Brain-derived neurotrophic factor blood levels in two models of transient brain ischemia in rats

Abstract

Abstract. We monitored possible influence of transient focal and global brain ischemia on BDNF blood level. In both models noticeable fluctuation of BDNF concentration mainly in reperfusion was observed. During the first 90 min, BDNF in total blood and in blood cells continuously decreased in both models but plasma BDNF raised at 40 min and peaked at 90 min of reperfusion. Our data confirm the impact of transient brain ischemia on BDNF levels in the circulatory system, suggest blood cells as a possible source of BDNF and demonstrate the interdependence of blood compartments and physiological state of an affected organism.

MAPK pathway mediates the anti‑oxidative effect of chicoric acid against cerebral ischemia‑reperfusion injury in�vivo

“…This results in oxygen deprivation to the brain leading to ischemia or necrosis (2). Following cerebral ischemic stroke, hemoperfusion of the ischemic region may be achieved by dissolution of the thrombus or recanalization (3). However, organizational functions are not recovered in certain patients and the damage is aggravated.…”

Neurovascular Unit as a Source of Ischemic Stroke Biomarkers—Limitations of Experimental Studies and Perspectives for Clinical Application

“…Some authors stress practically important differences in the BDNF levels detected in the whole blood and blood serum, which can result from its considerably high content in the blood cells. This must be taken into account while interpreting the diagnostic results relaying on assessment of the concentration of this neurotrophin [209].…”

Blocking gephyrin phosphorylation or microglia BDNF signaling prevents synapse loss and reduces infarct volume after ischemia

“…Under physiological conditions, glutamatergic neurotransmission induces BDNF expression 15 . BDNF is expressed as a proprotein, proBDNF, and is subsequently processed to its mature form mBDNF 16 .…”