“…Bacillus coagulans is a gram‐positive rod‐shaped spore‐forming bacterium with a safe and effective history of use as a probiotic for human consumption. Due to its high tolerance to extreme environments and bioactive characteristics, B. coagulans has recently caught the interests of researchers (Almada‐Érix et al, 2022; Cao et al, 2020). Several beneficial effects of B. coagulans have been reported: first, B. coagulans can produce a variety of enzymes, such as β‐galactosidase, α‐galactosidase, α‐amylase, lipase, alkaline protease, and so on, to decompose dietary fiber, protein, and other large molecules into small molecules to increase intestinal absorption and utilization of nutrients (Batra et al, 2022); second, B. coagulans can regulate the microecological balance of digestive tract and inhibit the growth of pathogenic bacteria (Jiang et al, 2022); last, due to its ability to normalize both the quantitative parameters of the immune system and functional activity of immune cells, B. coagulans can significantly benefit the host immune system (Bomko et al, 2017).…”