Breast augmentation with an unknown substance

Ebrahim, Lamya; Morrison, David A.; Kop, Alan; Taylor, Donna

doi:10.1136/bcr-2014-204535

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…Since NMR is used widely by many fields (eg, solid-state physics, chemistry, biology, medical research, and medical diagnosis) to identify the previously unknown composition of a substance, this finding is likely to be highly reliable. 13 – 15 …”

Section: Discussionmentioning

confidence: 99%

Safety of Copolyamide Filler Injection for Breast Augmentation

Nomoto

Hirakawa

Ogawa

2021

Plastic and Reconstructive Surgery - Global Open

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Background: Although injections with copolyamide fillers (Aquafilling/Los Deline and Aqualift/Activegel) are currently used widely for breast augmentation, many complications have been reported. A recent position statement by a Korean aesthetic/reconstructive breast surgery society indicated these fillers are the same as polyacrylamide gel (PAAG), which is widely prohibited due to complications. To test this statement, this retrospective cohort study examined the clinical complications after breast augmentation with copolyamide fillers. Nuclear magnetic resonance (NMR) analysis of copolymer and PAAG fillers was also conducted. Methods: All consecutive patients with concerns about or sequelae from copolyamide fillers who visited our hospital in 2018–2020 were identified. The injected formulation, complications, and intraoperative findings were recorded. Copolyamide fillers were compared with PAAG and 2 PAAG fillers (Amazingel and Aquamid) by NMR. Results: Of the 29 patients (all women; average age, 42 years), 17 complained of breast deformity. Eight had puncture site infections and mammary gland inflammation. Five exhibited induration (single large/small lumps). In 4 cases, the filler had migrated outside of the breast, including to the back and vulva; these cases had severe symptoms. NMR showed that the copolyamide and PAAG fillers bore all of the characteristic peaks of PAAG. Conclusions: Our clinical/intraoperative and NMR findings showed, respectively, that copolyamide fillers cause the same complications as PAAG fillers and have the same composition. Thus, the risks of copolyamide fillers for breast augmentation are equivalent to those for PAAG fillers. It is strongly recommended not to use copolyamide fillers until their long-term safety is established.

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Section: Discussionmentioning

confidence: 99%

Safety of Copolyamide Filler Injection for Breast Augmentation

Nomoto

Hirakawa

Ogawa

2021

Plastic and Reconstructive Surgery - Global Open

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“…It was technically impossible in our case, because PAAG did not remain confined to a single collection ( 1 ). The gel usually forms multiple small locules occupying different layers of the breast, rather than being confined to a single collection, which can then be found even outside of the breast ( 3 5 6 ). Residual PAAG could be left behind, even after the surgery, as in our third case ( 3 5 6 ).…”

Section: Discussionmentioning

confidence: 99%

Radiologic Findings of Polyacrylamide Gel Mammoplasty and Its Complications: A Report of Four Case Series and Review of Literature

Kim

Hwang

Moon

et al. 2022

J Korean Soc Radiol

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Polyacrylamide gel (PAAG) has been used for augmentation mammoplasty in certain countries, such as China or Eastern European countries. However, owing to various complications, its use is currently banned in most countries. Nevertheless, because of the migratory stream of female from these countries, we also encounter patients with PAAG mammoplasty in Korea. Owing to the various imaging features of PAAG mammoplasty, it may interfere with the identification of malignancy or other pathologic conditions. Therefore, it is important to identify the imaging findings related to PAAG mammoplasty. However, there is limited literature on the radiologic findings of complications related to PAAG mammoplasty in Korea. Herein we report four cases of PAAG mammoplasty, the complications faced, and depict various radiologic features through multimodality imaging.

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“…Using a combination of fat suppression, water suppression, T 1 , T 2 and silicone weighting, one is able to distinguish between a wide variety of materials used to augment the breasts through direct injection, such as free silicone, paraffin, saline or autologous fat. 8 In addition, MRI is able to differentiate between reactive silicone granulomatous tissue and breast cancer, even in cases where the two entities are in close proximity. 9 This is an obvious advantage over ultrasound or CT scan.…”

Section: Discussionmentioning

confidence: 99%

Extensive migration of injected free liquid silicone for breast augmentation with related major complications

Hilton

Steinke²

2015

BJR|case reports

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Free liquid silicone breast injections have been used for off-label breast augmentation since the 1960s. Shortly after the invention of this technique, multiple adverse effects became apparent and the technique became illegal in most countries. The procedure continues to be undertaken owing to its decreased cost compared with silicone prostheses. Complications from free silicone injections lead to complex management issues and health risks. This case demonstrates severe silicone migration, the extent of which has not previously been documented. In addition, the migration caused a serious life-threatening complication with subsequent complex management issues.

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Breast augmentation with an unknown substance

Cited by 5 publications

References 6 publications

Safety of Copolyamide Filler Injection for Breast Augmentation

Safety of Copolyamide Filler Injection for Breast Augmentation

Radiologic Findings of Polyacrylamide Gel Mammoplasty and Its Complications: A Report of Four Case Series and Review of Literature

Extensive migration of injected free liquid silicone for breast augmentation with related major complications

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