Breast Cancer Detection Based on Incremental Biochemical and Physiological Properties of Breast Cancers

Chance, Britton; Nioka, Shoko; Zhang, Jun; Conant, Emily F.; Hwang, Emily; Briest, Susanne; Orel, Susan G.; Schnall, Mitchell D.; Czerniecki, Brian J.

doi:10.1016/j.acra.2005.04.016

Cited by 186 publications

(157 citation statements)

References 35 publications

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“…Intra-and interobserver agreement were good to excellent, indicating a reproducible method. Our results are in agreement with previously published studies using different techniques [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. Detection rates ranging from 0.04 to 1.00 were reported, irrespective of lesion classification (benign/malignant).…”

Section: Discussionsupporting

confidence: 83%

Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging

et al. 2009

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This paper presents an evaluation of a prototype diffuse optical tomography (DOT) system. Seventeen women with 18 breast lesions (10 invasive carcinomas, 2 fibroadenomas, and 6 benign cysts; diameters 13-54 mm) were evaluated with DOT and magnetic resonance imaging (MRI). A substantial fraction of the original 36 recruited patients could not be examined using this prototype due to technical problems. A region of interest (ROI) was drawn at the lesion position as derived from MRI and at the mirror image site in the contralateral healthy breast. ROIs were assessed quantitatively and qualitatively by two observers independently in two separate readings. Intra-and interobserver agreements were calculated using kappa statistics (k) and intraclass correlation coefficients (ICCs). Discriminatory values for presence of malignancy were determined by receiver operating characteristic (ROC) analyses. Intraobserver agreements were excellent (k 0.88 and 0.88; ICC 0.978 and 0.987), interobserver agreements were good to excellent (k 0.77-0.95; ICC 0.96-0.98). Discriminatory values for presence of malignancy were 0.92-0.93 and 0.97-0.99 for quantitative and qualitative ROC analysis, respectively. This DOT system has the potential to discriminate malignant from benign breast tissue in a reproducible qualitative and quantitative manner. Important technical improvements are required before this technique is ready for clinical application.

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Section: Discussionsupporting

confidence: 83%

Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging

et al. 2009

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“…The incorporation of anatomical information indicates that improved NIR image quality is achieved and will likely increase the potential for relevant physiological investigation. It appears increasingly probable that optical techniques will play important clinical roles when combined with other imaging systems, as recently demonstrated by Chance et al (6), demonstrating high sensitivity and specificity values when imaging breast cancer tumors. For example, optical signatures can be specific to molecular changes in tissue, as recently demonstrated with Raman spectroscopy (1, 3), and use of vascular permeability agents (33), lymphatic agents (34), and͞or molecular specific contrast agents (35) in this sort of tomography geometry will likely lead to useful diagnostic testing for specific disease processes.…”

Section: Discussionmentioning

confidence: 97%

“…Supplementing conventional imaging with functional information is an avenue to improve our understanding of tissues in vivo in both research and clinical settings. In a recent report, Chance et al (6) demonstrated that NIR tomography measurements could be used for extremely high sensitivity and specificity (96% and 93%, respectively) for tumors as small as 0.8 cm. It is generally thought that the only major limitation for NIR tomography lies in the area of low spatial resolution, and if it could be implemented in a manner that used the strengths of existing clinical modalities with the benefits of NIR contrast, the modality could become an accepted tool for clinical breast cancer imaging.…”

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confidence: 99%

“…The caveat of these methods is that they have short penetration and so are optimally suited for small tissue volume identification or surface imaging applications. In contrast, NIR light penetrates much further in tissue, yet has fewer and broader chemical specific absorption bands, to identify components of the tissue (4,5) and has reported data with extremely high sensitivity and specificity for cancer based on in vivo studies quantifying hemoglobin and oxygenation (6). The key spectral features are from water, hemoglobin, deoxyhemoglobin, lipids, and some potential for quantifying scattering, which is due to micrometer-sized structures such as collagen and membrane-bound organelles.…”

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confidence: 99%

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Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography

Brooksby

Pogue²,

Jiang³

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

226

211

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Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.hemoglobin ͉ magnetic resonance imaging ͉ water ͉ fat ͉ oxygen saturation

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“…Chance et al developed a NIR method capable of rapidly acquiring data from the breast with a handheld puck 48 . The CW device was used to measure tumor hemoglobin and hemoglobin desaturation compared to the mirror image site on the contralateral normal breast.…”

Section: Nir Spectroscopy and Imagingmentioning

confidence: 99%

Advances in Optical Spectroscopy and Imaging of Breast Lesions

Demos

Vogel

Gandjbakhche

2006

J Mammary Gland Biol Neoplasia

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Abstract:A review is presented of recent advances in optical imaging and spectroscopy and the use of light for addressing breast cancer issues. Spectroscopic techniques offer the means to characterize tissue components and obtain functional information in real time. Three-dimentional optical imaging of the breast using various illumination and signal collection schemes in combination with image reconstruction algorithms may provide a new tool for cancer detection and monitoring of treatment. 2 Chapter 1. BackgroundAccording to the National Institutes of Health, breast cancer is the most diagnosed nonskin cancer and the second leading cause of cancer death among women in the United States.Although the breast cancer diagnosis rate has increased, there has been a steady drop in the overall breast cancer death rate since the early 1990s. Depending on the size of the tumor and the involvement of the lymph nodes, survival rates can vary from 45-95%. The key problem with the breast is the variation in demographic size, texture, chemical composition, and age. X-ray mammography is the gold standard for breast cancer screening and detection. Mammography is most sensitive in women over 35-40 years of age because of their fatty breast composition 1 and less effective and sensitive in younger women because they have denser breasts 2 . For younger women, ultrasound is commonly used. Magnetic resonance imaging (MRI) can also play a significant role in the diagnosis and characterization of breast disease.According to the National Cancer Society, up to 10% of all breast cancers, roughly 20,000 cases per year in the U.S., are not discovered by X-ray mammography. Also, X-ray mammography uses ionizing radiation and requires uncomfortable breast compression. It also suffers from a significant number of false positives that often lead to unnecessary biopsy since biopsy is generally required to determine malignancy in most women with an abnormal Spatial and temporal contrasts in these properties may be uniquely useful for diagnosing disease.The objective of this work is to provide a comprehensive review of the progress of photonics methods to address breast cancer issues. This review is divided into three major focus areas: a) optical spectroscopy methods suitable for tissue evaluation in real time; b) noninvasive NIR spectroscopy for the acquisition of functional information; and c) optical imaging methods for functional tumor characterization. Chapter 2. Optical biopsy methodsThe term "optical biopsy" describes the use of optical spectroscopy to characterize tissue, and requires direct exposure of the tissue under examination to the light source. Consequently, its application in a clinical setting is best suited for intraoperative use to assist in exploring tissue in real time, or via thin fiberoptic needles that can reach the suspected location within the breast for a minimally invasive evaluation.The breast is complex; its multiple tissue components make it more difficult to classify using optical spectroscopy than other tissues (...

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Breast Cancer Detection Based on Incremental Biochemical and Physiological Properties of Breast Cancers

Cited by 186 publications

References 35 publications

Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging

Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging

Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography

Advances in Optical Spectroscopy and Imaging of Breast Lesions

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