Brain Histopathological Changes After Treatment Using Calabash Fruit (Crescentia cujete L.) in Rat Model with Artificially Induced Ischemic Stroke

Abstract

T he brain is an essential neurological system in humans and animals. Brain function can be destroyed through circulatory system disturbance, such as thrombus. Thrombus causes a significant decrease in the blood supply that not to carry nutrition, oxygen and other blood components to the brain tissue. Further, they promote severe stress within the neuronal tissue and cause neuronal death (Kuriakose and Xiao, 2020). In advance, it triggers partial infarction within brain tissue and causes ischemic stroke. An ischemic stroke is the highest prevalence in humans,