Brain oxygenation with a non‐vasoactive perfluorocarbon emulsion in a rat model of traumatic brain injury

Abutarboush, Rania; Mullah, Saad Habib-E-Rasul; Saha, Banani; Haque, Ashraful; Walker, Peter B.; Aligbe, Chioma; Pappas, Georgina; Ho, Lam T.; Arnaud, Françoise; Auker, Charles R.; McCarron, Richard M.; Scultetus, Anke; Moon-Massat, Paula F.

doi:10.1111/micc.12441

Cited by 8 publications

(2 citation statements)

References 62 publications

(122 reference statements)

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“…For analysis of microvascular diameter changes, pial microvessels were grouped into either a ''small'' (<50 lm) or ''medium'' (50-100 lm) size category based on the pre-treatment baseline size. [28][29][30][31][32][33][34][35] The increase in the amount of smooth muscle with vessel size correlates with the ability of vessels to contract justifies dividing the vessels into size categories. 27 A power analysis of pilot data indicated that 40 vessels per size category were required to detect a 10% change in diameter with 80% power.…”

Section: Intravital Microscopy: Pial Arteriolar Reactivitymentioning

confidence: 99%

Exposure to Blast Overpressure Impairs Cerebral Microvascular Responses and Alters Vascular and Astrocytic Structure

Abutarboush

Kawoos

et al. 2019

Journal of Neurotrauma

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Exposure to blast overpressure may result in cerebrovascular impairment, including cerebral vasospasm. The mechanisms contributing to this vascular response are unclear. The aim of this study was to evaluate the relationship between blast and functional alterations of the cerebral microcirculation and to investigate potential underlying changes in vascular microstructure. Cerebrovascular responses were assessed in sham- and blast-exposed male rats at multiple time points from 2 h through 28 days after a single 130-kPa (18.9-psi) exposure. Pial microcirculation was assessed through a cranial window created in the parietal bone of anesthetized rats. Pial arteriolar reactivity was evaluated in vivo using hypercapnia, barium chloride, and serotonin. We found that exposure to blast leads to impairment of arteriolar reactivity >24 h after blast exposure, suggesting delayed injury mechanisms that are not simply attributed to direct mechanical deformation. Observed vascular impairment included a reduction in hypercapnia-induced vasodilation, increase in barium-induced constriction, and reversal of the serotonin effect from constriction to dilation. A reduction in vascular smooth muscle contractile proteins consistent with vascular wall proliferation was observed, as well as delayed reduction in nitric oxide synthase and increase in endothelin-1 B receptors, mainly in astrocytes. Collectively, the data show that exposure to blast results in delayed and prolonged alterations in cerebrovascular reactivity that are associated with changes in the microarchitecture of the vessel wall and astrocytes. These changes may contribute to long-term pathologies involving dysfunction of the neurovascular unit, including cerebral vasospasm.

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Section: Intravital Microscopy: Pial Arteriolar Reactivitymentioning

confidence: 99%

Exposure to Blast Overpressure Impairs Cerebral Microvascular Responses and Alters Vascular and Astrocytic Structure

Abutarboush

Kawoos

et al. 2019

Journal of Neurotrauma

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“…Perfluorocarbon with high affinity to oxygen has been demonstrated as promising O 2 shuttle to fight against hypoxic intratumor microenvironment so as to enhance the efficacy of some treatments such as RT and PDT. It is well known that PDT is strongly oxygen dependent because the PDT‐induced single oxygen ( 1 O 2 ) typically originates from oxygen molecules, which means that the therapeutic efficacy of PDT is substantially hindered by the tumor hypoxia .…”

Section: Oxygen (O2)‐generating Ggnsmentioning

confidence: 99%

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

2018

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The fast advances of theranostic nanomedicine enable the rational design and construction of diverse functional nanoplatforms for versatile biomedical applications, among which gas-generating nanoplatforms (GGNs) have emerged very recently as unique theranostic nanoplatforms for broad gas therapies. Here, the recent developments of the rational design and chemical construction of versatile GGNs for efficient gas therapies by either exogenous physical triggers or endogenous disease-environment responsiveness are reviewed. These gases involve some therapeutic gases that can directly change disease status, such as oxygen (O ), nitric oxide (NO), carbon monoxide (CO), hydrogen (H ), hydrogen sulfide (H S) and sulfur dioxide (SO ), and other gases such as carbon dioxide (CO ), dl-menthol (DLM), and gaseous perfluorocarbon (PFC) for supplementary assistance of the theranostic process. Abundant nanocarriers have been adopted for gas delivery into lesions, including poly(d,l-lactic-co-glycolic acid), micelles, silica/mesoporous silica, organosilica, MnO , graphene, Bi Se , upconversion nanoparticles, CaCO , etc. Especially, these GGNs have been successfully developed for versatile biomedical applications, including diagnostic imaging and therapeutic use. The biosafety issue, challenges faced, and future developments on the rational construction of GGNs are also discussed for further promotion of their clinical translation to benefit patients.

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Studies on the formation and stability of perfluorodecalin nanoemulsions by ultrasound emulsification using novel surfactant systems

Syed

Dias

Crespo

et al. 2021

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Brain oxygenation with a non‐vasoactive perfluorocarbon emulsion in a rat model of traumatic brain injury

Abstract: Although Oxycyte did not cause cerebral vasoconstriction, its use at the dose tested while breathing 100% O did not improve P O following TBI. However, Oxycyte treatment while breathing a lower enriched oxygen concentration may improve P O after TBI.

Cited by 8 publications

References 62 publications

Exposure to Blast Overpressure Impairs Cerebral Microvascular Responses and Alters Vascular and Astrocytic Structure

Exposure to Blast Overpressure Impairs Cerebral Microvascular Responses and Alters Vascular and Astrocytic Structure

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

Studies on the formation and stability of perfluorodecalin nanoemulsions by ultrasound emulsification using novel surfactant systems

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