MAPK/extracellular signalregulated kinase pathway in cutaneous XG.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Utility of Cyclin D1 Immunostaining in Cutaneous Xanthogranuloma

Sharma

McAfee

Wang³

et al. 2021

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

Lung Tumors

Popper

2021

Pathology of Lung Disease

View full text Add to dashboard Cite

Pediatric Lymphoid and Histiocytic Lesions in the Head and Neck

Auerbach¹,

Schmieg²,

Aguilera

2021

Head and Neck Pathol

View full text Add to dashboard Cite

Lymphoid and histiocytic lesions of the head and neck in pediatric patients is a fascinating topic as most of these lesions are benign, but that the neoplastic cases are essential to diagnose accurately for appropriate treatment. It is thought that 90% of children will have palpable lymph nodes between the ages of 4 to 8; most, but not all, are non-malignant and some resolve spontaneously without treatment. This paper will look at many of the benign and malignant lesions of both lymphocytic and histiocytic origin that present in the head and neck of children focusing on their diagnostic criteria. There is a very pertinent discussion of nonmalignant lymphoid proliferations, as infections and other reactive conditions dominate the pathology of pediatric lymphohistiocytic head and neck lesions. Discussion of those lymphomas which arise more frequently in the head and neck focuses on those seen in children and young adults such as classic Hodgkin lymphoma and Burkitt lymphoma, as well as new more controversial entities such as pediatric-type follicular lymphoma. Histiocytic lesions, both benign and malignant, are described and may be challenging to diagnose.

show abstract

BRAF V600E mutations are not an oncogenic driver of solitary xanthogranuloma and reticulohistiocytoma: Testing may be useful in screening for Erdheim-Chester disease

Cited by 8 publications

References 24 publications

Utility of Cyclin D1 Immunostaining in Cutaneous Xanthogranuloma

Utility of Cyclin D1 Immunostaining in Cutaneous Xanthogranuloma

Lung Tumors

Pediatric Lymphoid and Histiocytic Lesions in the Head and Neck

Contact Info

Product

Resources

About