Breaking Bad: Uncoupling of Modularity in Centriole Biogenesis and the Generation of Excess Centrioles in Cancer

Fisk, Harold A.; Thomas, Jessica; Nguyen, Thu T.

doi:10.1007/978-3-030-23173-6_17

Cited by 3 publications

(1 citation statement)

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“…AgNPs also affect cellular components (CC), including extracellular exosome, cytoplasm, and centriole-related proteins. Centriole is a cell structure that is involved in cell cycle regulation, including colorectal cancer [ 20 , 21 ]. Alternatively, the molecular function (MF) affected by exposure to AgNPs were cadherin and RNA binding, which plays an important role in the development of CRC [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Bioinformatic Analysis of the Effect of Silver Nanoparticles on Colorectal Cancer Cell Line

Gutiérrez-Angulo

Becerra-Ruiz

Pérez

et al. 2022

BioMed Research International

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Colorectal cancer (CRC) is the most diagnosed cancer with the highest mortality rate each year globally. Although there are treatments for CRC, the development of resistance to therapies decreases the success of treatments. In vitro studies using the Caco-2 cell line have revealed the anticancer properties of silver nanoparticles (AgNPs) as a possible treatment for this disease. This study considered four researches that evaluated the proteomic profiles of cells of the Caco-2 line exposed to AgNPs. We performed a bioinformatics analysis to predict protein-protein interaction, hub genes, Gene Ontology (molecular function, biological process, and cellular components), KEGG pathways, analysis of expression, and immune cell infiltration. For these analyses, the STRING, DAVID, UALCAN, GEPIA2, and TISIDB databases were used. The results in Gene Ontology show that AgNPs cause a deregulation of genes related to cell-cell adhesion, the cytoplasm, the centriole, and carbon metabolism. Hub genes were identified, including GADPH, ENO1, EEF2, and ATP5A1, which showed differential expression in patients with adenocarcinoma of the colon and rectum. Additionally, the expression of the hub genes and immune cells was correlated. It was found that ATP5A1 and ENO1 were positively correlated with the infiltration of CD4+ T lymphocytes in colon adenocarcinoma and a negative correlation between GADPH and PDIA3 with the infiltration of NK cells and CD4+ T lymphocytes in rectal adenocarcinoma, respectively. In conclusion, the administration of AgNPs causes an alteration of biological processes, cellular components, metabolic pathways, deregulation of hub genes, and the activity of immune cells leading to a potential anticancer effect.

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Section: Discussionmentioning

confidence: 99%

Bioinformatic Analysis of the Effect of Silver Nanoparticles on Colorectal Cancer Cell Line

Gutiérrez-Angulo

Becerra-Ruiz

Pérez

et al. 2022

BioMed Research International

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Kinase-anchoring proteins in ciliary signal transduction

Gopalan

Wordeman

Scott

2021

Biochemical Journal

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Historically, the diffusion of chemical signals through the cell was thought to occur within a cytoplasmic soup bounded by the plasma membrane. This theory was predicated on the notion that all regulatory enzymes are soluble and moved with a Brownian motion. Although enzyme compartmentalization was initially rebuffed by biochemists as a ‘last refuge of a scoundrel', signal relay through macromolecular complexes is now accepted as a fundamental tenet of the burgeoning field of spatial biology. A-Kinase anchoring proteins (AKAPs) are prototypic enzyme-organizing elements that position clusters of regulatory proteins at defined subcellular locations. In parallel, the primary cilium has gained recognition as a subcellular mechanosensory organelle that amplifies second messenger signals pertaining to metazoan development. This article highlights advances in our understanding of AKAP signaling within the primary cilium and how defective ciliary function contributes to an increasing number of diseases known as ciliopathies.

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Expression of cell cycle genes among the residents of settlements along the Techa River exposed to ionizing radiation <i>in utero</i>

Nikiforov,

Blinova,

Akleyev

2024

Ekologiya cheloveka (Human Ecology)

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Abstract BACKGROUND: The intrauterine period of development of the body is the most sensitive to the action of ionizing radiation. Although the effects of prenatal radiation exposure remain poorly understood, it is assumed that antenatal irradiated organisms constitute a risk group for the development of long-term somatic-stochastic effects of radiation exposure. AIM: The aim of this study was to analyze the expression of mRNA of cell cycle genes (TP53, MDM2, CDKN1a, ATM) in the long-term in individuals exposed to chronic radiation exposure on the Teche River during intrauterine development. METHODS: The study was conducted more than 60 years after the onset of chronic radiation exposure in 170 people. Of these, 54 people were exposed in the prenatal and postnatal periods of development, 80 people were exposed to chronic radiation after birth. The comparison group included 36 people living in similar socio-economic conditions, with an accumulated dose of red bone marrow radiation not exceeding 70 mGr for the entire period of life. RESULTS: It has been shown that in the long-term period, residents of the coastal villages of the Techa River, exposed during the periods of antenatal and postnatal development, there is a decrease in the relative mRNA content of the MDM2 and CDKN1a genes compared to the comparison group and people whose chronic radiation exposure occurred after birth. The results of the correlation analysis indicate that there is no dependence of changes in the mRNA expression of the studied genes on the amount of accumulated absorbed dose of intrauterine and postnatal exposure of red bone marrow in the examined people. CONCLUSION: It can be assumed that a decrease in the transcriptional activity of the MDM2 and CDKN1a genes in persons exposed to chronic radiation exposure in the prenatal period may play a role in the development of long-term effects of radiation exposure in humans.

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Breaking Bad: Uncoupling of Modularity in Centriole Biogenesis and the Generation of Excess Centrioles in Cancer

Cited by 3 publications

References 103 publications

Bioinformatic Analysis of the Effect of Silver Nanoparticles on Colorectal Cancer Cell Line

Bioinformatic Analysis of the Effect of Silver Nanoparticles on Colorectal Cancer Cell Line

Kinase-anchoring proteins in ciliary signal transduction

Expression of cell cycle genes among the residents of settlements along the Techa River exposed to ionizing radiation <i>in utero</i>

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