Brain imaging correlates of self- and other-reflection in schizophrenia

Fuentes‐Claramonte, Paola; Martin-Subero, Marta; Salgado‐Pineda, Pilar; Santo-Angles, Aniol; Argila-Plaza, Isabel; Salavert, J.; Arevalo, Antoni; Bosque, Clara; Sarri, C.; Guerrero-Pedraza, Amalia; Capdevila, Antoni; Sarró, Salvador; McKenna, Peter; Pomarol‐Clotet, Edith; Salvador, Raymond

doi:10.1016/j.nicl.2019.102134

Cited by 20 publications

(9 citation statements)

References 52 publications

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“…The TPJ was more activated in FER tasks in SSD patients, in comparison to ASD individuals (79). The involvement of TPJ in the SC process has also been demonstrated in more recent studies in patients with SSD (88,109) and ASD (89).…”

Section: Temporal Lobe Regionssupporting

confidence: 60%

“…The finding of reduced ventrolateral PFC, implying connection to social appropriateness of behavior, may be more relevant to SSD patients, while in both disorders, reduced medial PFC activation may contribute to alterations in conscious awareness of others' emotional states (79). Further studies using fMRI in social tasks have demonstrated heterogeneous results, with either hypoactivation in the medial PFC in patients with ASD (86) and SSD (87) and a hyperactivation of the PFC in patients with SSD (88) and ASD (89). The involvement of the PFC in SC impairment has also been demonstrated in morphometric studies, suggesting a reduction in the PFC gray matter volume in patients with ASD (78,89) and in those with SSD (90).…”

Section: Prefrontal Cortexmentioning

confidence: 99%

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Social Cognition in a Research Domain Criteria Perspective: A Bridge Between Schizophrenia and Autism Spectra Disorders

et al. 2020

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Schizophrenia and autism spectra disorders are currently conceptualized as distinct clinical categories. However, the relationship between these two nosological entities has been revisited in recent years due to the evidence that they share some important clinical and neurobiological features, putting into question the nature and the extent of their commonalities and differences. In this respect, some core symptoms that are present in both disorders, such as social cognitive deficits, could be a primary target of investigation. This review briefly summarizes the commonalities and overlapping features between schizophrenia and autism spectra disorders in social cognitive functions, considering this construct in a Research Domain Criteria perspective. The clinical manifestation of deficits in social cognition are similar in schizophrenia spectrum disorders and autism spectrum disorders, and brain areas that appear to be altered in relation to these impairments are largely shared; however, the results of various studies suggest that, in some cases, the qualitative nature of these alterations may be different in the two spectra. Moreover, relevant differences could be present at the level of brain networks and connections. More research is required in this field, regarding molecular and genetic aspects of both spectra, to better define the neurobiological mechanisms involved in social cognition deficits, with the objective of developing specific and targeted treatments.

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Section: Temporal Lobe Regionssupporting

confidence: 60%

Section: Prefrontal Cortexmentioning

confidence: 99%

Social Cognition in a Research Domain Criteria Perspective: A Bridge Between Schizophrenia and Autism Spectra Disorders

et al. 2020

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“…However, this assumption somewhat contradicts the findings of Sui, Chechlacz, et al (2015) in which damage to the LpSTS increases the The negative results might be because other brain areas are also involved in processing information about others. For example, the temporoparietal junction (TPJ) is crucial for self/other differentiation (Brass, Ruby, & Spengler, 2009;Fuentes-Claramonte et al, 2020;Spengler, von Cramon, & Brass, 2009), facilitating the processing of others (van der Meer et al, 2011), and is more responsive to others (Pfeifer et al, 2013). Future research should measure changes in Schafer & Frings, 2019).…”

Section: Discussionmentioning

confidence: 99%

The roles of the LpSTS and DLPFC in self‐prioritization: A transcranial magnetic stimulation study

Liang

Zhang

et al. 2021

Human Brain Mapping

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The Self-Attention Network (SAN) has been proposed to describe the underlying neural mechanism of the self-prioritization effect, yet the roles of the key nodes in the SAN-the left posterior superior temporal sulcus (LpSTS) and the dorsolateral prefrontal cortex (DLPFC)-still need to be clarified. One hundred and nine participants were randomly assigned into the LpSTS group, the DLPFC group, or the sham group. We used the transcranial magnetic stimulation (TMS) technique to selectively disrupt the functions of the corresponding targeted region, and observed its impacts on self-prioritization effect based on the difference between the performance of the self-matching task before and after the targeted stimulation. We analyzed both model-free performance measures and HDDM-based performance measures for the self-matching task. The results showed that the inhibition of LpSTS could lead to reduced performance in processing self-related stimuli, which establishes a causal role for the LpSTS in self-related processing and provide direct evidence to support the SAN framework. However, the results of the DLPFC group from HDDM analysis were distinct from the results based on response efficiency. Our investigation further the understanding of the differentiated roles of key nodes in the SAN in supporting the self-salience in information processing.

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“…For example, van der Meer et al reported precuneus/PCC hypo activation for a self-vs.-baseline contrast in schizophrenia patients ( 42 ) and Zhang et al found similarly located hypoactivations in bipolar disorder patients, with schizophrenia patients showing an intermediate effect ( 43 ). Other regions, including the left inferior temporal gyrus, bilateral temporal poles ( 44 ), and left lateral frontal cortex ( 45 ) have also been implicated. These divergent results may relate to differences in experimental paradigms including baseline conditions ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis

et al. 2021

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Patients with schizophrenia spectrum disorders show disturbances in self-referential processing and associated neural circuits including the default mode network (DMN). These disturbances may precede the onset of psychosis and may underlie early social and emotional problems. In this study, we examined self-referential processing in a group of children (7–12 years) at familial high risk (FHR) for psychosis (N = 17), compared to an age and sex-matched group of healthy control (HC) children (N = 20). The participants were presented with a list of adjectives and asked to indicate whether or not the adjectives described them (self-reference condition) and whether the adjectives described a good or bad trait (semantic condition). Three participants were excluded due to chance-level performance on the semantic task, leaving N = 15 FHR and N = 19 HC for final analysis. Functional MRI (fMRI) was used to measure brain activation during self-referential vs. semantic processing. Internalizing and externalizing problems were assessed with the Child Behavior Checklist (CBCL). Evaluating main effects of task (self > semantic) showed activation of medial prefrontal cortex in HC and precuneus/posterior cingulate cortex (PCC) in FHR. Group-comparison yielded significant results for the FHR > HC contrast, showing two clusters of hyperactivation in precuneus/ PCC (p = 0.004) and anterior cerebellum / temporo-occipital cortex (p = 0.009). Greater precuneus/PCC activation was found to correlate with greater CBCL internalizing (r = 0.60, p = 0.032) and total (r = 0.69, p = 0.009) problems. In all, this study shows hyperactivity of posterior DMN during self-referential processing in pre-adolescent FHR children. This finding posits DMN-related disturbances in self-processing as a developmental brain abnormality associated with familial risk factors that predates not just psychosis, but also the prodromal stage. Moreover, our results suggest that early disturbances in self-referential processing may be related to internalizing problems in at-risk children.

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Brain imaging correlates of self- and other-reflection in schizophrenia

Cited by 20 publications

References 52 publications

Social Cognition in a Research Domain Criteria Perspective: A Bridge Between Schizophrenia and Autism Spectra Disorders

Social Cognition in a Research Domain Criteria Perspective: A Bridge Between Schizophrenia and Autism Spectra Disorders

The roles of the LpSTS and DLPFC in self‐prioritization: A transcranial magnetic stimulation study

Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis

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