Brain‐derived neurotrophic factor ameliorates lipid metabolism in diabetic mice

Tsuchida, Atsushi; Nonomura, Takeshi; Nakagawa, Tsutomu; Itakura, Yasushi; Ono-Kishino, Michiko; Yamanaka, Mitsugu; Sugaru, Eiji; Taiji, Mutsuo; Noguchi, Hiroshi

doi:10.1046/j.1463-1326.2002.00206.x

Cited by 89 publications

(64 citation statements)

References 34 publications

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“…BDNF increases fat oxidation in an AMPK-dependent manner in L6 myotubes Having established that BDNF was a contraction-induced protein, we next sought to determine whether BDNF affected signalling pathways associated with fat oxidation in skeletal muscle. This hypothesis was based on the observation that BDNF reduces obesity in diabetic mice [18]. AMPK phosphorylates ACCβ resulting in inhibition of ACC activity, which in turn leads to a decrease in malonyl-CoA content, relieving inhibition of carnitine palmitoyl transferase 1 and increasing fatty acid oxidation (FAO).…”

Section: Resultsmentioning

confidence: 99%

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Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

Matthews¹,

Åström

Chan³

et al. 2009

Diabetologia

572

480

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Aims/hypothesis Brain-derived neurotrophic factor (BDNF) is produced in skeletal muscle, but its functional significance is unknown. We aimed to determine the signalling processes and metabolic actions of BDNF. Methods We first examined whether exercise induced BDNF expression in humans. Next, C2C12 skeletal muscle cells were electrically stimulated to mimic contraction. L6 myotubes and isolated rat extensor digitorum longus muscles were treated with BDNF and phosphorylation of the proteins AMP-activated protein kinase (AMPK) (Thr 172 ) and acetyl coenzyme A carboxylase β (ACCβ) (Ser 79 ) were analysed, as was fatty acid oxidation (FAO).Finally, we electroporated a Bdnf vector into the tibialis cranialis muscle of mice. Results BDNF mRNA and protein expression were increased in human skeletal muscle after exercise, but muscle-derived BDNF appeared not to be released into the circulation. Bdnf mRNA and protein expression was increased in muscle cells that were electrically stimulated. BDNF increased phosphorylation of AMPK and ACCβ and enhanced FAO both in vitro and ex vivo. The effect of BDNF on FAO was AMPK-dependent, since the increase in FAO was abrogated in cells infected with an AMPK dominant negative adenovirus or treated with Compound C, an inhibitor of AMPK. Electroporation of a Bdnf expression

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Section: Resultsmentioning

confidence: 99%

“…It is also known that BDNF reduces food intake and lowers blood glucose in genetically modified (db/db) obese mice [15][16][17][18]. It is clear, therefore, that BDNF plays a role in both neurobiology and metabolism.…”

Section: Introductionmentioning

confidence: 99%

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

Matthews¹,

Åström

Chan³

et al. 2009

Diabetologia

572

480

View full text Add to dashboard Cite

show abstract

“…In addition to its neurotrophic and synaptotrophic actions, including the promotion of growth and survival in neurons, 7,8 BDNF plays a role in learning and memory, 9 the regulation of food intake, 10 glucose and lipid metabolism and energy homeostasis. 11,12 BDNF is present in the nervous system and peripheral tissues and is also found in blood. [13][14][15] Accumulating evidence shows the serum BDNF levels to be associated with psychiatric and metabolic disorders, including depression, 16,17 Alzheimer disease, 18 and diabetes mellitus.…”

mentioning

confidence: 99%

Serum Brain-Derived Neurotrophic Factor Levels Are Associated with Dyssomnia in Females, but not Males, among Japanese Workers

