Brain iron content and cognitive function in patients with β-thalassemia

Bu, Meiru; Deng, Xi; Chen, Sean W.; Jiang, Muliang; Chen, Bihong T.

doi:10.1177/20406207231167050

Cited by 5 publications

(1 citation statement)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A neuroimaging study found that iron content in the brain can be quantified using many MRI techniques, including transverse relaxation rate, susceptibility-weighted imaging, and quantitative susceptibility mapping [46]. Interestingly, serum ferritin levels do not accurately reflect the iron stored in the brain [47].…”

Section: Neurophysiology Of Thalassemia Patients and Its Association ...mentioning

confidence: 99%

Psychological Burden among Pediatric Thalassemia Major Patients in Indonesia: A Review

Sari,

Rahmartani,

Wirahmadi

et al. 2024

Thalassemia Reports

View full text Add to dashboard Cite

Thalassemia a common hereditary blood disorder resulting in anemia. It is an important public health problem, with a high prevalence in Southeast Asia and Mediterranean countries, and preventable through screening programs. However, due to its chronic nature, permanent physical changes, troublesome complications, and lifelong treatment, pediatric patients with thalassemia major are more prone to mental disorders and cognitive impairment. Internalizing and externalizing problems are higher in pediatric patients with thalassemia. Children with β-thalassemia major exhibit lower IQ scores than healthy children. Neurophysiology and neuroimaging examinations have shown abnormal results in children with thalassemia. Co-morbidity with mental disorders increases the mortality, morbidity, and total healthcare costs of patients with thalassemia. Therefore, routine evaluation of mental health problems is recommended to accommodate the early detection and prompt treatment of mental disorders. A multidisciplinary approach for thalassemia patients and families should be delivered by providing appropriate medical care, psychosocial support, and good transition care to improve survival and well-being, assist good social integration and daily functioning, and cope with the stress of chronic disease.

show abstract

Section: Neurophysiology Of Thalassemia Patients and Its Association ...mentioning

confidence: 99%

Psychological Burden among Pediatric Thalassemia Major Patients in Indonesia: A Review

Sari,

Rahmartani,

Wirahmadi

et al. 2024

Thalassemia Reports

View full text Add to dashboard Cite

show abstract

Quality of life, mood disorders, and cognitive impairment in adults with β-thalassemia

Bizri,

Koleilat,

Akiki

et al. 2024

Blood Reviews

View full text Add to dashboard Cite

Exploring alterations of gut/blood microbes in addressing iron overload-induced gut dysbiosis and cognitive impairment in thalassemia patients

Suparan,

Trirattanapa,

Piriyakhuntorn

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Iron overload causes cognitive impairment in thalassemia patients. The gut-brain axis plays an important role in cognitive function. However, the association between gut/blood microbiome, cognition, and iron burden in thalassemia patients has not been thoroughly investigated. We aimed to determine those associations in thalassemia patients with different blood-transfusion regimens. Sixty participants: healthy controls, transfusion-dependent thalassemia (TDT) patients, and non-transfusion-dependent (NTDT) patients, were recruited to evaluate iron overload, cognition, and gut/blood microbiome. TDT patients exhibited greater iron overload than NTDT patients. Most thalassemia patients developed gut dysbiosis, and approximately 25% of the patients developed minor cognitive impairment. Increased Fusobacteriota and Verrucomicrobiota with decreased Fibrobacterota were observed in both TDT and NTDT groups. TDT patients showed more abundant beneficial bacteria: Verrucomicrobia. Iron overload was correlated with cognitive impairment. Increased Butyricimonas and decreased Paraclostridium were associated with higher cognitive function. No trace of blood microbiota was observed. Differences in blood bacterial profiles of thalassemia patients and controls were insignificant. These findings suggest iron overload plays a role in the imbalance of gut microbiota and impaired cognitive function in thalassemia patients. Harnessing probiotic potential from those microbes could prevent the gut-brain disturbance in thalassemia patients. Supplementary Information The online version contains supplementary material available at 10.1038/s41598-024-76684-4.

show abstract

Brain iron content and cognitive function in patients with β-thalassemia

Cited by 5 publications

References 82 publications

Psychological Burden among Pediatric Thalassemia Major Patients in Indonesia: A Review

Psychological Burden among Pediatric Thalassemia Major Patients in Indonesia: A Review

Quality of life, mood disorders, and cognitive impairment in adults with β-thalassemia

Exploring alterations of gut/blood microbes in addressing iron overload-induced gut dysbiosis and cognitive impairment in thalassemia patients

Contact Info

Product

Resources

About