Brain Networks Communicate Through Theta Oscillations to Encode High Load in a Visuospatial Working Memory Task: An EEG Connectivity Study

Muthukrishnan, Suriya Prakash; Soni, S. K.; Sharma, Ratna

doi:10.1007/s10548-019-00739-3

Cited by 30 publications

(22 citation statements)

References 98 publications

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“…Furthermore, a previous VBM-correlation analysis revealed that the superior and inferior frontal atrophy was significantly correlated with memory scores in MSA (Chang et al, 2009), which also supported the finding of the current study. The fusiform gyrus and lingual gyrus have been reported to encode visuospatial information (Muthukrishnan et al, 2020). The fusiform gyrus atrophy detected in both MSA-P and MSA-C subtypes was consistent with the clinical findings that visuospatial and constructional function was impaired in both MSA-P and MSA-C (Kawai et al, 2008).…”

Section: Cerebral Cortexsupporting

confidence: 81%

Voxel-Based Meta-Analysis of Gray Matter Abnormalities in Multiple System Atrophy

Lin

Hou

et al. 2020

Front. Aging Neurosci.

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Purpose: This study aimed to identify consistent gray matter volume (GMV) changes in the two subtypes of multiple system atrophy (MSA), including parkinsonism subtype (MSA-P), and cerebellar subtype (MSA-C), by conducting a voxel-wise meta-analysis of whole brain voxel-based morphometry (VBM) studies.Method: VBM studies comparing MSA-P or MSA-C and healthy controls (HCs) were systematically searched in the PubMed, Embase, and Web of Science published from 1974 to 20 October 2020. A quantitative meta-analysis of VBM studies on MSA-P or MSA-C was performed using the effect size-based signed differential mapping (ES-SDM) method separately. A complementary analysis was conducted using the Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) method, which allows a familywise error rate (FWE) correction for multiple comparisons of the results, for further validation of the results.Results: Ten studies were included in the meta-analysis of MSA-P subtype, comprising 136 MSA-P patients and 211 HCs. Five studies were included in the meta-analysis of MSA-C subtype, comprising 89 MSA-C patients and 134 HCs. Cerebellum atrophy was detected in both MSA-P and MSA-C, whereas basal ganglia atrophy was only detected in MSA-P. Cerebral cortex atrophy was detected in both subtypes, with predominant impairment of the superior temporal gyrus, inferior frontal gyrus, temporal pole, insula, and amygdala in MSA-P and predominant impairment of the superior temporal gyrus, middle temporal gyrus, fusiform gyrus, and lingual gyrus in MSA-C. Most of these results survived the FWE correction in the complementary analysis, except for the bilateral amygdala and the left caudate nucleus in MSA-P, and the right superior temporal gyrus and the right middle temporal gyrus in MSA-C. These findings remained robust in the jackknife sensitivity analysis, and no significant heterogeneity was detected.Conclusion: A different pattern of brain atrophy between MSA-P and MSA-C detected in the current study was in line with clinical manifestations and provided the evidence of the pathophysiology of the two subtypes of MSA.

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Section: Cerebral Cortexsupporting

confidence: 81%

Voxel-Based Meta-Analysis of Gray Matter Abnormalities in Multiple System Atrophy

Lin

Hou

et al. 2020

Front. Aging Neurosci.

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“…As neurons in the brain are highly interconnected , functional interactions among them could be a mechanism of information processing (Funahashi, 2006). Interactions between brain regions at the theta frequency have been reported in several studies of working memory, showing significant interregional theta synchronization involving the frontotemporal, frontoparietal, and fronto-occipital regions in auditory or visual item encoding (Sauseng et al, 2004;Kawasaki et al, 2010Kawasaki et al, , 2014Liebe et al, 2012;Muthukrishnan et al, 2020). Moreover, large-scale theta synchronization during working memory encoding is related to the co-activation of cortical networks and involves the critical coordination and integration of processes in the formation of memory traces (Wu et al, 2007;Sauseng et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Theta Oscillations and Source Connectivity During Complex Audiovisual Object Encoding in Working Memory

Xie

Li²,

Duan³

et al. 2021

Front. Hum. Neurosci.

