Brain lipidomic changes after morphine, cocaine and amphetamine administration — DESI — MS imaging study

Bodzoń‐Kułakowska, Anna; Antolak, Anna; Drabik, Anna; Marszałek‐Grabska, Marta; Kotlińska, Jolanta; Suder, Piotr

doi:10.1016/j.bbalip.2017.04.003

Cited by 20 publications

(15 citation statements)

References 38 publications

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“…A few studies have used MSI to analyze cocaine drug and metabolites (Pirman, Reich, Kiss, Heeren, & Yost, ; Wang, Jackson, McEuen, & Woods, ); however, the current study is one of the first to report the persisting effects of cocaine on differential lipid abundance with MSI. A recent study by Bodzon‐Kulakowska et al () demonstrated the influence of cocaine, morphine, and amphetamine on select PL species throughout limbic structures using desorption electrospray MSI. Comparison of this study to ours demonstrated a few of the same PLs alterations ( m / z 834.5, m / z 786.5, m / z 806.6).…”

Section: Discussionmentioning

confidence: 99%

“…Comparison of this study to ours demonstrated a few of the same PLs alterations ( m / z 834.5, m / z 786.5, m / z 806.6). These similarities occurred despite differences between the behavioral regimens used as well as differences in the dose and frequency of cocaine administration (Bodzon‐Kulakowska et al, ). Another recent study showed the profound effect of cocaine on the brain lipidome in mice using behavioral models of CPP and locomotor sensitization (Lin et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Following our initial report (Cummings et al, ), other investigators (Bodzon‐Kulakowska et al, ; Lin et al, ) have recently explored the effects of drug exposure on the brain lipidome. Here, in the present study, we assess brain region‐specific lipid remodeling within a rodent model of drug exposure.…”

Section: Introductionmentioning

confidence: 99%

“…Following our initial report (Cummings et al, 2015), other investigators (Bodzon-Kulakowska et al, 2017;Lin et al, 2017) have recently explored the effects of drug exposure on the brain lipidome.…”

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confidence: 99%

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Lipidomic changes in the rat hippocampus following cocaine conditioning, extinction, and reinstatement of drug‐seeking

et al. 2019

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IntroductionCocaine dependence affects millions of individuals worldwide; however, there are no pharmacotherapeutic and/or diagnostic solutions. Recent evidence suggests a role for lipid signaling in the development and maintenance of addiction, highlighting the need to understand how lipid remodeling mediates neuroadaptation after cocaine exposure.MethodsThis study utilized shotgun lipidomics to assess cocaine‐induced lipid remodeling in rats using a novel behavioral regimen that incorporated multiple sessions of extinction training and reinstatement testing.ResultsMass spectrometric imaging demonstrated widespread decreases in phospholipid (PL) abundance throughout the brain, and high‐spatial resolution matrix‐assisted laser desorption/ionization Fourier‐transform ion cyclotron resonance mass spectrometry indicated hippocampus‐specific PL alterations following cocaine exposure. We analyzed the expression of genes involved in hippocampal lipid metabolism and observed region‐specific regulation. In addition, we found that cocaine exposure differentially regulates mitochondrial biogenesis in the brain.ConclusionsThis work presents a comprehensive lipidomic assessment of cocaine‐induced lipid remodeling in the rat brain. Further, these findings indicate a potential interplay between CNS energetics and differential lipid regulation and suggest a role for cocaine in the maintenance of energy homeostasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Lipidomic changes in the rat hippocampus following cocaine conditioning, extinction, and reinstatement of drug‐seeking

et al. 2019

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“…Concerning addiction, while the study of the brain circuits relevant for addictive-like behaviors is fundamental for its understanding and devising new therapies, there are a number of studies that tackle the direct impact of addictive substances exposure on sphingolipid brain metabolism. For instance, chronic ethanol consumption was shown to upregulate ceramide levels and decrease sphingomyelin levels in adult mouse brain [ 195 ] and while binging ethanol consumption decreased ceramide levels, ethanol withdrawal increased ceramide levels in the mouse cortex [ 196 ]; methamphetamine-sensitized mice had higher degree changes in the hippocampus and PFC lipidome, showing in both, decreased LacCer levels [ 197 ]; cocaine conditioned mice have widespread lipidomic alterations in the nucleus accumbens, striatum, PFC and hippocampus, notably showing decreased ceramide levels [ 198 ]; and using mass spectrometry imaging, administration of morphine, cocaine, and amphetamine in rodents was shown to lead to increased brain sulfatide levels [ 198 ].…”

Section: Sphingolipids In Psychiatric Diseasesmentioning

confidence: 99%

Sphingolipids as prognostic biomarkers of neurodegeneration, neuroinflammation, and psychiatric diseases and their emerging role in lipidomic investigation methods

Kruining

Luo

Echten‐Deckert

et al. 2020

Advanced Drug Delivery Reviews

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Lipids play an important role in neurodegeneration, neuroinflammation, and psychiatric disorders and an imbalance in sphingolipid levels is associated with disease. Although early diagnosis and intervention of these disorders would clearly have favorable long-term outcomes, no diagnostic tests currently exist that can accurately identify people at risk. Reliable prognostic biomarkers that are easily accessible would be beneficial to determine therapy and treatment response in clinical trials. Recent advances in lipidomic investigation methods have greatly progressed the knowledge of sphingolipids in neurodegenerative and psychiatric disorders over the past decades although more longitudinal studies are needed to understand its exact role in these disorders to be used as potential tools in the clinic. In this review, we give an overview of the current knowledge of sphingolipids in neurodegenerative and psychiatric disorders and explore recent advances in investigation methods. Finally, the potential of sphingolipid metabolism products and signaling molecules as potential biomarkers for diagnosis, prognostic, or surrogate markers of treatment response is discussed.

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Effects of dopants in the imaging of mouse brain by desorption electrospray ionization/post‐photoionization mass spectrometry

et al. 2022

J Mass Spectrom

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Desorption electrospray ionization/post‐photoionization (DESI/PI) is a newly developed ionization method by the combination of DESI and post‐photoionization for the simultaneous imaging of polar and nonpolar compounds in biological tissues. Dopants are of great importance in DESI/PI for the enhancement of signal intensities through ion–molecule reactions. In this work, to evaluate the performance of dopants in DESI/PI, an efficient homogenate model was developed, and four kinds of dopants (toluene, chlorobenzene, bromobenzene, and anisole) were tested using homogenate of mouse brain tissue as target sample. The influences of the dopants on the signal enhancements of different compounds were explained reasonably by the ionization mechanism. Then, the dopants with their optimum volume contents were applied to the mass spectrometry imaging (MSI). For a comprehensive imaging of various compounds with different polarities, methanol/toluene/formic acid (7:3:0.1) was chosen as the best choice. Finally, the stronger quantitative ability of DESI/PI with toluene as dopant for a few compounds in mouse brain tissue was demonstrated.

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Brain lipidomic changes after morphine, cocaine and amphetamine administration — DESI — MS imaging study

Cited by 20 publications

References 38 publications

Lipidomic changes in the rat hippocampus following cocaine conditioning, extinction, and reinstatement of drug‐seeking

Lipidomic changes in the rat hippocampus following cocaine conditioning, extinction, and reinstatement of drug‐seeking

Sphingolipids as prognostic biomarkers of neurodegeneration, neuroinflammation, and psychiatric diseases and their emerging role in lipidomic investigation methods

Effects of dopants in the imaging of mouse brain by desorption electrospray ionization/post‐photoionization mass spectrometry

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