Breakthroughs in AI and multi-omics for cancer drug discovery: A review

Fatima, Israr; Rehman, Abdur; Ding, Yanheng; wang, Peng; Meng, Yuxuan; Rehman, Hafeez Ur; Warraich, Dawood Ahmad; Wang, Zhibo; Feng, Lijun; Liao, Mingzhi

doi:10.1016/j.ejmech.2024.116925

European Journal of Medicinal Chemistry

2024

DOI: 10.1016/j.ejmech.2024.116925

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Breakthroughs in AI and multi-omics for cancer drug discovery: A review

Israr Fatima,

Abdur Rehman,

Yanheng Ding

et al.

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Biological Function Analysis of MicroRNAs and Proteins in the Cerebrospinal Fluid of Patients with Parkinson’s Disease

Hwang,

Kim,

George

et al. 2024

IJMS

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Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by alpha-synuclein aggregation into Lewy bodies in the neurons. Cerebrospinal fluid (CSF) is considered the most suited source for investigating PD pathogenesis and identifying biomarkers. While microRNA (miRNA) profiling can aid in the investigation of post-transcriptional regulation in neurodegenerative diseases, information on miRNAs in the CSF of patients with PD remains limited. This review combines miRNA analysis with proteomic profiling to explore the collective impact of CSF miRNAs on the neurodegenerative mechanisms in PD. We constructed separate networks for altered miRNAs and proteomes using a bioinformatics method. Altered miRNAs were poorly linked to biological functions owing to limited information; however, changes in protein expression were strongly associated with biological functions. Subsequently, the networks were integrated for further analysis. In silico prediction from the integrated network revealed relationships between miRNAs and proteins, highlighting increased reactive oxygen species generation, neuronal loss, and neurodegeneration and suppressed ATP synthesis, mitochondrial function, and neurotransmitter release in PD. The approach suggests the potential of miRNAs as biomarkers for critical mechanisms underlying PD. The combined strategy could enhance our understanding of the complex biochemical networks of miRNAs in PD and support the development of diagnostic and therapeutic strategies for precision medicine.

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Biological Function Analysis of MicroRNAs and Proteins in the Cerebrospinal Fluid of Patients with Parkinson’s Disease

Hwang,

Kim,

George

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

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Breakthroughs in AI and multi-omics for cancer drug discovery: A review

Cited by 1 publication

References 188 publications

Biological Function Analysis of MicroRNAs and Proteins in the Cerebrospinal Fluid of Patients with Parkinson’s Disease

Biological Function Analysis of MicroRNAs and Proteins in the Cerebrospinal Fluid of Patients with Parkinson’s Disease

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