This investigation was carried out during two seasons 2017 and 2018 on Flame seedless and superior seedless (Vitis vinifera L.) grapevines ten years old, grown in a private vineyard located at El-Beheira Governorate. The study was conducted to evaluate the potential effects of spraying with some natural substances (Garlic extract at 10 and 15% as well as Clove oil at 7 and 10%) as compared to artificial chemical treatment (Hydrogen cyanamide at 2.5%) usually used for breaking bud dormancy. The treatments were applied alone or combined with mineral oil at 2% two times (first week of January and one week later) in both seasons. The obtained results cleared that, the natural substances used, especially Garlic extract at 10 or 15% + mineral oil at 2% are resemble with Hydrogen cyanamide alone or with mineral oil at 2% treatment in hastening bud sprouting, shortening the duration of bud break, enhancing fertility coefficient, improving yield, cluster quality parameters (weight, length and width and berries per cluster), berries physical (weight, dimensions, volume) and chemical (SSC, SSC/acid ratio and anthocyanin contents of Flame seedless) quality parameters of both grapevine cvs. over control. Alternatively, Garlic extract can be used to safety release buds instead of that artificial chemical such as Hydrogen cyanamide.