Brain Tuberculomas: A Case Report

Saleh, Maryam; Saeedi, Ali Asghar; Pooran, Ali Ali

doi:10.5812/jjm.11252

Cited by 26 publications

(32 citation statements)

References 10 publications

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“…We ruled out an infectious aneurysm using MRA, narrowing the differential diagnosis to infectious granuloma and cold abscess. In patients with cryptococcoma, antifungal treatment is continued until the lesion has resolved on MRI (7). Therefore, we continued antibiotic therapy and determined the therapeutic duration for the treatment of meningitis based on the MRI findings.…”

Section: Discussionmentioning

confidence: 99%

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Bacterial Meningitis Caused by Hypervirulent <i>Klebsiella pneumoniae</i> Capsular Genotype K54 with Development of Granuloma-like Nodal Enhancement in the Brain during the Subacute Phase

et al. 2017

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A 72-year-old man was admitted to the emergency department due to coma. The cerebrospinal fluid cell count was 40,080 cells/μL, and Klebsiella pneumoniae was detected on culture. Stretching the bacterial colonies on an agar plate showed the formation of a viscous string with a length exceeding 5 mm, indicating hypervirulent K. pneumoniae (hv-KP). A genome analysis suggested hv-KP capsular genotype K54 with sequence type 29. Although no brain abscess was detected on contrast-enhanced computed tomography on Day 4 or on magnetic resonance imaging (MRI) on Day 7, contrast-enhanced MRI on Day 23 showed granuloma-like nodal enhancement on the surface of the left insula. Antibacterial therapy was continued until the enhancement disappeared on Day 40. MRI may help determine the duration required for antibacterial therapy. After six months, the patient was discharged and remained free from recurrence.

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Section: Discussionmentioning

confidence: 99%

“…Although previous case reports have shown that classic KP meningitis cases have unusual brain radiological findings (4-6), nodal enhancement similar to cryptococcoma or tuberculoma is extremely rare (7,8). We herein report a case of hv-KPM with granuloma-like nodal enhancement in the brain during the subacute phase.…”

Section: Introductionmentioning

confidence: 94%

Bacterial Meningitis Caused by Hypervirulent <i>Klebsiella pneumoniae</i> Capsular Genotype K54 with Development of Granuloma-like Nodal Enhancement in the Brain during the Subacute Phase

et al. 2017

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“…İntrakranyal tüberkülomanın tedavi süresi en az bir yıl olmalıdır (7). Bazı yazarlar iki yıla kadar uzatılmasını ve en az üç yıl boyunca hastanın nörolojik semptomlar açı-sından izlenmesini önermişlerdir (12). Biz de olgumuzda menenjit bulguları ve nörolojik defisit gelişmesi nedeniyle kısa süreli steroid tedavisi uyguladık.…”

Section: Discussionunclassified

A case of miliary tuberculosis accompanied by central nervous system involvement

Demir¹,

Taylan²,

Arslan³

et al. 2016

Respir Case Rep

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“…Vacuum pump removal of any unreacted thionyl chloride is recommended. Add 400 microliter of anhydrous NH 2 NH 2 and microwave at 45 second intervals up to five minutes (avoid excess heating during the process) [17]. Excess hydrazine was removed by vacuum pump at room temperature or alternatively the product is washed several times in ice-cold diethyl ether.…”

Section: Synthesis Of Compoundsmentioning

confidence: 99%

Aromatic Hydrazide Compounds That Inhibit the Growth of Mycobacterium tuberculosis

Bartzatt

Sule

Galbadage

et al. 2020

JAMPS

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Aims: To demonstrate the efficacy of aromatic hydrazide compounds to inhibit growth of Mycobacterium tuberculosis. Study Design: To synthesize tuberculostats and test their antibacterial activity in-vitro. Place and Duration of Study: University of Nebraska, Durham Science Center, 6001 Dodge Street, Omaha NE 68182, and Texas A&M Health Science Center, Department of Microbial Pathogenesis and Immunology, 8447 State Hwy 47, Medical Research and Education Building, Room #3012, Bryan, TX 7780. From March 2019 to October 2019. Methodology: Hydrazide functional groups were formed by covalently bonding hydrazine onto a carbonyl carbon that is a substituent of a single aromatic ring. Microwave excitation was utilized for synthesis, followed by evaluation of antibacterial activity. These compounds were placed into tissue culture media at various concentrations and then Mycobacterium tuberculosis bacteria was added, in order to determine the level of growth inhibition. Growth inhibition of the bacteria was measured as a function of compound concentration versus growth inhibition. Results: Compounds A, B, C, and D carry hydrazide groups as a substituent to a single aromatic ring. All four compounds show zero violations of Rule of 5, indicating favorable drug-likeness. All four compounds showed greater than 50% growth inhibition of bacteria at concentrations below 50 micrograms per milliliter. Growth inhibition was measured by colony forming units and luminescence. Polar surface area, Log P, molecular volume, and other molecular properties were determined for these four compounds. Conclusion: These four hydrazide compounds induced substantial inhibition of bacterial growth. Microwave excitation for the synthesis of hydrazide compounds is effective. These compounds have favorable drug-likeness properties and are highly effective inhibiting the growth of Mycobacterium tuberculosis.

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Brain Tuberculomas: A Case Report

Cited by 26 publications

References 10 publications

Bacterial Meningitis Caused by Hypervirulent <i>Klebsiella pneumoniae</i> Capsular Genotype K54 with Development of Granuloma-like Nodal Enhancement in the Brain during the Subacute Phase

Bacterial Meningitis Caused by Hypervirulent <i>Klebsiella pneumoniae</i> Capsular Genotype K54 with Development of Granuloma-like Nodal Enhancement in the Brain during the Subacute Phase

A case of miliary tuberculosis accompanied by central nervous system involvement

Aromatic Hydrazide Compounds That Inhibit the Growth of Mycobacterium tuberculosis

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