Brain stem glioma presenting as gastro-oesophageal reflux.

Mahony, Michael; Kennedy, J D; Leaf, Andrea; Matthew, D J; Milla, P J

doi:10.1136/adc.62.7.731

Cited by 10 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We tentatively diagnosed this patient with atypical Möbius syndrome ( Table 1), based on these considerations. The association of GERD and brainstem dysfunction in the present patients may be reminiscent of some cases with brainstem glioma [8,15,32], where GER was the initial manifestation of the dysfunction of the medulla oblongata.…”

Section: Discussionmentioning

confidence: 59%

“…Thus, the dysfunction of vago-vagal reflex through the medullary tegmentum can be regarded as an important factor, if not the sole factor, of dysphagia and GERD. These complications can be the initial or predominating symptom of brainstem lesions in patients with glioma [8,15,23] or Chiari malformations [23], similar to patient 4. We propose the term "dysphagia-GER complex" to describe the disturbed motility of the upper digestive tract due to brainstem dysfunction, particularly involving the NTSmediated reflex pathways.…”

Section: Discussionmentioning

confidence: 82%

See 1 more Smart Citation

Dysphagia-Gastroesophageal Reflux Complex: Complications Due to Dysfunction of Solitary Tract Nucleus-Mediated Vago-Vagal Reflex

et al. 2006

View full text Add to dashboard Cite

We report on the complication of gastroesophageal reflux (GER) in four patients with lower brainstem dysfunction. These patients suffered from perinatal asphyxia, cerebellar hemorrhage, or congenital dysphagia of unknown origin and showed facial nerve palsy, inspiratory stridor due to vocal cord paralysis, central sleep apnea, and dysphagia, in various combinations. Naso-intestinal tube feeding was introduced in all of the patients due to recurrent vomiting and aspiration pneumonia resulting from GER. T2-weighted magnetic resonance (MR) imaging revealed symmetrical high intensity lesions in the tegmentum of the lower pons and the medulla oblongata in two of the patients, and pontomedullary atrophy in another patient. In normal subjects, lower esophageal sphincter contraction is provoked by distension of the gastric wall, through a vago-vagal reflex. Since this reflex arc involves the solitary tract nucleus, where the swallowing center is located, the association of dysphagia and GER in the present patients is thought to result from the lesions in the tegmentum of medulla oblongata. We propose the term "dysphagia-GER complex" to describe the disturbed motility of the upper digestive tract due to lower brainstem involvement. In children with brainstem lesions, neurological assessment of GER is warranted, in addition to the examination of other signs of brainstem dysfunction, including dysphagia and respiratory disturbance.

show abstract

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 82%

Dysphagia-Gastroesophageal Reflux Complex: Complications Due to Dysfunction of Solitary Tract Nucleus-Mediated Vago-Vagal Reflex

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Similar reported cases indicate these infiltrating and often slowly growing tumors disrupt motility of the upper gastrointestinal tract [3,[6][7][8][11][12][13].…”

Section: Pathophysiology Of the Gastrointestinal Disturbancementioning

confidence: 71%

“…We must, nevertheless, assume that tumor was present at that time. Notwithstanding reports like that of Bilaniuk et al [3] which noted the 96% accuracy of the CT scan in detecting brain stem lesions, Mahoney et al [7] found that CT studies tended to remain nega tive for periods varying from 6 months to 2 years from the time of symptom onset. Certainly, improvement in newer generation CT scanners and the larger size of the tumor 7 years later made the diagnosis readily apparent.…”

Section: Neurodiagnostic Assessmentmentioning

confidence: 88%

“…The cell bodies of the nucleus ambiguus are responsible for the innervation of the striated muscles of the prox imal and middle one-third of the esophagus, while the cells bodies in the dorsal motor nucleus of the tenth nerve innervate the smooth muscles of the middle and distal one-third. Both animal and clinical studies in hu mans indicate that lesions of these nuclei may result in esophageal dysmotility and gastroesophageal reflux [5,7,15].…”

Section: Pathophysiology Of the Gastrointestinal Disturbancementioning

confidence: 99%

See 1 more Smart Citation

Chronic Dysphagia, Vomiting and Gastroesophageal Reflux as Manifestations of a Brain Stem Glioma: A Case Report

Frank

et al. 1989

Pediatr Neurosurg

View full text Add to dashboard Cite

Brain stem glioma is the third most common childhood brain tumor, comprising 10–15% of this group of neoplasms. Typical presenting symptoms include ataxia, diplopia and headache, while signs of increased intracranial pressure occur later in the clinical course. Although prolonged failure to thrive, characterized by cachexia and vomiting are rare manifestations of brain stem lesions, in this study we report a 9.5-year-old boy with failure to thrive since infancy which remitted after excision of a brain stem astrocytoma.

show abstract

Functional Basis of Posterior Fossa Tumor Symptoms and Signs

Pascual-Castroviejo¹

1993

Posterior Fossa Tumors

View full text Add to dashboard Cite

Brain stem glioma presenting as gastro-oesophageal reflux.

Cited by 10 publications

References 6 publications

Dysphagia-Gastroesophageal Reflux Complex: Complications Due to Dysfunction of Solitary Tract Nucleus-Mediated Vago-Vagal Reflex

Dysphagia-Gastroesophageal Reflux Complex: Complications Due to Dysfunction of Solitary Tract Nucleus-Mediated Vago-Vagal Reflex

Chronic Dysphagia, Vomiting and Gastroesophageal Reflux as Manifestations of a Brain Stem Glioma: A Case Report

Functional Basis of Posterior Fossa Tumor Symptoms and Signs

Contact Info

Product

Resources

About