Breakthrough mucormycosis after voriconazole use in a case of invasive fungal rhinosinusitis due to &lt;i&gt;Curvularia lunata &lt;/i&gt;

Gupta, Nitin; Kumar, Arvind; Singh, Gagandeep; Ratnakar, Gogineni; Vinod, Kutty Sharada; Wig, Naveet

doi:10.5582/ddt.2017.01060

Cited by 11 publications

(6 citation statements)

References 10 publications

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“…In a patient with ROCM, polymerase chain reaction (PCR) facilitated the diagnostic process. In one case, it was assumed that the patient had aspergillosis; however, panfungal PCR assay identified mucormycosis as the cause of the infection and pointed to the right treatment 61 . Therefore, the use of molecular‐based assays can help to detect different Mucor species and it can be recommended as a valuable add on tool that complements conventional diagnostic procedures; however, the efficiency of molecular‐based diagnosis requires a thorough clinical evaluation and has not been widely confirmed; therefore, it cannot be recommended as a standalone, single approach to clinical routine diagnostics 59 .…”

Section: Discussionmentioning

confidence: 99%

Epidemiology, clinical features, diagnosis and treatment of cerebral mucormycosis in diabetic patients: A systematic review of case reports and case series

Chegini

Didehdar

Khoshbayan

et al. 2020

Mycoses

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Summary Background Patients with diabetes are known as an important high‐risk group for cerebral mucormycosis (CM). Method We conducted a structured search using PubMed/MEDLINE to collect both case reports and case series case (ie including at least two patients) onto CM in diabetic patient published between 2000 and March 2020. Results Forty‐five reports of individual cases and eighteen case series articles were included. India accounted for the largest share of reports with 37.7% and 38.8% of individual cases and case series, respectively. Mortality ranged from 0% to 100% in the case series. The overall mortality in the individual cases was 46.3%, and 64.2% of deaths were reported in patients with ketoacidosis diabetes. Facial swelling (53.3%), headache (44.4%), loss of vision (35.5%) and ophthalmoplegia (35.5%) were the most frequently reported clinical symptoms. In all patients except 4 (91.1%), CM was treated surgically; however, in many cases (42%), despite the use of surgery, death occurred. Amphotericin B deoxycholate (AMB) and lipid‐based AMB (LAMB) were used as the first lines of treatment for all patients; however, posaconazole, echinocandins, hyperbaric oxygen therapy (HBOT) and deferasirox were used in combination for a number of patients. Posaconazole has been shown to have positive therapeutic effect; however, posaconazole, LAMB and HBOT are not commonly used in low‐income and health‐challenged countries. Conclusion Cerebral mucormycosis is a rapidly progressive infection in diabetic patients and carries immense morbidity despite early diagnosis and treatment. Low‐income countries have had the highest number of reports of the disease in recent years, indicating the need to control diabetes in these countries.

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Section: Discussionmentioning

confidence: 99%

Epidemiology, clinical features, diagnosis and treatment of cerebral mucormycosis in diabetic patients: A systematic review of case reports and case series

Chegini

Didehdar

Khoshbayan

et al. 2020

Mycoses

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“…CIFS is infrequently diagnosed and its indolent nature with progression over weeks or months can make diagnosis and treatment difficult [ 5 , 10 , 11 ]. The most frequent fungal species identified are the Aspergillus species, but Curvularia species have been found as well [ [7] , [8] , [9] , 11 ]. Usually, Curvularia species is associated with less severe diagnoses, including allergic rhinosinusitis, onychomycosis, and dermatitis [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…These infections are most frequently caused by Aspergillus species. Few cases in the literature have reported the cause due to Curvularia species [ [7] , [8] , [9] ]. In this case report, we describe an immunocompetent patient with intranasal cocaine and perfume inhalant use who developed invasive fungal sinusitis due to Curvularia species with disseminated disease.…”

Section: Introductionmentioning

confidence: 99%

Invasive fungal infection caused by curvularia species in a patient with intranasal drug use: A case report

Pham

Kulla

Johnson

2022

Medical Mycology Case Reports

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“…3,9 Table 1 is a summary of published case reports of invasive and allergic fungal rhinosinusitis caused by Curvularia. 5,6,[10][11][12][13][14][15][16][17][18][19][20] In the most recent published case of AFRS, a CT scan showed a heterogenous expansile mass in the right sphenoid sinus. 11 The patient underwent endoscopic sphenoidotomy and sinus cultures grew Curvularia.…”

Section: Discussionmentioning

confidence: 99%

Invasive Fungal Rhinosinusitis Caused by Curvularia in a Patient With Type 1 Diabetes Mellitus: A Case Report

Marinucci

Chahine

Bush

2020

Journal of Pharmacy Practice

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Invasive fungal rhinosinusitis (IFRS) is a serious illness requiring early diagnosis, surgical debridement, and administration of antifungals. We report a case of an acute IFRS caused by Curvularia in a patient with diabetes mellitus. An 18-year-old female presented to the emergency department with an acute onset of fever, headache, facial discomfort, and a blood glucose reading of 500 mg/dL. The patient was admitted for the management of hyperosmolar hyperglycemia. Her past medical history includes uncontrolled type 1 diabetes mellitus and a recent toothache. A computed tomography scan of the facial maxillary region revealed sinus disease with bony erosion. Empiric therapy with liposomal amphotericin B 400 mg i.v. every 24 hours, piperacillin/tazobactam 4.5 g i.v. every 6 hours and vancomycin 1 g i.v. every 12 hours was started. A functional endoscopic sinus surgery revealed invasive rhinosinusitis and cultures were positive for fungal elements. The patient was discharged on liposomal amphotericin B 400 mg i.v. daily and cefuroxime 500 mg orally twice daily. However, she was readmitted for the management of acute kidney injury and was discharged on itraconazole capsules 200 mg orally twice daily. Sinus cultures grew Curvularia and itraconazole was prescribed for 6 weeks, but the patient discontinued treatment after 3 weeks and had no signs or symptoms of rhinosinusitis when she was last seen in the clinic. The possibility of IFRS should be explored in patients with diabetes and signs and symptoms of rhinosinusitis.

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Breakthrough mucormycosis after voriconazole use in a case of invasive fungal rhinosinusitis due to <i>Curvularia lunata </i>

Cited by 11 publications

References 10 publications

Epidemiology, clinical features, diagnosis and treatment of cerebral mucormycosis in diabetic patients: A systematic review of case reports and case series

Epidemiology, clinical features, diagnosis and treatment of cerebral mucormycosis in diabetic patients: A systematic review of case reports and case series

Invasive fungal infection caused by curvularia species in a patient with intranasal drug use: A case report

Invasive Fungal Rhinosinusitis Caused by Curvularia in a Patient With Type 1 Diabetes Mellitus: A Case Report

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