Nishichi

Nufuji

Washio

et al. 2013

Journal of Clinical Sleep Medicine

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Study Objectives: Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that promote the growth and survival of neurons. Recent evidence suggests that BDNF is a sleep regulatory substance that contributes to sleep behavior. However, no studies have examined the association between the serum BDNF levels and dyssomnia. The present study was conducted to clarify the association between the serum BDNF levels and dyssomnia. Methods: A total of 344 workers (age: 40.1 ± 10.5 years, male: 204, female: 140) were included in the study. The serum BDNF levels were categorized into tertiles according to sex. Results: The prevalence of dyssomnia was 35.1% in males and 30.0% in females. In the females, the BDNF levels were found to be negatively associated with dyssomnia after adjusting for age, body mass index, hypertension, dyslipidemia, hyperglycemia, depression, smoking, alcohol intake, and regular exercise. Compared with the females in the high BDNF group, the multivariate odds ratio (95% CI) of dyssomnia was 2.08 (0.62-6.98) in females in the moderate BDNF group and 8.41 (2.05-27.14) in females in the low BDNF group. No such relationships were found in the males. Conclusions: The serum BDNF levels are associated with dyssomnia in Japanese female, but not male, workers. keywords: Serum brain-derived neurotrophic factor, dyssomnia, sex, Japanese worker Citation: Nishichi R; Nufuji Y; Washio M; Shuzo Kumagai S. Serum brain-derived neurotrophic factor levels are associated with dyssomnia in females, but not males, among Japanese workers. J Clin Sleep Med 2013;9(7):649-654.

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“…Circulating BDNF was reported to correlate positively to LDL cholesterol, total cholesterol and triglyceride levels in humans (16,17). In animal experiments, BDNF treatment reported to lower blood glucose, non-esterified free fatty acid, total cholesterol and phospholipid levels significantly in diabetic models, along with liver weight, liver triglyceride contents and fatty liver in histological examinations (28). Furthermore, administration of simvastatin elevated the expression of BDNF in the brain and accelerated the neuronal and functional recovery (29).…”

Section: Bdnf Blood Level and Its Associatesmentioning

confidence: 99%

Brain derived neurotrophic factor (BDNF) in cardiometabolic physiology and diseases

Taşçı¹,

Kabul²,

Aydoğdu³

2012

Anadolu Kardiyol Derg

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Important advances in our understanding of the relationships between adipose tissue derived peptides, namely adipokines, and their effects on cardiovascular functions have been achieved in recent years. Growing knowledge of adipokine biology is revealing the complexity of these proteins. Adipose tissue releases some other proteins called neurotrophins that are mainly active in central and peripheral nervous system. However, secretion and activity of these hormones are not only limited to neuronal cells and tissues, but they also take part in adipose tissue development, energy metabolism, glucose utilization, insulin sensitivity, inflammation, lipoprotein synthesis, and atherosclerosis. In this review, we describe the most recent advances in the functions of brain derived nerve growth factor (BDNF), a major type of neurotrophins, focusing primarily on cardiovascular and metabolic diseases. (Anadolu Kardiyol Derg 2012; 12: 684-8) Key words: Brain derived nerve growth factor, cardiovascular disease, atherosclerosis, dyslipidemia, diabetes mellitus Review Derleme 684ÖZET Son yıllarda, adipokinler olarak bilinen adipoz doku kaynaklı peptidler ve bunların kardiyovasküler fonksiyonlar üzerine etkileri üzerine önemli ilerlemeler sağlanmıştır. Adipokin biyolojisi hakkında bilgiler çoğaldıkça bu proteinlerin karmaşık görünümü aydınlatılmaktadır. Adipoz doku nörotrofin-ler olarak bilinen ve temel olarak santral ve periferal sinir sisteminde görev yapan diğer bazı proteinleri de salgılar. Bununla beraber, bu hormonların sekresyon ve aktivitesi sadece nöronal hücreler ve dokularla sınırlı olmayıp yağ dokusu gelişimi, enerji metabolizması, glikoz kullanımı, insülin duyarlılığı, enflamasyon, lipoprotein sentezi ve aterosklerozda da rol oynarlar. Bu derlemede majör bir nörotrofin olan beyinden türemiş nörotrofik faktör (BDNF) ile ilgili en son veriler, özellikle kardiyovasküler ve metabolik hastalıklar üzerinden irdelenmiştir.

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Brain‐derived neurotrophic factor ameliorates lipid metabolism in diabetic mice

Abstract: Taken together with the accelerating effect of BDNF on energy metabolism, these findings indicate that BDNF improves glucose and lipid metabolism in obese diabetic animals without enlarging liver or adipose tissues.

Cited by 89 publications

References 34 publications

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

Serum Brain-Derived Neurotrophic Factor Levels Are Associated with Dyssomnia in Females, but not Males, among Japanese Workers

Brain derived neurotrophic factor (BDNF) in cardiometabolic physiology and diseases

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