Brain-derived neurotrophic factor Val66Met polymorphism is associated with mild cognitive impairment in elderly patients with type 2 diabetes: a case-controlled study

Liu, Jia; Yang, Wei; Luo, Hongyu; Ma, Yixin; Zhao, Huan; Dan, Xiaojuan

doi:10.1007/s40520-020-01687-w

Cited by 5 publications

(2 citation statements)

References 49 publications

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“… 2 Cognitive impairment is a common comorbidity of diabetes, especially in elderly populations. 3 Our previous meta-analysis found that about 45% of people with diabetes have mild cognitive impairment (MCI). 4 MCI is a transitional condition between normal cognitive function and dementia.…”

Section: Introductionmentioning

confidence: 99%

Gender differences in the association between physical activity and cognitive subdomains among elders with type 2 diabetes and mild cognitive impairment: a cross-sectional study

Xie,

You,

Zheng

et al. 2024

BMJ Open

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ObjectivesThe objective of this study was to evaluate the gender differences in the correlation between physical activity (PA) and cognitive subdomains in elderly individuals with type 2 diabetes (T2D) and mild cognitive impairment (MCI).DesignCross-sectional study.SettingThe research was carried out in communities located in Fuzhou, Fujian Province and Beijing Municipality.ParticipantsCommunity-dwelling elders with T2D and MCI aged 60 years or older were eligible for this study.Primary outcome measures and analysesThe weekly PA score was assessed using the International Physical Activity Questionnaire (IPAQ). The cognitive subdomains were evaluated through a battery of cognitive assessments, including the Rey Auditory Verbal Learning Test (RAVLT), Trail Making Test Part B, Digit Symbol Substitution Test (DSST) and the Stroop Color-Word Test (SCWT). Multiple linear regression models were employed to examine the association between PA and cognitive subdomains in both male and female individuals.ResultsIn older men, higher total IPAQ score was positively correlated with higher RAVLT (P=0.011) and SCWT (P=0.049). There was a significant interaction between the total PA score and gender in relation to RAVLT (P=0.008) and SCWT (P=0.027). Moreover, there was a positive correlation between moderate-vigorous PA level and RAVLT in older men (P=0.007). Additionally, a positive correlation was found between moderate-vigorous PA level and DSST in older women (P=0.038).ConclusionIn older individuals with T2D and MCI, the association between PA and cognitive subdomains differs between men and women. This discrepancy may impact the customisation of exercise recommendations.

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Section: Introductionmentioning

confidence: 99%

Gender differences in the association between physical activity and cognitive subdomains among elders with type 2 diabetes and mild cognitive impairment: a cross-sectional study

Xie,

You,

Zheng

et al. 2024

BMJ Open

View full text Add to dashboard Cite

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“…The incidence of mild cognitive impairment (MCI) among T2DM patients has increased by 50%–60%. MCI is the prodromal stage of Alzheimer’s disease (AD), and diabetes can accelerate the transition from MCI to AD (Li et al, 2020 ; Liu et al, 2021 ). Therefore, early diagnosis and treatment intervention for T2DM patients with MCI may reduce the occurrence and deterioration of cognitive impairment (Li et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Brain Structure as a Correlate of Odor Identification and Cognition in Type 2 Diabetes

Chen

Wang

Zhou

et al. 2022

Front. Hum. Neurosci.

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Background: It has been reported that type 2 diabetes (T2DM) is associated with olfactory identification (OI) impairments and cognitive decline. However, the relationship between OI impairments and cognitive decline is largely unknown in T2DM patients.Methods: Sixty-eight T2DM patients and 68 healthy controls underwent 3D-T1 MRI scans, olfactory and cognitive assessments. The cortical thickness of olfaction-related brain regions, olfactory and cognitive scores were compared between groups. Correlation analyses were carried out among cognition, olfaction, and cortical thickness of olfaction-related brain regions.Results: First, the cognitive and olfactory test scores of T2DM patients were lower than healthy subjects. Second, higher olfactory scores were associated with increased cortical thickness in the left parahippocampal gyrus and bilateral insula in T2DM. Third, higher olfactory scores were associated with higher cognitive performance in T2DM. Fourth, some cognitive performances were related to cortical thickness in the left parahippocampal gyrus and left insula in T2DM.Conclusion: These findings indicated that olfactory dysfunction may be useful for future applications that attempt to predict cognitive decline or develop tailored therapies in T2DM patients.

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The relationship between diabetes-related cognitive dysfunction and leukoaraiosis

Yuan

Dong

et al. 2021

Acta Neurol Belg

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Brain-derived neurotrophic factor Val66Met polymorphism is associated with mild cognitive impairment in elderly patients with type 2 diabetes: a case-controlled study

Cited by 5 publications

References 49 publications

Gender differences in the association between physical activity and cognitive subdomains among elders with type 2 diabetes and mild cognitive impairment: a cross-sectional study

Gender differences in the association between physical activity and cognitive subdomains among elders with type 2 diabetes and mild cognitive impairment: a cross-sectional study

Brain Structure as a Correlate of Odor Identification and Cognition in Type 2 Diabetes

The relationship between diabetes-related cognitive dysfunction and leukoaraiosis

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