Brain state transitions primarily impact the spontaneous rate of slow-firing neurons

Dearnley, Bradley; Jones, Melissa; Dervinis, Martynas; Okun, Michael

doi:10.1016/j.celrep.2023.113185

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Cited by 3 publications

References 37 publications

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Evolution of pitchfork bifurcation in a tabu learning neuron model and its application in image encryption

Zhu,

Min,

Yang

et al. 2024

Chaos, Solitons & Fractals

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Evolution of pitchfork bifurcation in a tabu learning neuron model and its application in image encryption

Zhu,

Min,

Yang

et al. 2024

Chaos, Solitons & Fractals

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KETAMINE: Neural- and network-level changes

Bharmauria,

Ramezanpour,

Ouelhazi

et al. 2024

Neuroscience

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Cellular rules underlying psychedelic control of prefrontal pyramidal neurons

Ekins,

Brooks,

Kailasa

et al. 2023

Preprint

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Classical psychedelic drugs are thought to increase excitability of pyramidal cells in prefrontal cortex via activation of serotonin 2A receptors (5-HT2ARs). Here, we instead find that multiple classes of psychedelics dose-dependently suppress intrinsic excitability of pyramidal neurons, and that extracellular delivery of psychedelics decreases excitability significantly more than intracellular delivery. A previously unknown mechanism underlies this psychedelic drug action: enhancement of ubiquitously expressed potassium M-current channels that is independent of 5-HT2R activation. Using machine-learning-based data assimilation models, we show that M-current activation interacts with previously described mechanisms to dramatically reduce intrinsic excitability and shorten working memory timespan. Thus, psychedelic drugs suppress intrinsic excitability by modulating ion channels that are expressed throughout the brain, potentially triggering homeostatic adjustments that can contribute to widespread therapeutic benefits.

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Brain state transitions primarily impact the spontaneous rate of slow-firing neurons

Cited by 3 publications

References 37 publications

Evolution of pitchfork bifurcation in a tabu learning neuron model and its application in image encryption

Evolution of pitchfork bifurcation in a tabu learning neuron model and its application in image encryption

KETAMINE: Neural- and network-level changes

Cellular rules underlying psychedelic control of prefrontal pyramidal neurons

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