Brain Enhancing Ingredients from Āyurvedic Medicine: Quintessential Example of Bacopa monniera,  a Narrative Review

Singh, Hemant Kumar

doi:10.3390/nu5020478

Cited by 33 publications

(24 citation statements)

References 22 publications

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“…The powdered Ayurvedic herbal drug mixture used in this patient primarily targets adaptogenic, rejuvenative, aphrodisiac, and general strengthening as well as strengthening of the reproductive tissues; it helps enhancing digestion and cognition and has mild anxiolytic and antidepressant properties ( W. somnifera [50,51,52,53,54,55], A. racemosus [56,57,58,59,60,61], T. cordifolia [62,63,64,65,] B. monnieri [66,67,68,69,70])[. ]…”

Section: Conclusion and Discussionmentioning

confidence: 99%

The Effect of a Complex Multi-modality Ayurvedic Treatment in a Case of Unknown Female Infertility

Kessler

Stapelfeldt²,

Michalsen

et al. 2015

Complement Med Res

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Background: Treatment of female infertility has been growing globally in recent years. In spite of improvements in medical strategies and the improved outcomes for infertile couples, treatment attempts remain largely unsuccessful. A growing number of patients pursue complementary and alternative medicine treatment options like Ayurveda that offers a variety of inpatient and outpatient treatments for infertility. Case Report: A case of a 38 year-old woman with infertility of unknown origin is presented. She received 18 conventional fertility treatments in 5 different fertility centers and 3 different countries. After several complications, the patient quitted conventional treatment and admitted to an Ayurvedic outpatient clinic where she received a complex Ayurvedic treatment, which included botanicals, dietary and lifestyle advice, manual therapy, yoga, and spiritual elements. The patient then became pregnant and gave birth to a healthy boy in 2012. Conclusions: Ayurveda may be a useful complementary option in the case of futile conventional treatment attempts in female infertility. Nevertheless, the evidence base for Ayurvedic interventions remains weak and requires well-designed clinical trials. This case raises some questions, such as whether the exposure to a large number of assisted reproduction procedures can lead to more health problems than health benefits. The Ayurvedic approach to fertility strives first to improve the health of the patient leading to a higher likelihood of pregnancy. As this is a case report, we are not able to exclude temporal factors stimulating the pregnancy. However, the chronology suggests that this approach might have been an important factor in the eventual pregnancy.

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Section: Conclusion and Discussionmentioning

confidence: 99%

The Effect of a Complex Multi-modality Ayurvedic Treatment in a Case of Unknown Female Infertility

Kessler

Stapelfeldt²,

Michalsen

et al. 2015

Complement Med Res

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“…This includes not only synthetic chemicals but also naturally derived compounds [46,47]. The latter not only includes isolated naturally occurring compounds but also the identification and use of, e.g., plants and herbs used in traditional Chinese medicine (TCM) and ayurvedic medicine native to the Indian subcontinent [47-50]. Natural product extracts can function as disease-modifying therapies, but this potential has rarely been critically evaluated in vivo ; and as traditional medicines, many TCM and ayurvedic products have not been tested in rigorous scientific studies and clinical trials.…”

Section: Pharmacologic Stimulation Of Endogenous Neurogenesismentioning

confidence: 99%

“…For example, polyphenolic compounds in the extracts might function as anti-aggregation agents or anti-oxidants, and plant sterols could have numerous neuroprotective actions or anti-inflammatory actions and possibly directly impact Aβ production [50,53,54]. Thus, it is entirely possible that an extract could prove more efficacious in vivo because it contains multiple agents that target multiple pathologies.…”

