Brain abscesses caused by anaerobic bacteria

Cobo, Fernando; Martín-Hita, Lina; Navarro-Marí, José María

doi:10.1016/j.anaerobe.2022.102614

Cited by 9 publications

(16 citation statements)

References 14 publications

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“…A total of 391 from 6,167 patients (6.3%) with brain abscesses died (ranging to 0% to 32%). brain abscess that suffered a previous neurosurgery procedure [12]. Another study recently published also showed C. acnes as the second most frequent isolate in that series, although the authors cannot establish any relationship with a possible source of infection [10].…”

Section: Sources Of Information and Selection Of Studiesmentioning

confidence: 84%

“…Overall, data on brain abscesses caused specifically by anaerobic bacteria are currently limited. Searching the medical literature, only 7 studies described in detail the characteristics of brain abscesses caused by anaerobes [4,[7][8][9][10][11][12]. Taken into account the 28 studies focused on brain abscesses included in this review, the presence of anaerobes in these infections occurs in 11.5% on average (715 patients from 6,167).…”

Section: Discussionmentioning

confidence: 99%

“…There were 70% men (data not reported in 3 studies) and the mean age of patients was 40.3 years (data not reported in 5 studies). The cases were distributed as follows: 9 from India [4,8,9,11,[13][14][15][16][17], 4 from Taiwan [18][19][20][21], 3 from Spain [12,22,23], 3 from France [7,24,25], 2 from UK [26,27], and one each from USA [28], Italy [29], Finland [30], Hungary [10], South Africa [31], Denmark [3] and Pakistan [32].…”

Section: General Characteristicsmentioning

confidence: 99%

“…All cultures were performed from samples obtained by different surgical techniques such as aspiration/drainage and excision. Detailed microbiological methods related to the culture procedure and the identification of pathogens were only reported in 14 (50%) studies [4,7,[8][9][10][11][12][13][14][15]18,21,22,28], and there were so many differences in the microbiological methodologies used. Overall results of the cultures yielded a total of 546 anaerobic bacteria isolated from the brain abscesses.…”

Section: Sources Of Information and Selection Of Studiesmentioning

confidence: 99%

“…These microorganisms are not well routinely isolated in the majority of laboratories due to the difficulties in the isolation procedures. This circumstance has contributed to the fact that few studies are focused on brain abscesses caused only by anaerobic pathogens [4,[7][8][9][10][11][12]. Thus, the literature has provided only limited guidance with respect to the patients diagnosed with this condition, so the main objective of this study was to review the scientific literature containing cases of brain abscesses caused by anaerobic bacteria.…”

Section: Introductionmentioning

confidence: 99%

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Brain abscesses caused by anaerobic microorganisms: a systematic review

Cobo¹

2023

Rev Esp Quimioter

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The objective of this study was to perform a systematic review of the characteristics, causative microorganisms and outcome of brain abscesses caused by anaerobic bacteria over the past 25 years. We reviewed studies on brain abscesses which included infection due to anaerobic microorganisms published between 1998 and 2022. We excluded reports with polymicrobial infections (more than 2 anaerobic bacteria isolated) and those that do not provide enough information to make comparisons, the reports with only one case of brain abscess due to anaerobes, as well as those focused on an only anaerobic bacterium. Also, we have excluded the cases in pediatric population. We searched the scientific literature through the Cochrane Library, EMBASE and PubMed/MEDLINE databases for studies of this condition. We finally included 28 studies with 6,167 patients, of which 715 (11.5%) were cases caused by anaerobic bacteria. There was a male predominance (70%) and mean age of 40.3 years. Most infections were monomicrobial (59.4%). The most common anaerobic microorganisms isolated were Bacteroides spp (43.4%) and Gram-positive anaerobic cocci (35.1%). Cases of brain abscesses caused by anaerobic bacteria were most frequent in Asia and Europe. The source of infection most frequent was otogenic in 84.6% followed by a neurosurgery procedure infection in 23% of patients. The main symptom observed was headache in 95.6% of patients followed by fever (69.5%). Surgical treatment was performed in 48 % of patients and the percentage of patients in whom antibiotic treatment was applied range 88.8% to 100%. The main limitation of this review is the non-inclusion of studies published before of 1998 in which MALDI-TOF MS system had not been introduced in the majority of laboratories for routine identification. The patient rate with isolation of anaerobic bacteria in brain abscesses is low, but these data could be underestimated mainly due to the fastidious nature of these microorganisms and the difficulties in the identification of some anaerobes.

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Section: Sources Of Information and Selection Of Studiesmentioning

confidence: 84%