Brain-gut interactions in ulcerative colitis

Peck, Owen C.; Wood, Jackie D.

doi:10.1016/s0016-5085(00)70157-0

Cited by 19 publications

(10 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the evidence obtained from our studies of the only known nonhuman primate model for spontaneous colitis and colon cancer supported a hypothesis of a braingut connection in colitis [40][41][42][43][44]. Severe colitis was found in 80-85 percent of the tamarins in the Ohio State colony during semiannual colonoscopically obtained biopsies.…”

Section: Contributions To Digestive Sciencesupporting

confidence: 67%

GRG Profiles: Jackie D. Wood

Wood

2016

Dig Dis Sci

Self Cite

View full text Add to dashboard Cite

Section: Contributions To Digestive Sciencesupporting

confidence: 67%

GRG Profiles: Jackie D. Wood

Wood

2016

Dig Dis Sci

Self Cite

View full text Add to dashboard Cite

“…Inversely, it has been shown that the brain and spinal cord may modulate inflammation in IBD. 15,16 Neurological and other extraintestinal manifestations of IBD CD and UC are the two major types of IBD. Three main factors are thought to be involved in the development of chronic inflammation in IBD 17 : a reaction to a persistent intestinal infection; a defective mucosal barrier to luminal antigens; and a dysregulation of the immune response to ubiquitous antigens in a host with genetically determined susceptibility.…”

Section: Brain-gut Interactionsmentioning

confidence: 99%

Multiple sclerosis and inflammatory bowel diseases: what we know and what we would need to know!

et al. 2012

View full text Add to dashboard Cite

Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system (CNS) but the causes have not been defined. The disease process appears to involve interplay between environmental factors and certain susceptibility genes. It is likely that the identification of the exact etiological mechanisms will permit the development of preventive and curative treatments. Evaluation of several diseases found to be more often associated than by chance alone may reveal clues to the etiology of those disorders. An association between MS and inflammatory bowel diseases (IBD) was suggested by the observation of an increased incidence of IBD among MS patients. A problem in the interpretation of the data rests, in part, with the observation that abnormal findings in brain magnetic resonance imaging (MRI) may be reported as MS in IBD patients. Defining the limits between incidental MRI findings and findings compatible with MS has resulted in further exploration of this possible association.

show abstract

“…Anecdotal evidence for the link between the nervous and GI inflammatory systems comes from examples such as that of a man whose previously refractory UC went into complete remission following a cervical Brown-Séquard paralysis [8] and another patient who suffered recurrent flares of his UC in association with spinal cord stimulation given for post-traumatic pain in his arm [9] .…”

Section: The Brain-gut Axismentioning

confidence: 99%

The Role of Psychological Stress in Inflammatory Bowel Disease

Mawdsley

Rampton²

2006

Neuroimmunomodulation

103

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is an idiopathic inflammatory condition of the gastrointestinal tract whose natural history is one of periods of remission and relapse. The aetiology is complex and reflects an interaction between genes and environment. Psychological stress has long been reported by both doctors and patients as worsening disease activity in IBD. Prospective studies of the relationship between disease relapse and adverse life events have produced conflicting results, in part due to the inherent difficulties of such studies. However, several more recent analyses have suggested that both adverse life events and chronic perceived stress can contribute to disease relapse. There is also an increasing body of evidence to suggest that experimental stress can increase mucosal inflammation both in patients with IBD and in animal models of colitis. Despite this increase in understanding the pro-inflammatory effects of stress in IBD, thus far only a few limited studies have examined stress reduction as a therapeutic modality.

show abstract

Brain-gut interactions in ulcerative colitis

Cited by 19 publications

References 6 publications

GRG Profiles: Jackie D. Wood

GRG Profiles: Jackie D. Wood

Multiple sclerosis and inflammatory bowel diseases: what we know and what we would need to know!

The Role of Psychological Stress in Inflammatory Bowel Disease

Contact Info

Product

Resources

About