Brain Derived Neurotrophic Factor as a Non-invasive Biomarker for  Detection of Endometriosis

Dwiningsih, Sri Ratna; Meilani, Christina; Hadi, Samsul

doi:10.18502/jri.v23i3.10012

Cited by 5 publications

(7 citation statements)

References 27 publications

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“…Wessels et al compared BDNF levels in patients who received treatment for endometriosis with patients who did not, the results showed a significantly decreased BDNF level in the treated group [ 6 ]. Although BDNF was significantly higher in endometriosis compared with healthy controls, no significant changes were reported between different stages of endometriosis [ 6 , 11 ]. However, BDNF expression in eutopic endometrium is positively correlated with stages of endometriosis [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Elevated levels of BDNF have been reported in the peritoneal fluid, serum, and endometrial tissue of women with endometriosis compared to healthy controls [ 8 – 10 ]. These findings suggest that BDNF may be involved in the pathogenesis of endometriosis and could potentially serve as a diagnostic or prognostic marker [ 7 , 11 ]. However, the existing literature on the association between BDNF and endometriosis is still limited and characterized by inconsistencies in findings.…”

Section: Introductionmentioning

confidence: 99%

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Brain-derived neurotrophic factor (BDNF) as a potential marker of endometriosis: a systematic review and meta-analysis

Jafarabady,

Shafiee,

Bahri

et al. 2024

BMC Women's Health

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Background The existing literature on the association between BDNF protein levels and endometriosis presents inconsistent findings. This systematic review and meta-analysis aim to synthesize the available evidence and evaluate the possible relationship between BDNF protein levels and endometriosis. Methods Electronic databases (PubMed, Embase, Scopus, PsycINFO, and Web of Science) were used to conduct a comprehensive literature search from inception to June 2023. The search strategy included relevant keywords and medical subject headings (MeSH) terms related to BDNF, endometriosis, and protein levels. A random-effects model was used for the meta-analysis, and to explore heterogeneity subgroup analyses were performed. funnel plots and statistical tests were used for assessing the publication bias. Results A total of 12 studies were included. The pooled standardized mean difference (SMD) of BDNF levels between women with endometriosis and controls was 0.87 (95% confidence interval [CI] 0.34 to 1.39, p = 0.001; I2 = 93%). The results showed that blood levels of BDNF are significantly higher in endometriosis patients (SMD: 1.13 95% CI 0.54 to 1.73, p = 0.0002; I2 = 93%). No significant publication bias was observed based on the results of Egger’s regression test ((p = 0.15). Conclusion This study revealed a significant difference between patients diagnosed with endometriosis and healthy control in the level of BDNF. The results indicate that women with endometriosis have higher levels of BDNF. Further studies are needed to be undertaken to investigate the role of BDNF in endometriosis pathophysiology and the diagnostic value of BDNF in endometriosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Brain-derived neurotrophic factor (BDNF) as a potential marker of endometriosis: a systematic review and meta-analysis

Jafarabady,

Shafiee,

Bahri

et al. 2024

BMC Women's Health

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“…Recently, Dwiningsih S [19] demonstrate how BNF has higher levels in women with endometriosis than those without the disease and finds an association with the degree of pain. However, it does not analyze the response to treatment, one of the key points to provide an optimal marker.…”

Section: Discussionmentioning

confidence: 99%

Brain Derived Neurotrophin Factor (BDNF) as a clinical marker of endometriosis

Manero,

Goyenechea

2023

Open J Clin Med Case Rep

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Background: Endometriosis is a chronic, multifactorial disease of unknown etiology that affects approximately 10% of all women of childbearing age. It is characterized by dysmenorrhea and chronic pelvic pain, often associated with other symptoms (dyspareunia, dyschezia, rectal bleeding, dysuria, among others) and in 30-40% of cases it is associated with infertility. The presence of pelvic pain is related to the process of neuroangiogenesis, with the presence of BDNF being a key piece in its development. Several recent studies have shown that BDNF levels are elevated in the serum of patients with endometriosis compared to patients without endometriosis. The objective of this study is to demonstrate if BDNF levels are higher in patients with endometriosis and if there is am correlation with the level of pain. Material and methods: The study included 59 patients diagnosed with ovarian endometriosis in the Gynecology service of the Garcia Orcoyen Hospital during the period from November 2021 to August 2022. A blood sample was taken before surgery and their BDNF blood levels were determined. The levels of BDNF were analyzed compared to the control group in 10 patients undergoing laparoscopic tubal ligation to establish if the levels were higher in the endometriosis group and if there was a correlation with the intensity of pain.

