Brain dynamics predictive of response to psilocybin for treatment-resistant depression

Vohryzek, Jakub; Cabral, Joana; Lord, Louis-David; Fernandes, Henrique M; Roseman, Leor; Nutt, David; Carhart‐Harris, Robin; Deco, Gustavo; Kringelbach, Morten L.

doi:10.21203/rs.3.rs-2060381/v1

Cited by 6 publications

(1 citation statement)

References 51 publications

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“…The important role of 5‐HT 2A receptor agonism in psychedelics’ mechanism of action is widely agreed upon 67–70,73,74 . Recent examination of brain regions involved in response to psilocybin‐based therapy for depression showed brain regions associated with restoration of healthy brain function to overlap significantly with 5‐HT 2A and 5‐HT 1A receptor affinity maps 75 . Research has shown dense presentation of 5‐HT 2A receptors in regions of the brain associated with music perception and music‐evoked emotion 76 .…”

Section: Common Brain Network In Music and Psychedelicsmentioning

confidence: 99%

Psychedelia: The interplay of music and psychedelics

Jerotic,

Vuust,

Kringelbach

2023

Annals of the New York Academy of Sciences

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Music and psychedelics have been intertwined throughout the existence of Homo sapiens, from the early shamanic rituals of the Americas and Africa to the modern use of psychedelic‐assisted therapy for a variety of mental health conditions. Across such settings, music has been highly prized for its ability to guide the psychedelic experience. Here, we examine the interplay between music and psychedelics, starting by describing their association with the brain's functional hierarchy that is relied upon for music perception and its psychedelic‐induced manipulation, as well as an exploration of the limited research on their mechanistic neural overlap. We explore music's role in Western psychedelic therapy and the use of music in indigenous psychedelic rituals, with a specific focus on ayahuasca and the Santo Daime Church. Furthermore, we explore work relating to the evolution and onset of music and psychedelic use. Finally, we consider music's potential to lead to altered states of consciousness in the absence of psychedelics as well as the development of psychedelic music. Here, we provide an overview of several perspectives on the interaction between psychedelic use and music—a topic with growing interest given increasing excitement relating to the therapeutic efficacy of psychedelic interventions.

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Section: Common Brain Network In Music and Psychedelicsmentioning

confidence: 99%

Psychedelia: The interplay of music and psychedelics

Jerotic,

Vuust,

Kringelbach

2023

Annals of the New York Academy of Sciences

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Dynamic sensitivity analysis: Defining personalised strategies to drive brain state transitions via whole brain modelling

Vohryzek¹,

Cabral²,

Castaldo³

et al. 2023

Computational and Structural Biotechnology Journal

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Using in silico perturbational approach to identify critical areas in schizophrenia

Mana

Vila-Vidal

Köckeritz

et al. 2022

Preprint

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Schizophrenia is a debilitating neuropsychiatric disorder whose underlying correlates remain unclear despite decades of neuroimaging investigation. One contentious topic concerns the role of global signal fluctuations and how they affect more focal functional changes. Moreover, it has been difficult to pinpoint causal mechanisms of circuit disruption. Here we analysed resting-state fMRI data from 47 schizophrenia patients and 118 age-matched healthy controls and used dynamical analyses to investigate how global fluctuations and other functional metastable states are affected by this disorder. We then used in-silico perturbation of a whole-brain model to identify critical areas involved in the disease. We found that brain dynamics in the schizophrenic group were characterised by an increased probability of globally coherent states and reduced recurrence of a substate dominated by coupled activity in the default mode and limbic networks. Perturbing a set of temporoparietal sensory and associative areas in a model of the healthy brain reproduced global pathological dynamics. Healthy brain dynamics were instead restored by perturbing a set of medial fronto-temporal and cingulate regions in the model of pathology. These results highlight the relevance of global signal alterations in schizophrenia and identify a set of vulnerable areas involved in determining a shift in brain state.

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Brain dynamics predictive of response to psilocybin for treatment-resistant depression

Cited by 6 publications

References 51 publications

Psychedelia: The interplay of music and psychedelics

Psychedelia: The interplay of music and psychedelics

Dynamic sensitivity analysis: Defining personalised strategies to drive brain state transitions via whole brain modelling

Using in silico perturbational approach to identify critical areas in schizophrenia

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