Brazilian Green Propolis Compared to Miconazole Gel in the Treatment ofCandida-Associated Denture Stomatitis

Abstract

Aim. To evaluate the efficacy of Brazilian green propolis in comparison to miconazole gel in the treatment of Candida-associated denture stomatitis. Methods. Forty-five denture stomatitis patients, with palatal mucosa erythema levels classified according to Newtons's criteria and with positive culture to Candida spp., were randomly divided into three treatment groups: 15 received miconazole gel 2%, 15 received propolis gel 2,5%, and 15 received propolis 24% for mouthwash. After four daily use lasting two weeks, they were reexamined for the denture stomatitis degree and for a second culture of Candida. The Wilcoxon's test was applied to compare the results of clinical classification of the denture stomatitis and the Candida spp. colonies numbers, before and after each treatment. The Kruskall-Wallis's test was used to compare efficacy among the three treatment groups. Results. There were a significant reduction or complete remission of denture stomatitis (P < 0.05) and a significant decrease of Candida colonies for the three groups (P < 0.05). There was no difference in the efficacy among the treatment groups (P > 0.05). Conclusion. Brazilian green propolis has a similar effect as miconazole in the treatment of Candida-associated denture stomatitis being an alternative in the therapeutics of this condition.

Essential Oils, Silver Nanoparticles and Propolis as Alternative Agents Against Fluconazole Resistant Candida albicans, Candida glabrata and Candida krusei Clinical Isolates

“…It contains resinous substances collected by honey bees, from various plants, thus forming a complex of biologically active substances [16]. Several research groups revealed high antifungal potential of propolis against Candida clinical isolates [26][27][28][29]. The results of our investigation confirmed high fungicidal activity of propolis against all strains tested, but only in the case of one of four analyzed samples.…”

Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial

“…Therefore, it may be questioned whether the treatment duration or use of higher concentrations could interfere with the antifungal action. Capistrano et al [19] obtained clinical improvement in prosthetic stomatitis lesions, but without total remission of the lesions in all patients, in a study with a methodology similar to the present study.…”

“…In vitro models showed that the 1% alcoholic propolis extract was sufficient to completely inhibit the growth of one million Candida cells per millilitre of sample [22]. The efficacy of propolis gel was demonstrated and compared to the use of miconazole oral gel in clinical studies [19, 23]. …”

Interventions for the Management of Denture Stomatitis: A Systematic Review and Meta‐Analysis

“…Four studies pooled to evaluate the effect of imidazole on clinical stomatitis found no effect on the remission of clinical stomatitis (RR = 0.98, 95% CI = 0.85–1.13). There was no heterogeneity ( P = .26; I 2 = 26%), and no effect was found for mycological assessment (RR = 0.77, 95% CI = 0.56–1.07; P = .96, I 2 = 0%).…”