Brain abscess associated with Mycoplasma faucium – The initial presentation of pulmonary arteriovenous malformation

Rothman, Ryan; Saini, Vikram; Min, Zaw; Bhanot, Nitin

doi:10.1016/j.idcr.2022.e01575

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…Non-fermentative Mycoplasmas such as M. faucium , which produce ammonia from arginine can cause tissue damage and neutralize gastric acid ( Kwon et al., 2004 ). Furthermore, M. faucium has been associated with brain abscess in a non-immunocompromised patients ( Al Masalma et al., 2009 ; Rothman et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

The complete genome sequence of unculturable Mycoplasma faucium obtained through clinical metagenomic next-generation sequencing

Sabat,

Durfee,

Baldwin

et al. 2024

Front. Cell. Infect. Microbiol.

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IntroductionDiagnosing Mycoplasma faucium poses challenges, and it's unclear if its rare isolation is due to infrequent occurrence or its fastidious nutritional requirements.MethodsThis study analyzes the complete genome sequence of M. faucium, obtained directly from the pus of a sternum infection in a lung transplant patient using metagenomic sequencing.ResultsGenome analysis revealed limited therapeutic options for the M. faucium infection, primarily susceptibility to tetracyclines. Three classes of mobile genetic elements were identified: two new insertion sequences, a new prophage (phiUMCG-1), and a species-specific variant of a mycoplasma integrative and conjugative element (MICE). Additionally, a Type I Restriction-Modification system was identified, featuring 5’-terminally truncated hsdS pseudogenes with overlapping repeats, indicating the potential for forming alternative hsdS variants through recombination.ConclusionThis study represents the first-ever acquisition of a complete circularized bacterial genome directly from a patient sample obtained from invasive infection of a primary sterile site using culture-independent, PCR-free clinical metagenomics.

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Section: Introductionmentioning

confidence: 99%

The complete genome sequence of unculturable Mycoplasma faucium obtained through clinical metagenomic next-generation sequencing

Sabat,

Durfee,

Baldwin

et al. 2024

Front. Cell. Infect. Microbiol.

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Mycoplasma

Balish,

Chopra‐Dewasthaly,

Pereyre

et al. 2024

Bergey's Manual of Systematics of Archaea and Bacteria

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My.co.plas'ma. Gr. masc. n. mykês , mushroom or other fungus; Gr. neut. n. plasma , anything formed or molded, image, figure; N.L. neut. n. Mycoplasma , fungus form. Bacillota_I / Bacilli_A / Mycoplasmatales / Mycoplasmataceae / Mycoplasma Bacteria in the genus Mycoplasma are small (300–800 nm in diameter) pleomorphic cells devoid of a cell wall. Culturable species usually form very small (<1 mm) umbonate colonies on agar. Their use of the codon UGA to encode tryptophan is a distinctive characteristic of all species examined to date. As a consequence of their small (usually 0.5–1.5 Mb) genomes they have limited intermediary metabolism and are nutritionally fastidious, requiring exogenous carbohydrates or arginine, fatty acids, cholesterol or other sterols, peptides, cofactors, and free nucleic acids for axenic growth. In nature, all species are obligate commensals or parasites with varying degrees of specificity for a wide range of vertebrate hosts. The type species Mycoplasma mycoides subsp. mycoides and Mycoplasma capricolum subsp. capripneumoniae are highly virulent animal pathogens subject to strict international regulations, but the genus is perhaps better known for Mycoplasma pneumoniae , the agent of primary atypical “walking” pneumonia in humans. The relative biological simplicity of mycoplasmas confers significant advantages for current proteomics, metabolomics, synthetic genomics, and systems biology research. For example, the recent chemical synthesis and transplantation of intact chromosomes demonstrated that it is possible to enliven a mycoplasma fully capable of autonomous replication with an artificially constructed genome. DNA G + C content (mol%) : 23–40. Type species : Mycoplasma mycoides Freundt 1955 AL (basonym: Asterococcus mycoides Borrel et al. 1910.

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Brain abscess associated with Mycoplasma faucium – The initial presentation of pulmonary arteriovenous malformation

Cited by 2 publications

References 13 publications

The complete genome sequence of unculturable Mycoplasma faucium obtained through clinical metagenomic next-generation sequencing

The complete genome sequence of unculturable Mycoplasma faucium obtained through clinical metagenomic next-generation sequencing

Mycoplasma

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