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“…За даними останніх досліджень, виявлено підвищення концентрації BDNF у сироватці та плазмі крові у жінок з ендометріозом, асоційованим із тазовим болем і безпліддям, порівняно з контрольними групами [7,[13][14][15]18]. Рівень BDNF у крові пацієнток з ендометріозом позитивно корелює з клінічною стадією ендометріозу, тяжкістю СХТБ та ступенем дисменореї [7,17,19].…”

Section: г і н е к о л о г і яunclassified

“…Рівень BDNF у крові пацієнток з ендометріозом позитивно корелює з клінічною стадією ендометріозу, тяжкістю СХТБ та ступенем дисменореї [7,17,19]. Також рівні BDNF у плазмі крові позитивно корелюють із показниками рівня тяжкості болю [14,18,19]. Окрім цього, виявлено зниження рівня BDNF після хірургічного та консервативного лікування [14,15,20].…”

Section: г і н е к о л о г і яunclassified

Actualization of differential diagnosis of chronic pelvic pain syndrome in women of reproductive age

Solomko

Shurpyak

2023

RHW

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The objective: to study the significance of the levels of tumor necrosis factor α (TNF-α) and brain-derived neurotrophic factor (BDNF) in the blood of patients with chronic pelvic pain syndrome (CPPS).Materials and methods. The examined cohort included 150 patients with CPPS, who according to the clinical manifestations were divided into groups A and B: group A (n=74) included the patients with CPPS and suspicion of endometriosis and group B (n=76) – patients with CPPS and suspicion for benign proliferative diseases of reproductive organs. The control group included healthy women (n=50).Serum TNF-α and plasma BDNF levels were investigated by enzyme-linked immunosorbent assay. A visual analog scale (VAS) was used to study pain intensity.Results. The mean concentration of TNF-α in blood serum was significantly higher in women of group A (10.76±0.55 pg/ml) and group B (14.65±0.95 pg/ml) than in the control one (5.02±0.31 pg/ml). The mean concentration of BDNF in blood plasma was higher in women in group A (1473.88±53.02 pg/ml; p<0.001) and in group B (1711.65±66.79 pg/ml; p<0.01) compared to the control group (1082.91±56.24 pg/ml). The levels of TNF-α (p<0.001) and BDNF (p<0.01) are significantly higher in the blood of patients with CPPS and suspected combined benign proliferative diseases of the reproductive organs (group B) than in patients with CPPS and suspected endometriosis (group A).Between the intensity of pain according to VAS and the level of TNF-α in the blood a direct correlation of medium strength was found (r=0.56) in patients of group A and group B (r=0.62). A strong direct correlation between the intensity of pain according to VAS and the level of BDNF in the blood was established in women of group A (r=0.74) and group B (r=0.83).Between the disease duration and the level of TNF-α in the blood of patients a direct correlation of medium strength (r=0.65) in group A and a direct strong correlation (r=0.72) in group B were determined. Between the duration of the disease and the level of BDNF in the blood of patients a direct correlation of average strength was also establishe, a strong correlation (r=0.67) was determined in group A and a direct strong correlation (r=0.78) – group B.Conclusions. Women with CPPS and suspicion of benign proliferative diseases of the organs of the reproductive system have significantly higher concentrations of TNF-α and BDNF in the blood compared to healthy women (p<0.001).The existence of a direct correlation between the intensity of pain, the duration of the disease, and the levels of TNF-α and BDNF suggest the possibility of their use as objective markers of the effectiveness of diagnostic and therapeutic measures.

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Brain Derived Neurotrophic Factor as a Non-invasive Biomarker for Detection of Endometriosis

Cited by 5 publications

References 27 publications

Brain-derived neurotrophic factor (BDNF) as a potential marker of endometriosis: a systematic review and meta-analysis

Brain-derived neurotrophic factor (BDNF) as a potential marker of endometriosis: a systematic review and meta-analysis

Brain Derived Neurotrophin Factor (BDNF) as a clinical marker of endometriosis

Actualization of differential diagnosis of chronic pelvic pain syndrome in women of reproductive age

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