Breaking Iron Homeostasis: Iron Capturing Nanocomposites for Combating Bacterial Biofilm
Wenyue Sun,
Jiao Sun,
Qihang Ding
et al.
Abstract:Given the scarcity of novel antibiotics, the eradication of bacterial biofilm infections poses formidable challenges. Upon bacterial infection, the host restricts Fe ions, which are crucial for bacterial growth and maintenance. Having coevolved with the host, bacteria developed adaptive pathways like the hemin‐uptake system to avoid iron deficiency. Inspired by this, we propose a novel strategy, termed iron nutritional immunity therapy (INIT), utilizing Ga‐CT@P nanocomposites constructed with gallium, copper‐d… Show more
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