Brain abscess in 142 patients: factors influencing outcome and mortality

Tseng, Jen-Ho; Tseng, Ming-Yuan

doi:10.1016/j.surneu.2005.09.029

Cited by 168 publications

(167 citation statements)

References 19 publications

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“…Abscesses of unknown cause accounted for 54.94% of the subjects, higher than the values reported for other series. [12,39,[41][42][43] In most large series of brain abscesses from developing countries, middle ear infection has been reported to be the most common source of intracranial suppuration, a result similar to the current study. [44] The basic principle of treatment is the prescription of appropriate antibiotics with or without aspiration, treatment of sequelae that is, hydrocephalus, seizures etc., and eradication of primary source.…”

Section: Discussionsupporting

confidence: 90%

“…[4] The common predisposing factors of a brain abscess are CSOM, congenital cyanotic heart disease, and paranasal sinusitis. [1,5,[10][11][12] Immunosuppression due to disease or therapy is emerging as an important risk factor for the development of brain abscess. [4] Here, we found predisposing factors of brain abscesses were similar.…”

Section: Discussionmentioning

confidence: 99%

“…[26] According to a number of authors, treatment of brain abscess involves aspiration of the pus or excision of the abscess, followed by parenteral antibiotic therapy. [1,5,6,12,45] Empirical medical therapy is the best avoided and should be reserved for patients in whom a bacteriological diagnosis has been obtained from a systemic source or who are extremely ill that is, too ill to undergo any forms of intervention. [45] Small abscesses and lesions in the cerebritis stage respond well to medical therapy alone.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Brain abscess: surgical experiences of 162 cases

Chowdhury¹,

Haque²,

Sarkar³

et al. 2015

Neuroimmunol Neuroinflammation

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Brain abscess: surgical experiences of 162 cases

Chowdhury¹,

Haque²,

Sarkar³

et al. 2015

Neuroimmunol Neuroinflammation

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“…Operative drainage of abscesses >2.5 cm in diameter and antibiotic therapy resulted in a mortality rate of 13%, a poor outcome in 5%, and a good outcome in 81% of patients [84]. These outcomes are similar in other retrospective studies in Europe and Asia [6,85,86].…”

Section: Bacterial Brain Abscesssupporting

confidence: 77%

Neuro-Intensive Care of Patients with Acute CNS Infections

Beckham

Tyler

2012

Neurotherapeutics

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Summary Infections in the central nervous system (CNS) are caused by a wide range of microorganisms resulting in distinct clinical syndromes including meningitis, encephalitis, and pyogenic infections, such as empyema and brain abscess. Bacterial and viral infections in the CNS can be rapidly fatal and can result in severe disability in survivors. Appropriate identification and acute management of these infections often occurs in a critical care setting and is vital to improving outcomes in this group of patients. This review of diagnosis and management of acute bacterial and viral infections in the CNS provides a general approach to patients with a suspected CNS infection and also provides a more detailed review of the diagnosis and management of patients with suspected bacterial meningitis, viral encephalitis, brain abscess, and subdural empyema.

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“…1) The percentage of cryptogenic cases is around 25-38%. 7,15) Staphylococcus is by far the commonest organism cultured (63%) followed by streptococci (20%). 1) The location and predisposing condition of the abscess provide clues to the possible cause.…”

Section: Discussionmentioning

confidence: 99%

Aspiration Versus Excision: A Single Center Experience of Forty-Seven Patients With Brain Abscess Over 10 Years

Sarmast

Showkat

Kirmani

et al. 2012

Neurol. Med. Chir.(Tokyo)

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The efficacies of two different surgical approaches, aspiration and excision, were investigated for the management of large solitary encapsulated pyogenic brain abscess located in superficial non-eloquent areas, and the impact on length of hospital stay, duration of postoperative antibiotic use, improvement in neurological status, and morbidity and mortality were compared. This retrospective study at Sher-iKashmir Institute of Medical Sciences included 47 patients with pyogenic brain abscess from a total of 114 patients evaluated in the Department of Neurosurgery over a period of 10 years from October 2001 to October 2011. Comparisons were made between aspiration and excision in terms of duration of antibiotic use, length of hospital stay, and overall treatment cost. Aspiration was performed in 29 patients (61.7%), of whom 7 patients needed second aspiration, and 18 patients underwent excision (38.3%) of the abscess capsule. The mean duration of antibiotic use in the excision group was significantly shorter at 2.7 weeks (standard deviation [SD] ± 1.1) compared to the aspiration group at 3.8 weeks (SD ± 1.3) (p ＝ 0.006). Similarly, mean length of hospital stay was significantly shorter in the excision group at 18.1 days (SD ± 7.7) compared to the aspiration group at 24.9 days (SD ± 6.6) (p ＝ 0.002). In addition, significantly earlier improvement in neurological function (p ＝ 0.025) and significantly lower rate of re-surgery (p ＝ 0.0238) were found in the excision group compared to the aspiration group. Excision is better than aspiration as far as duration of antibiotic use, length of hospital stay, and overall cost of treatment is concerned, with no significant difference in morbidity and mortality.

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Brain abscess in 142 patients: factors influencing outcome and mortality

Cited by 168 publications

References 19 publications

Brain abscess: surgical experiences of 162 cases

Brain abscess: surgical experiences of 162 cases

Neuro-Intensive Care of Patients with Acute CNS Infections

Aspiration Versus Excision: A Single Center Experience of Forty-Seven Patients With Brain Abscess Over 10 Years

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