Brain 3D-SSP SPECT analysis in dementia with Lewy bodies, Parkinson's disease with and without dementia, and Alzheimer's disease

Mito, Yasunori; Yoshida, Kazuto; Yabe, Ichiro; Makino, Kenichi; Hirotani, Makoto; Tashiro, Kunio; Kikuchi, Seiji; Sasaki, Hidenao

doi:10.1016/j.clineuro.2004.12.005

Cited by 54 publications

(29 citation statements)

References 26 publications

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“…Atrophy in the limbic and paralimbic regions occurs in patients with PD without dementia, though less markedly so than in patients with PDD. 29,30 Metabolic abnormalities in the posterior cingulate regions 31,32 and cerebral blood flow reduction in the anterior cingulate cortex 33,34 have been reported in patients with PDD. A reduction in cerebral blood flow in the posterior cingulate cortex has also been reported in PDD.…”

Section: Discussionmentioning

confidence: 99%

“…A reduction in cerebral blood flow in the posterior cingulate cortex has also been reported in PDD. 33 In several previous studies of neuropsychologic diseases such as amyotrophic lateral sclerosis, posttraumatic stress disorder, and schizophrenia, metabolic and cerebral blood flow abnormalities in the cortex and diffusion abnormalities in the white matter tracts that connect the affected regions of the cortex have been reported. 16,35,36 Our definition of the posterior cingulum bundle probably corresponds to the white matter directly below the posterior cingulate cortex and dorsal middle cingulate cortex, as described by Vogt et al 15 They have also reported on the relationship between the posterior cingulate cortex and visuospatial perception.…”

Section: Discussionmentioning

confidence: 99%

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White Matter Alteration of the Cingulum in Parkinson Disease with and without Dementia: Evaluation by Diffusion Tensor Tract–Specific Analysis

Kamagata¹,

Motoi²,

Abe³

et al. 2012

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

White Matter Alteration of the Cingulum in Parkinson Disease with and without Dementia: Evaluation by Diffusion Tensor Tract–Specific Analysis

Kamagata¹,

Motoi²,

Abe³

et al. 2012

AJNR Am J Neuroradiol

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“…To index disease, functional deficits on neuropsychological tests should correlate with regional dysfunction on neuroimaging . SPECT has been widely used to identify regional cerebral perfusion deficits indicating the presence of AD and other dementias (Bonte et al, 2004;Mito et al, 2005) because it is relatively inexpensive and more widely available compared with PET, though it has lower sensitivity and spatial resolution (Bartenstein et al, 1997;Desgranges et al, 1998;Elgh et al, 2002;Lampl et al, 2003;Meguro et al, 2001;Yamaguchi et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Regional cerebral blood flow correlates of visuospatial tasks in Alzheimer's disease

Tippett

Black

2008

J Int Neuropsychol Soc

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This study investigated the role of visuospatial tasks in identifying cognitive decline in patients with Alzheimer's disease (AD), by correlating neuropsychological performance with cerebral perfusion measures. There were 157 participants: 29 neurologically healthy controls (age: 70.3 6 6.6, MMSE Ն 27), 86 patients with mild AD (age: 69.18 6 8.28, MMSE Ն 21) and 42 patients moderate0severe AD (age: 68.86 6 10.69, MMSE 8-20). Single Photon Emission Computerized Tomography (SPECT) was used to derive regional perfusion ratios, and correlated using partial least squares (PLS) with neuropsychological test scores from the Benton Line Orientation (BLO) and the Rey-Osterrieth Complex Figure (RO). Cross-sectional analysis demonstrated that mean scores differed in accordance with disease status: control group (BLO 25.5, RO 33.3); mild AD (BLO 20.1, RO 25.5); moderate0severe AD (BLO 10.7, RO 16). Correlations were observed between BLO0RO and right parietal SPECT regions in the AD groups. Visuospatial performance, often undersampled in cognitive batteries for AD, is clearly impaired even in mild AD and correlates with functional deficits as indexed by cerebral perfusion ratios on SPECT implicating right hemisphere circuits. Furthermore, PLS reveals that usual spatial tasks probe a distributed brain network in both hemispheres including many areas targeted by early AD pathology. (JINS, 2008(JINS, , 14, 1034(JINS, -1045

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“…The decreased FA of the posterior CB in the PDD group may be associated with the pathologic process responsible for dementia in PD. Metabolic abnormalities in the posterior cingulate regions 40,41 and cerebral blood ‰ow reduction in the posterior cingulate cortex 42 have been reported in patients with PDD. Therefore, FA abnormalities in the posterior CB may re‰ect microstructural changes underlying the particular pathophysiology of PDD.…”

Section: Discussionmentioning

confidence: 99%

Automatic Extraction of the Cingulum Bundle in Diffusion Tensor Tract-specific Analysis: Feasibility Study in Parkinson's Disease with and without Dementia

et al. 2013

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Purpose: Tract-speciˆc analysis (TSA) measures diŠusion parameters along a speciˆĉ ber that has been extracted byˆber tracking using manual regions of interest (ROIs), but TSA is limited by its requirement for manual operation, poor reproducibility, and high time consumption. We aimed to develop a fully automated extraction method for the cingulum bundle (CB) and to apply the method to TSA in neurobehavioral disorders such as Parkinson's disease (PD).Materials and Methods: We introduce the voxel classiˆcation (VC) and auto diŠusion tensorˆber-tracking (AFT) methods of extraction. The VC method directly extracts the CB, skipping theˆber-tracking step, whereas the AFT method usesˆber tracking from automatically selected ROIs. We compared the results of VC and AFT to those obtained by manual diŠusion tensorˆber tracking (MFT) performed by 3 operators. We quantiˆed the Jaccard similarity index among the 3 methods in data from 20 subjects (10 normal controls [NC] and 10 patients with Parkinson's disease dementia [PDD]). We used all 3 extraction methods (VC, AFT, and MFT) to calculate the fractional anisotropy (FA) values of the anterior and posterior CB for 15 NC subjects, 15 with PD, and 15 with PDD.Results: The Jaccard index between results of AFT and MFT, 0.72, was similar to the inter-operator Jaccard index of MFT. However, the Jaccard indices between VC and MFT and between VC and AFT were lower. Consequently, the VC method classiˆed among 3 diŠerent groups (NC, PD, and PDD), whereas the others classiˆed only 2 diŠerent groups (NC, PD or PDD).Conclusion: For TSA in Parkinson's disease, the VC method can be more useful than the AFT and MFT methods for extracting the CB. In addition, the results of patient data analysis suggest that a reduction of FA in the posterior CB may represent a useful biological index for monitoring PD and PDD.

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Brain 3D-SSP SPECT analysis in dementia with Lewy bodies, Parkinson's disease with and without dementia, and Alzheimer's disease

Cited by 54 publications

References 26 publications

White Matter Alteration of the Cingulum in Parkinson Disease with and without Dementia: Evaluation by Diffusion Tensor Tract–Specific Analysis

White Matter Alteration of the Cingulum in Parkinson Disease with and without Dementia: Evaluation by Diffusion Tensor Tract–Specific Analysis

Regional cerebral blood flow correlates of visuospatial tasks in Alzheimer's disease

Automatic Extraction of the Cingulum Bundle in Diffusion Tensor Tract-specific Analysis: Feasibility Study in Parkinson's Disease with and without Dementia

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