Breakable mesoporous silica nanoparticles for targeted drug delivery

Maggini, Laura; Cabrera, Ingrid; Ruiz‐Carretero, Amparo; Prasetyanto, Eko Adi; Robinet, Éric; Cola, Luisa De

doi:10.1039/c5nr09112h

Cited by 196 publications

(142 citation statements)

References 49 publications

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“…The semi-transparency of biological tissue in the window 700-1000 nm makes this range particularly appealing for optical probes of analytes with absorption (and/or luminescence) in this range, as well as for photothermal and photodynamic therapeutic applications which may rely on photo-activation of particular drugs (e.g. to open cages containing suitable drugs in place of "redox-driven" breaking mechanisms), [15] or for therapy of sensitive tumours, [16] or even atherosclerosis treatment. [17] NIR LEDs are often used also in security authentication technologies exploiting biometrics, such as imaging of finger veins [18] and iris recognition.…”

Section: Opportunities and Challenges 21 Application Areas Of Nir Emmentioning

confidence: 99%

Near‐Infrared (NIR) Organic Light‐Emitting Diodes (OLEDs): Challenges and Opportunities

Zampetti

Minotto

Cacialli

2019

Adv Funct Materials

458

270

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The rapid development of the science and technology of organic semiconductors has already led to mass application of organic light‐emitting diodes (OLEDs) in television monitors of outstanding quality as well as in a large variety of smaller displays found in smartphones, tablets, and other gadgets, while introduction of the technology to the illumination sector is imminent. Notably, the requirements of all such applications for emission in the visible range of the electromagnetic spectrum are well tuned to the optical and electronic properties of typical organic semiconductors, thereby representing relatively “low‐hanging fruits,” in terms of material development and exploitation. However, the question arises as to whether developing materials suited for efficient near‐infrared (NIR, 700–1000 nm) emission is possible, and, crucially, desirable to enable new classes of applications spanning from through‐space, short‐range communications to biomedical sensors, night vision, and more generally security applications to name but a few. Here, the major fundamental hurdles to be overcome to achieve efficient NIR emission from organic π‐conjugated systems are discussed, recent progress is reviewed, and an outlook for further development of both materials and applications is provided.

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Section: Opportunities and Challenges 21 Application Areas Of Nir Emmentioning

confidence: 99%

Near‐Infrared (NIR) Organic Light‐Emitting Diodes (OLEDs): Challenges and Opportunities

Zampetti

Minotto

Cacialli

2019

Adv Funct Materials

458

270

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“…356 Some work has been done to ease the degradation 357 of nanoparticles once they have performed their 358 function. Maggini et al [58] recently reported 359 breakable MSNs by introducing redox-cleavable 360 disulphide bonds inside the silica network that 361 induced the loss of particle structure when exposed 362 to a reducing environment (like the intracellular 363 medium). This particle self-destruction would then 364 facilitate the degradation and excretion of the 365 resulting smaller particles.…”

Section: Chemical Compositionmentioning

confidence: 99%

Tuning mesoporous silica dissolution in physiological environments: a review

et al. 2017

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19Matrix degradation has a major impact on the release kinetics of drug delivery 20 systems. Regarding ordered mesoporous silica materials for biomedical appli-21 cations, their dissolution is an important parameter that should be taken into 22 consideration. In this paper, we review the main factors that govern the 23 mesoporous silica dissolution in physiological environments. We also provide 24 the necessary knowledge to researchers in the area for tuning the dissolution 25 rate of those matrices, so the degradation could be controlled and the material 26 behaviour optimised. 27 28 29 Introduction 30 Ordered mesoporous silica materials (OMS) have 31 received great attention by the biomedical scientific 32 community since they were proposed for the first 33 time as drug delivery systems by the research group 34 headed by Vallet-Regí et al. [1]. Their unique struc-35 tural and textural properties, such as tuneable pore 36 structure, large surface area and pore volume, con-37 trollable pore diameter and morphology, and func-38 tionalisable surface, make OMS excellent candidates 39 to be applied as drug delivery devices in different 40 biomedical applications [2][3][4][5]. 41Initially, OMS were purposed as bioceramics for 42 local drug delivery and bone tissue regenerations due 43 to their surface characteristics, such as biocompati-44 bility and bioactivity, and their capability to load and 45 release in a controlled fashion different therapeutic 46 cargoes for the treatment of diverse pathologies 47 (Fig. 1,t o (Fig. 1, bottom), 56 underlining their systemic administration as 57 nanocarriers for diagnosis and treatment of complex 58 diseases such as cancer [20][21][22][23][24][25]. 59 The degradability of different drug delivery devi-60 ces is a key parameter for their successful translation 61 to a clinical scenario. In this sense, dissolution has 62 profound implications in the mechanical properties 63 of materials used for bone filling. Most importantly,

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“…Gene transfection efficiency is affected by both the level of cellular uptake and the ability to escape from endosomal compartments . Colocalization studies were conducted to investigate the distribution of Gal‐micelles inside the cells using the Z‐stack technique . Phalloidin Alexa Fluor 647 and LysoTracker Deep Red were used to stain cytoskeleton and acidic organelles, respectively.…”

Section: Resultsmentioning

confidence: 99%

An Integrated Therapeutic Delivery System for Enhanced Treatment of Hepatocellular Carcinoma

Zhou

Qin

et al. 2018

Adv Funct Materials

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Nanomaterials hold promise for the treatment of human carcinomas but integrating multiple functions into a single drug carrier system remains challenging. Herein, an integrated therapeutic delivery system for human hepatocellular carcinoma (HCC) treatment is reported, which is based on rhodamine B (RhB) end-labeled cationic poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) and hydrophobic poly(3-azido-2-hydroxypropyl methacrylate) (PGMA-N 3 ) segments equipped with a covalently bound galactose. This biocompatible and safe platform RhB-PDMAEMA25-c-PGMA50-Gal micelles (Gal-micelles) offers four advantages: (1) Galactose ligands enhance cellular uptake by targeting the asialoglycoprotein receptor (ASGPR) that is overexpressed on HCC cell lines surfaces; (2) RhB end-labeling facilitates real-time imaging for tracking both in vitro and in vivo;(3) the acidic tumor microenvironment protonates the carrier system for efficient drug release as well as gene transfection, (4) codelivery of anticancer drug doxorubicin (DOX) and B-cell lymphoma 2 small interfering RNA (Bcl-2 siRNA) works synergistically against tumor growth in both subcutaneous and orthotopic HCC bearing mouse models. This integrated therapeutic delivery system holds potential for future clinical HCC treatment.

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Breakable mesoporous silica nanoparticles for targeted drug delivery

Cited by 196 publications

References 49 publications

Near‐Infrared (NIR) Organic Light‐Emitting Diodes (OLEDs): Challenges and Opportunities

Near‐Infrared (NIR) Organic Light‐Emitting Diodes (OLEDs): Challenges and Opportunities

Tuning mesoporous silica dissolution in physiological environments: a review

An Integrated Therapeutic Delivery System for Enhanced Treatment of Hepatocellular Carcinoma

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