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Working memory is a limited capacity memory system that involves the short-term storage and processing of information. Neuroscientific studies of working memory have mostly focused on the essential roles of neural oscillations during item encoding from single sensory modalities (e.g., visual and auditory). However, the characteristics of neural oscillations during multisensory encoding in working memory are rarely studied. Our study investigated the oscillation characteristics of neural signals in scalp electrodes and mapped functional brain connectivity while participants encoded complex audiovisual objects in a working memory task. Experimental results showed that theta oscillations (4–8 Hz) were prominent and topographically distributed across multiple cortical regions, including prefrontal (e.g., superior frontal gyrus), parietal (e.g., precuneus), temporal (e.g., inferior temporal gyrus), and occipital (e.g., cuneus) cortices. Furthermore, neural connectivity at the theta oscillation frequency was significant in these cortical regions during audiovisual object encoding compared with single modality object encoding. These results suggest that local oscillations and interregional connectivity via theta activity play an important role during audiovisual object encoding and may contribute to the formation of working memory traces from multisensory items.

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“…Hypoactivity may suggest that patients have a decreased level of arousal and attention to external stimuli, likely explaining the immersion of OCD patients in their own intrusive thoughts and repetitive behaviors (Chen et al, 2019 ). Additionally, the fusiform gyrus is an important region in the visual network (Muthukrishnan, Soni, & Sharma, 2020 ) and is implicated in the visual processing dysfunction associated with OCD (Lei et al, 2020 ). The decreased dALFF in the fusiform gyrus in the present study may be associated with visual deficits in OCD.…”

Section: Discussionmentioning

confidence: 99%

Temporal variability of regional intrinsic neural activity in drug‐naïve patients with obsessive–compulsive disorder

Liu

et al. 2021

Human Brain Mapping

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Obsessive-compulsive disorder (OCD) displays alterations in regional brain activity represented by the amplitude of low-frequency fluctuation (ALFF), but the time-varying characteristics of this local neural activity remain to be clarified. We aimed to investigate the dynamic changes of intrinsic brain activity in a relatively large sample of drug-naïve OCD patients using univariate and multivariate analyses. We applied a sliding-window approach to calculate the dynamic ALFF (dALFF) and compared the difference between 73 OCD patients and age-and sex-matched healthy controls (HCs). We also utilized multivariate pattern analysis to determine whether dALFF could differentiate OCD patients from HCs at the individual level. Compared with HCs, OCD patients exhibited increased dALFF mainly within regions of the cortical-striatal-thalamic-cortical (CSTC) circuit, including the bilateral dorsal anterior cingulate cortex, medial prefrontal cortex and striatum, and right dorsolateral prefrontal cortex (dlPFC). Decreased dALFF was identified in the bilateral inferior parietal lobule (IPL), posterior cingulate cortex, insula, fusiform gyrus, and cerebellum. Moreover, we found negative correlations between illness duration and dALFF values in the right IPL and between dALFF values in the left cerebellum and Hamilton Depression Scale scores. Furthermore, dALFF can distinguish OCD patients from HCs with the most discriminative regions located in the IPL, dlPFC, middle occipital gyrus, and cuneus.Taken together, in the current study, we demonstrated a characteristic pattern of higher variability of regional brain activity within the CSTC circuits and lower variability in regions outside the CSTC circuits in drug-naïve OCD patients. K E Y W O R D S dynamic amplitude of low-frequency fluctuation, multivariate pattern analysis, obsessivecompulsive disorder, resting-state fMRI Jing Liu and Xuan Bu contributed equally to this work.

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Brain Networks Communicate Through Theta Oscillations to Encode High Load in a Visuospatial Working Memory Task: An EEG Connectivity Study

Cited by 30 publications

References 98 publications

Voxel-Based Meta-Analysis of Gray Matter Abnormalities in Multiple System Atrophy

Voxel-Based Meta-Analysis of Gray Matter Abnormalities in Multiple System Atrophy

Theta Oscillations and Source Connectivity During Complex Audiovisual Object Encoding in Working Memory

Temporal variability of regional intrinsic neural activity in drug‐naïve patients with obsessive–compulsive disorder

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