This study evaluated the individual and psychosocial impacts of personal protective equipment on firefighters by conducting a systematic review and meta-analysis. While PPE is necessary for the protection of firefighters, it can also lead to a number of challenges, which may be both physical and psychological. This assessment incorporates insights from several studies that discuss the factors of stress related to the use of PPE by firefighters. The key aspects of the assessment include the adverse effects of overheating, the restriction of free movements, the inability to speak normally, and various other factors that increase stress. Studies have revealed that the use of PPE increases physical and mental stress levels by 10–25%, which increases overall anxiety by 35% and stress levels by 20–30%. The results suggest that the use of PPE is correlated with heightened levels of both physical and mental stress, leading to a 35% increase in anxiety and a 20–30% increase in stress. This study highlights the need to adopt a multidisciplinary approach to address and reduce the effects of PPE use on stress. Policy directions are aimed at improving PPE design, applying stress prevention programs, and controlling organizational strategies to protect firefighters’ safety and well-being.