Brain Perfusion Scintigraphy With Tc-99m Ethylcysteinate Dimer for Migraine Accompagnée

Merckx, Edouard; Schiepers, C; Verbruggen, A.; Janssens, Jules; Roo, M. De

doi:10.1097/00003072-199410000-00023

Clinical Nuclear Medicine

1994

DOI: 10.1097/00003072-199410000-00023

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Brain Perfusion Scintigraphy With Tc-99m Ethylcysteinate Dimer for Migraine Accompagnée

Edouard Merckx¹,

C Schiepers²,

A. Verbruggen³

et al.

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Cited by 4 publications

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“…3 Regional cerebral blood flow (rCBF) studies have been employed to investigate the pathophysiology of migraine headache. [6][7][8][9][10][11] Until now, no such reports of patients with ophthalmoplegic migraine have been reported. A number of studies examining rCBF in patients with migraine have been performed during prodromal or headache phases and using Tc 99m HMPAO or ECD SPECT.…”

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confidence: 99%

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Ophthalmoplegic Migraine With Reversible Thalamic Ischemia

2002

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Two patients who presented with ophthalmoplegic migraine underwent electroencephalography, brain magnetic resonance imaging, cerebral angiography, and technetium Tc 99m ethyl cysteinate dimer single photon emission computed tomography (SPECT) during an attack. Follow-up SPECT was performed after neurologic symptoms resolved. In both patients, SPECT during an attack of ophthalmoplegia and headache demonstrated significantly decreased regional cerebral blood flow (rCBF) in the thalamus on the side of the ophthalmoplegia; rCBF reverted to normal on a follow-up SPECT during the symptom-free period. These findings suggest reversible ischemia in the territories of perforating branches of the posterior cerebral artery may accompany ophthalmoplegic migraine and possibly bear some relationship to the clinical features.

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confidence: 99%

“…A number of studies examining rCBF in patients with migraine have been performed during prodromal or headache phases and using Tc 99m HMPAO or ECD SPECT. [6][7][8][9][10][11] Until now, no such reports of patients with ophthalmoplegic migraine have been reported.…”

mentioning

confidence: 99%

Ophthalmoplegic Migraine With Reversible Thalamic Ischemia

2002

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Preventive Treatment with Lomerizine Increases Cerebral Blood Flows during the Interictal Phase of Migraine

Ikeda

Aoyagi

Hanashiro

et al. 2018

Journal of Stroke and Cerebrovascular Diseases

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Alleviation of Brain Hypoperfusion after Preventative Treatment with Lomerizine in an Elderly Migraineur with Aura

Aoyagi¹,

Ikeda

Kiyozuka³

et al. 2011

International Journal of Molecular Imaging

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Previous studies of brain single-photon emission tomography (SPECT) showed changes of regional cerebral blood flow (rCBF) in migraineurs during prodromes or headache attacks. Little is known about how successful medication of migraine prevention can reflect rCBF in migraineurs. We highlighted alternation of brain SPECT findings in a migraineur with aura before and after prophylactic treatment with lomerizine, a calcium channel blocker. A 70-year-old man with migraine developed visual disturbance frequently at walking exercise for the recent 3 months. After this visual attack, a mild-degree of throbbing headache occured occasionally. Brain SPECT using 99mTc-ethyl cysteinate dimer was performed at interictal time of migraine. Brain SPECT before lomerizine treatment revealed hypoperfusion in the frontal, parietal, and occipital regions. He was diagnosed with recurrence of migraine with aura (MA). Lomerizine (10 mg/day, po) was administered for 3 months. MA and visual aura without headache were dramatically improved. Migraine attacks and visual disturbance were not induced at exercise. At 3 months after lomerizine medication, brain SPECT showed remarkable increase of rCBF. These SPECT changes of our patient indicated that antimigraine mechanism of lomerizine could contribute to restoration of cerebral hypoperfusion.

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Brain Perfusion Scintigraphy With Tc-99m Ethylcysteinate Dimer for Migraine Accompagnée

Cited by 4 publications

References 0 publications

Ophthalmoplegic Migraine With Reversible Thalamic Ischemia

Ophthalmoplegic Migraine With Reversible Thalamic Ischemia

Preventive Treatment with Lomerizine Increases Cerebral Blood Flows during the Interictal Phase of Migraine

Alleviation of Brain Hypoperfusion after Preventative Treatment with Lomerizine in an Elderly Migraineur with Aura

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