Brainin A, a novel flavanol from Brainea insignis

Yang, Ming; Cai, Le; Tai, Zhi Gang; Yang, Xue; Ding, Zhong Tao

doi:10.1016/j.cclet.2010.11.009

Cited by 5 publications

(5 citation statements)

References 7 publications

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“…As shown in Figure 2 , 1 H- 1 H COSY data showed correlations between H-3/H-2, and H-2/H-4, indicating that the three methine protons were connected. The above data suggested that compound 1 was a flavanol derivative [ 37 – 40 ]. The 1 H- 1 H COSY spectrum also displayed a correlation between H-4 and H-11, and the heteronuclear multiple-bond connectivity (HMBC) spectrum displayed correlations of H-4 ( δ H 2.54) with C-11 ( δ C 34.1), C-12 ( δ C 98.8) and H-11 ( δ H 1.29 and 2.13) with C-3 ( δ C 69.2), C-4 ( δ C 25.6).…”

Section: Resultsmentioning

confidence: 99%

“…There were 10 degrees of unsaturation evident in the molecule of 1, of which nine were represented by flavanol and one unsaturation was left. The chemical shift of C-5 was shifted downfield by 5.4 ppm, compared with carbon atom in (-)-epicatechin [ 40 ], indicating that the ether was incorporated between C-5 and C-12 [ 37 – 39 ]. Moreover, the HMBC correlations of C-12 with H-11, H-13, and H-14, indicated that the methyl group and methoxy group were attached to C-12.…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Figure 2, 1 H-1 H COSY data showed correlations between H-3/H-2, and H-2/H-4, indicating that the three methine protons were connected. The above data suggested that compound 1 was a flavanol derivative [37][38][39][40]. The [40], indicating that the ether was incorporated between C-5 and C-12 [37][38][39].…”

mentioning

confidence: 99%

“…The above data suggested that compound 1 was a flavanol derivative [37][38][39][40]. The [40], indicating that the ether was incorporated between C-5 and C-12 [37][38][39]. Moreover, the HMBC correlations of C-12 with H-11, H-13, and H-14, indicated that the methyl group and methoxy group were attached to C-12.…”

mentioning

confidence: 99%

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Antioxidant, Anti‐Inflammatory, and Antidiabetic Activities of Bioactive Compounds from the Fruits of Livistona chinensis Based on Network Pharmacology Prediction

Wang

Zhai

Yang

et al. 2021

Oxidative Medicine and Cellular Longevity

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In this study, a chemical investigation on the fruits of Livistona chinensis (FLC) led to the isolation and identification of 45 polyphenols and 5 alkaloids, including two new compounds (Livischinol (1) and Livischinine A (46)), an undescribed compound (47) and 47 known compounds. FLC was predicted with novel potential antidiabetic function by collecting and analyzing the potential targets of the ingredients. Compound 32 exhibited significant α-glucosidase inhibitory activity ( I C 50 = 5.71 μM) and 1, 6, and 44 showed the PTP1B inhibitory activity with IC50 values of 9.41-22.19 μM, while that of oleanolic acid was 28.58 μM. The competitive inhibitors of PTP1B (compounds 1 and 44) formed strong binding affinity, with catalytic active sites, proved by kinetic analysis, fluorescence spectra measurements, and computational simulations, and stimulated glucose uptake in the insulin-resistant HepG2 cells at the dose of 50 μM. In addition, FLC was rich in antioxidant and anti-inflammatory bioactive compounds so that they could be developed as nutraceuticals against diabetes.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…As shown in Figure 2, 1 H-1 H COSY data showed correlations between H-3/H-2, and H-2/H-4, indicating that the three methine protons were connected. The above data suggested that compound 1 was a flavanol derivative [37][38][39][40]. The [40], indicating that the ether was incorporated between C-5 and C-12 [37][38][39].…”

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Antioxidant, Anti‐Inflammatory, and Antidiabetic Activities of Bioactive Compounds from the Fruits of Livistona chinensis Based on Network Pharmacology Prediction

Wang

Zhai

Yang

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…The mechanism about uprooting of cassava root is complex. It is difficult to get the interaction between cassava root and soil and the changing process of root's stress by physical tests [1][2]. SPH method is a kind of typical meshless Lagrange numerical method.…”

Section: Introductionmentioning

confidence: 99%

Numerical Simulation of Uprooting of Cassava Root

Wang

Cai

Yang

et al. 2012

AMM

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Based on the methods including modified Mohr-Coulomb yield criterion, Lagrange and smoothed particle hydrodynamics (SPH), the cassava stem - root - soil system dynamics simulation model is established by ANSYS/ LS-DYNA. The interaction mechanisms between uprooted cassava root and soil are discovered. The processes of soil shearing and the changing processes of root's stress are analyzed. The studies show that (1) the effects of root being extruded on the soil expand gradually from inside to outside in the process of uprooting, and the uprooted force reaches the maximum value when the soil appears ring shear rupture; (2) after the uprooted force reaches the maximum value, the root's effective stress still increases gradually with the increasing of its bending deformation until the soil is separated,and root's maximum effective stress appears in the combination of the root and stem where is the most easily to be broken;(3)when the maximum uprooted force on cassava root is analyzed, the interaction of a disc and its extension on the soil is regarded as the mechanical model of maximum uprooted force on cassava root.

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