2002
DOI: 10.1523/jneurosci.22-03-01072.2002
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Brain and Body Hyperthermia Associated with Heroin Self-Administration in Rats

Abstract: Intravenous heroin self-administration in trained rats was accompanied by robust brain hyperthermia (ϩ2.0-2.5°C); parallel changes were found in the dorsal and ventral striatum, mediodorsal thalamus, and deep temporal muscle. Temperature began to increase at variable latency after a signal of drug availability, increased reliably (ϳ0.4°C) before the first lever press for heroin, increased further (ϳ1.2°C) after the first heroin injection, and rose more slowly after the second and third injections to stabilize … Show more

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Cited by 33 publications
(20 citation statements)
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“…The differences between conditions involve varied neurosystems and are likely linked to interactions with motivational state sets and conditioned compensatory responses (Weise-Kelly and Siegel, 2001; Kiyatkin and Wise, 2002; Kuntz et al, 2008; LaLumiere and Kalivas, 2008; Weber et al, 2009). We utilized the yoked-control paradigm in order to eliminate from consideration any genes merely altered by the surgical (yoked-saline) and experimental procedures (yoked-morphine) and those unrelated to intentional drug-taking behavior (yoker vs yoked-morphine and yoked-saline).…”
Section: Discussionmentioning
confidence: 99%
“…The differences between conditions involve varied neurosystems and are likely linked to interactions with motivational state sets and conditioned compensatory responses (Weise-Kelly and Siegel, 2001; Kiyatkin and Wise, 2002; Kuntz et al, 2008; LaLumiere and Kalivas, 2008; Weber et al, 2009). We utilized the yoked-control paradigm in order to eliminate from consideration any genes merely altered by the surgical (yoked-saline) and experimental procedures (yoked-morphine) and those unrelated to intentional drug-taking behavior (yoker vs yoked-morphine and yoked-saline).…”
Section: Discussionmentioning
confidence: 99%
“…While heroin in rats is self-administered within a wide range of doses (0.025–0.2 mg/kg), a 0.1 mg/kg dose appears to be optimal for maintaining consistent behavioral performance with stable inter-injection intervals (Gerber and Wise, 1989). This dose is much lower than the estimated LD50 for iv administration in rats (15–20 mg/kg; Jackson, 1952; Strandberg et al, 2006; Gable, 2004) and heroin at this dose is self-administered by rats during multiple sessions without any significant health complications (Bozarth and Wise, 1985; Kiyatkin et al, 1993; Kiyatkin and Wise, 2002). This dose is also close to typical human doses in terms of drug amount per body weight (5–10 mg/70 kg; Goldstein, 1994; see also www.erowid.org).…”
Section: Introductionmentioning
confidence: 85%
“…Although these mechanisms could be viewed as non-specific, it does not mean that they are not important or that they should be ignored. While these issues are not within the goals of this review article, brain thermorecording has been used previously to study sexual behavior (22, 92), feeding behavior (20) as well as heroin (93) and cocaine self-administration behavior (94). …”
Section: Brain Temperature As a Factor Affecting Neural Activity Amentioning
confidence: 99%