Section: Pharmacologic Stimulation Of Endogenous Neurogenesismentioning

confidence: 99%

Regenerative medicine in Alzheimer's disease

Felsenstein

Steindler

Borchelt

2014

Translational Research

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Identifying novel, effective therapeutics for Alzheimer's disease (AD) is one of the major unmet medical needs for the coming decade. Because the current paradigm for developing and testing disease modifying AD therapies is protracted and likely to be even longer with the shift towards earlier intervention in pre-clinical AD, it is an open question whether we can develop, test, and widely deploy a novel therapy in time to help the current at-risk generation if we continue to follow the standard paradigms of discovery and drug development. There is an imperative need to find safe and effective preventative measures that can be rapidly deployed to stem the coming wave of AD that will potentially engulf the next generation. We can broadly define regenerative medicine as approaches that use stem-cell-based therapies or approaches that seek to modulate inherent neurogenesis. Neurogenesis, though most active during pre-natal development has been shown to continue in several small parts of the brain, which includes the hippocampus and the subventricular zone, suggesting its potential to reverse cognitive deficits. If AD pathology impacts neurogenesis then it follows that conditions that stimulate endogenous neurogenesis (e.g., environmental stimuli, physical activity, trophic factors, cytokines, and drugs) may help to promote the regenerative and recovery process. Herein, we review the complex logistics of potentially implementing neurogenesis-based therapeutic strategies for the treatment of AD.

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“…B monnieri is also a good source of elements (Łojewski et al 2014). The currently used, standardized extract of Bacopa, is CDRI-08 (Singh 2013). This paper presents a study of the optimal culture medium for the effective enhancement of the production of metabolites in B. monnieri.…”

Section: Introductionmentioning

confidence: 99%

In vitrocultures ofBacopa monnieriand an analysis of selected groups of biologically active metabolites in their biomass

Muszyńska

Łojewski

Sułkowska-Ziaja

et al. 2016

Pharmaceutical Biology

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Context: Bacopa monnieri L. Pennell (Scrophulariaceae) is one of the most important plants in the system of Indian medicine (Ayurveda). Objective: This paper studies the optimal growth of B. monnieri for effective accumulation of metabolites. Biomass growth of this plant could be accomplished in liquid cultures on Murashige & Skoog medium. Materials and methods: Powdered shoots of in vitro cultures of B. monnieri were extracted by methanol for indole compounds, phenolic compounds and bacosides for RP-HPLC analysis. Fatty acid analysis was performed via gas chromatography. Anti-inflammatory effect of B. monnieri extracts was evaluated in the A549 cells. COX-2 and cPGES expression was analyzed using Western blots. Results: L-Tryptophan and serotonin were found in biomass from in vitro cultures of B. monnieri on MS medium and in biomass from the MS mediums enriched with the different additions such as of 0.1 g/L magnesium sulphate, 0.1 g/L zinc hydroaspartate, 0.1 g/L L-tryptophan, 0.25 g/L serine, 0.5 g/L serine and 0.5 mg/L anthranilic acid. The content of L-tryptophan and serotonin compounds was significant in biomass from medium with the addition of 0.1 g/L zinc hydroaspartate (0.72 mg/g dry weight and 1.19, respectively). Phenolic compounds identified in biomass from the same variants of MS medium were chlorogenic acid (ranging from 0.20 to 0.70 mg/g dry weight), neochlorogenic acid (ranging from 0.11 to 0.40 mg/g dry weight) and caffeic acid (ranging from 0.01 to 0.04 mg/g dry weight). The main group of fatty acids in biomass was saturated fatty acids (53.4%). The predominant fatty acid was palmitic acid. A significant decrease of COX-2 and cPGES expression was observed in the A549 cells activated with LPS and treated with B. monnieri extracts. Discussion and conclusions: As far as we know, this is the first analysis of indole compounds and phenolic acids in this plant. The multi-therapeutic effect of B. monnieri is expressed by the activity of bacosides. Information about the presence of indole and phenolic compounds, and fatty acids in this plant is limited, but the content of these compounds might participate in the physiological activity of B. monnieri. ARTICLE HISTORY

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Brain Enhancing Ingredients from Āyurvedic Medicine: Quintessential Example of Bacopa monniera, a Narrative Review

Cited by 33 publications

References 22 publications

The Effect of a Complex Multi-modality Ayurvedic Treatment in a Case of Unknown Female Infertility

The Effect of a Complex Multi-modality Ayurvedic Treatment in a Case of Unknown Female Infertility

Regenerative medicine in Alzheimer's disease

In vitrocultures ofBacopa monnieriand an analysis of selected groups of biologically active metabolites in their biomass

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